The QIBA Profile for Dynamic Susceptibility Contrast MRI Quantitative Imaging Biomarkers for Assessing Gliomas.

The dynamic susceptibility contrast (DSC) MRI measures of relative cerebral blood volume (rCBV) play a central role in monitoring therapeutic response and disease progression in patients with gliomas. Previous investigations have demonstrated promise of using rCBV in classifying tumor grade, elucidating tumor viability after therapy, and differentiating pseudoprogression and pseudoresponse. However, the quantification and reproducibility of rCBV measurements across patients, devices, and software remain a critical barrier to routine or clinical trial use of longitudinal DSC MRI in patients with gliomas.

All-cancer incidence and mortality in Pakistanis, Bangladeshis, and their descendants in England and Wales.

Background: This paper identifies differences in all-cancer incidence and mortality between Pakistani-born (PB), Bangladeshi-born (BB), their descendants, and the White British (WB) in England and Wales. Pakistanis and Bangladeshis are the most marginalised and disadvantaged groups in England and Wales yet, are found to have low cancer mortality and low all-cause mortality. Previous studies though have not looked at generational differences, applied individual-level data nor separated Pakistanis and Bangladeshis from each other and other Asian groups.

Paramagnetic salt and agarose recipes for phantoms with desired T1 and T2 values for low-field MRI.

Tissue-mimicking reference phantoms are indispensable for the development and optimization of magnetic resonance (MR) measurement sequences. Phantoms have greatest utility when they mimic the MR signals arising from tissue physiology; however, many of the properties underlying these signals, including tissue relaxation characteristics, can vary as a function of magnetic field strength. There has been renewed interest in magnetic resonance imaging (MRI) at field strengths less than 1 T, and phantoms developed for higher field strengths may not be physiologically relevant at these lower fields.

Intergenerational transmission of fertility in Great Britain: A parity-specific investigation using the 1970 British Cohort Study.

Studies in low-fertility settings have consistently found positive relationships between parents' and children's fertility timing and family sizes, and these persist after accounting for socio-demographic factors. We explore intergenerational transmission of fertility in Great Britain, where socio-economic inequalities are larger and could play a greater role in explaining intergenerational continuities than in other settings. Using the 1970 British Cohort Study, a long-running longitudinal data set, we estimate parity-specific discrete-time event-history models to investigate the role of mother's family size and age at first birth in birth transitions.

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation.

The search for new approaches in cancer therapy requires a mechanistic understanding of cancer vulnerabilities and anti-cancer drug mechanisms of action. Problematically, some effective therapeutics target cancer vulnerabilities that have poorly defined mechanisms of anti-cancer activity. One such drug is decitabine, a frontline therapeutic approved for the treatment of high-risk acute myeloid leukemia (AML).

Preconception and prenatal vitamin D associations with positive behavioral health in Black children.

Background: Low levels of vitamin D during pregnancy are associated with offspring behavioral problems but little is known about pre-pregnancy influences. Additionally, Black American individuals are underrepresented in studies, limiting translational impact. We tested independent and interactive effects of preconception and prenatal vitamin D in Black women in relation to positive behavioral and emotional outcomes in early childhood.

Color-map recommendation for MR relaxometry maps.

Purpose: To harmonize the use of color for MR relaxometry maps and therefore recommend the use of specific color-maps for representing , , and maps and their inverses.

Methods: Perceptually linearized color-maps were chosen to have similar color settings as those proposed by Griswold et al. in 2018.

Real-time automated quality control for quantitative MRI.

Objective: This work presents an automated quality control (QC) system within quantitative MRI (qMRI) workflows. By leveraging the ISMRM/NIST quantitative MRI system phantom, we establish an open-source pipeline for rapid, repeatable, and accurate validation and stability tracking of sequence quantification performance across diverse clinical settings.

Materials And Methods: A microservice-based QC system for automated vial segmentation from quantitative maps was developed and tested across various MRF acquisition and protocol designs, with reports generated and returned to the scanner in real time.

Short Report: Exploring the Effect of Prenatal Fatty Acid Supplementation on Wheeze and Asthma in Black American Children.

Background: Black American children are at higher risk for developing asthma than White children. Identifying potential scalable preventive interventions that can reduce the racial disparities in asthma prevalence and associated morbidity and mortality are needed. We leveraged data from an RCT of prenatal supplementation with docosahexaenoic acid (DHA) in Black American women, to explore whether prenatal fatty acid supplementation is associated with offspring wheeze and asthma.

Listening to the Perspectives of Black Women on Perinatal Health Disparities: Reversing the Tide and Improving Outcomes.

Introduction: Pregnancy-related health in the USA fares worse than similarly resourced countries and the gap continues to widen. This trend however is disproportionately experienced by women of color. We have come to understand that this is due to the systems and structures that perpetuate racism.

Etiology and antimicrobial susceptibility patterns of bacteria causing pneumonia among adult patients with signs and symptoms of lower respiratory tract infections during the COVID-19 pandemic in Mwanza, Tanzania: a cross-sectional study.

Background: Bacterial pneumonia is among the leading causes of morbidity and mortality worldwide. The extensive misuse and overuse of antibiotics observed during the Corona Virus Disease 2019 (COVID-19) pandemic may have changed the patterns of pathogens causing bacterial pneumonia and their antibiotic susceptibility profiles. This study was designed to establish the prevalence of culture-confirmed bacterial pneumonia and describe their antimicrobial susceptibility profile in adult patients who presented with signs and symptoms of lower respiratory tract infections (LRTIs) during the COVID-19 pandemic.

Color Maps: Facilitating the Clinical Impact of Quantitative MRI.

Presenting quantitative data using non-standardized color maps potentially results in unrecognized misinterpretation of data. Clinically meaningful color maps should intuitively and inclusively represent data without misleading interpretation. Uniformity of the color gradient for color maps is critically important.

Improving Time to Antibiotics in Patients With Long Bone Open Fractures Presenting to the Pediatric Emergency Department.

Objectives: To evaluate a new triage workflow aimed at improving time to intravenous antibiotics in open fractures to under less than 60 minutes of arrival to the Pediatric Emergency Department.

Design: A prospective, multidisciplinary, quality improvement project.

Setting: A tertiary care, Level 1 pediatric trauma hospital in New York.

Genome-wide association study of susceptibility to infection in cystic fibrosis.

Background: is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing (CF transmembrane conductance regulator) variations contribute ∼85% of the variation in chronic infection age in CF according to twin studies, but the susceptibility loci remain unknown. Our objective is to advance understanding of the genetic basis of host susceptibility to infection.

The appropriateness of empirical antibiotic therapy in the management of symptomatic urinary tract infection patients-a cross-sectional study in Nairobi County, Kenya.

Background: In low- and middle-income countries, symptomatic urinary tract infection (UTI) patients are often prescribed antibiotics without microbiological confirmation. UTIs caused by antibiotic-resistant bacteria are increasingly common, and this heightens the risk of empirical treatment failure. This study evaluates the appropriateness of empirical antibiotic therapy to UTI patients in Nairobi County, Kenya.

Increasing Gender Integration in U.S. Marine Corps Recruit Training: Policy Recommendations and Rationales From an Interdisciplinary Study.

Introduction: This article describes alternate models and policy recommendations created by an interdisciplinary team of researchers to increase gender integration at U.S. Marine Corps (USMC) recruit training.

Design Considerations for a Multidisciplinary Approach to Provide Policy Recommendations on Gender-Integrated Recruit Training in the Marine Corps.

Introduction: Recruit training is designed to transform civilians into physically fit military service members, who embody their service's core values and possess military discipline and skills. At the time this research began, the U.S.

Descriptive Epidemiology of Musculoskeletal Injuries During Marine Corps Recruit Training in Gender-Integrated and Male-Only Training Units.

Introduction: Musculoskeletal injuries (MSIs) occur frequently in military personnel. U.S.

Neuromuscular Strength and Power Predict Musculoskeletal Injury and Attrition During Marine Corps Recruit Training.

Introduction: Elevated rates of musculoskeletal injuries (MSIs) and attrition are documented in military recruit training. By identifying and addressing modifiable risk factors, the rate of successful training completion and military readiness can be enhanced. Despite their impact, the causes of MSIs and attrition among U.

Using the Capture-Recapture Technique to Estimate the Ascertainment-Corrected Incidence of Musculoskeletal Injuries During Marine Corps Recruit Training.

Introduction: Injury epidemiology research with military populations typically utilizes data obtained through medical chart review (MCR) or injury self-reports (ISRs). MCR data will not capture musculoskeletal injury (MSKI) data for which medical care was not sought, which is common during military recruit training. Injury self-report is affected by issues with recall, especially for MSKIs perceived as less severe.