Publications by authors named "Keely Nicole Wharton"
Article Synopsis
- Guinea pigs have been key in biomedical research and typically require sedation for experiments, with the ketamine-xylazine (KX) combination being the standard sedative for years.
- A study explored substituting xylazine with midazolam and examined its combination with ketamine and alfaxalone, finding that KX offered the fastest and longest sedation, while midazolam had shorter duration and increased heart rate effects.
- Despite KX being the most effective, midazolam is not a suitable alternative due to its potential for adverse effects, whereas the midazolam-alfaxalone combination showed a safer profile without significant side effects.
Guinea pigs are often used in translational research, but providing them with safe and effective anesthesia is a challenge. Common methods like inhalant anesthesia and injectable ketamine/xylazine induce surgical anesthesia but can negatively affect cardiovascular, respiratory, and thermoregulatory systems and complicate the interpretation of research outcomes. Several alternative anesthetic regimens have been investigated, but none have consistently achieved a surgical plane of anesthesia.
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