Therapeutic drug monitoring of high-dose gentamicin in an elderly patient: a case report.

Objective: To report the pharmacokinetics of gentamicin using traditional multiple daily doses and a high-dose regimen in an elderly patient.

Clinical Presentation And Intervention: An 80-year-old male who presented with mild renal failure received two different gentamicin dosing regimens, 60 mg every 8 h for septicemia and a high dose of 400 mg with extended interval for suspected endocarditis. Based on population parameters of k(e) (0.