Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome.

Objective: To compare the effect of clomiphene citrate (CC) and letrozole on endometrial receptivity in women with polycystic ovary syndrome (PCOS).

Design: A randomized controlled trial.

Setting: University teaching hospital.

Absence of neurotoxicity with medicinal grade terbutaline in the rat model.

To evaluate neurological effects of terbutaline, rats were injected with saline, terbutaline (Sigma or American Pharmaceutical Partners (APP™)) at 0.5 mg/kg-d or 10 mg/kg-d between postnatal days (PND) 2-5 or 11-14. Brains collected 24 h after last injection were used to determine corpus-callosum thickness, Purkinje cell and neuronal number in the cerebellum.