IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy.

Tumor cells are characterized by rapid proliferation. In order to provide purines for DNA and RNA synthesis, inosine 5'-monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo guanosine biosynthesis, is highly expressed in tumor cells. In this study we investigated whether IMPDH was involved in cancer immunoregulation.

Understanding the decomposition process of the PtAg(SPhCl) nanocluster at the atomic level.

We report the decomposition of the PtAg(SPhCl) nanocluster into a crown-like PtAg(SR) (SR = 2,4-SPhCl and 4-SPhBr) complex. UV-vis spectra and single crystal X-ray diffraction were used to track the structure-conversion process. Based on the total structure, the differences in ligand exchange rates at different sites and the effects on the stability were mapped out.

Transforming Silver Nanoclusters from Racemic to Homochiral via Seeded Crystallization.

Chirality has risen as an attractive topic in materials research in recent years, but the attainment of enantiopure materials remains a major challenge. Herein, we obtained homochiral nanoclusters by a recrystallization strategy, without any chiral factors (i.e.

Understanding a ligand's effects on intra-cluster and inter-cluster assembly.

Ligands play an essential role in cluster assembly; however, understanding this behavior at the atomic level is far off. In this work, CdAg(S-PhOMe)(PPh)@CdAg(S-PhOMe)Cl(PPh)@Ag(S-PhOMe)Cl (Abbrev. Cd12Ag32-1) and CdAg(S--CH) (Abbrev.