Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell.

Background: Diabetes mellitus (DM) can cause severe complications, including diabetic foot ulcers (DFU). There is a significant gap in understanding the single-cell ecological atlas of DM and DFU tissues.

Methods: Single-cell RNA sequencing data were used to create a detailed single-cell ecological landscape of DM and DFU.

LiberRoad: Probing into the Journey of Chinese Classics Through Visual Analytics.

Books act as a crucial carrier of cultural dissemination in ancient times. This work involves joint efforts between visualization and humanities researchers, aiming at building a holistic view of the cultural exchange and integration between China and Japan brought about by the overseas circulation of Chinese classics. Book circulation data consist of uncertain spatiotemporal trajectories, with multiple dimensions, and movement across hierarchical spaces forms a compound network.

Methylation factors as biomarkers of fibromyalgia.

Background: Fibromyalgia (FM) is a common and intractable chronic musculoskeletal pain syndrome, but its exact underlying mechanisms are unknown. This study sought to identify biomarkers of FM and the underlying molecular mechanisms of the disease.

Methods: FM-related gene expression profiles (GSE67311) and methylation profiles (GSE85506) were obtained from the Gene Expression Omnibus database, and a differential expression analysis was performed to identify the methylation factors.

A review of the mechanism of succinylation in cancer.

Lysine succinylation is a novel, broad-spectrum, dynamic, non-enzymatic protein post-translational modification (PTM). Succinylation is essential for the regulation of protein function and control of various signaling and regulatory pathways. It is involved in several life activities, including glucose metabolism, amino acid metabolism, fatty acid metabolism, ketone body synthesis, and reactive oxygen species clearance, by regulating protease activity and gene expression.