Publications by authors named "Keenan Treat"
Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice.
Prog Neuropsychopharmacol Biol Psychiatry
August 2012
Article Synopsis
- Acetaminophen has been found to enhance social behavior in certain strains of mice (BTBR and 129S), while a cannabinoid agonist (WIN 55,212-2) did not promote sociability in the same way.
- The study showed that acetaminophen increased levels of endocannabinoids (anandamide and 2-arachidonyl glycerol) in the frontal cortex, suggesting that its sociability effects may be due to mechanisms beyond cannabinoid receptor interactions.
- Differences in receptor density and function among mouse strains were observed, indicating that acetaminophen's ability to promote sociability may be influenced more by serotonin receptor activity rather than cannabinoid receptor inhibition.