Publications by authors named "Keerthi B Jayasundera"
Article Synopsis
- Natural products, particularly isoprenoids, are used in various industries such as medicine, cosmetics, and biofuels, leading to a growing interest in microbial production methods.
- Advances in metabolic engineering through synthetic and systems biology have facilitated the modification of microorganisms to enhance isoprenoid yield by targeting biosynthetic pathways like the MEP and MVA.
- New combinations of the MVA pathway have shown improved carotenoid and lycopene production, making them promising for efficient industrial isoprenoid production while complying with safety regulations.
Engagement of the B cell receptor for antigen (BCR) leads to immune responses through a cascade of intracellular signaling events. Most studies to date have focused on the BCR and protein tyrosine phosphorylation. Because spleen tyrosine kinase, Syk, is an upstream kinase in multiple BCR-regulated signaling pathways, it also affects many downstream events that are modulated through the phosphorylation of proteins on serine and threonine residues.
View Article and Find Full Text PDFThe Syk protein-tyrosine kinase can have multiple effects on cancer cells, acting in some as a tumor suppressor by inhibiting motility and in others as a tumor promoter by enhancing survival. Phosphoproteomic analyses identified PKA as a Syk-specific substrate. Syk catalyzes the phosphorylation of the catalytic subunit of PKA (PKAc) both in vitro and in cells on Tyr-330.
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