Publications by authors named "Kedi Zheng"
Article Synopsis
- The study aimed to create an easy-to-use nomogram for predicting interstitial lung disease (ILD) in patients with idiopathic inflammatory myositis (IIM) based on a large retrospective analysis of 205 patients from Shantou Central Hospital.
- Using LASSO regression, researchers identified four risk factors (age, respiratory symptoms, MDA-5 antibodies, and anti-ARS antibodies) and found that including KL-6 levels and LUS B-lines significantly improved the model's predictive accuracy.
- The final model showed strong predictive performance with an ROC AUC of up to 0.951, and a web version was created to enhance accessibility for clinicians.
Article Synopsis
- The study aimed to create a machine learning algorithm to predict the risk of malignancy in patients with idiopathic inflammatory myopathies (IIM), as early detection can improve prognosis.
- Researchers reviewed medical records of 168 IIM patients and identified three significant risk factors for malignancy: age, ALT levels under 80U/L, and anti-TIF1-γ, while ILD was a protective factor.
- Logistic regression was found to be the most effective model for prediction, achieving an AUC of 0.900 in the training set, and a web-based tool was created to facilitate use of this prediction model in clinical settings.
Objective: To investigate the role of serum B-cell activating factor (BAFF) and lung ultrasound (LUS) B-lines in connective tissue disease related interstitial lung disease (CTD-ILD), and their association with different ILD patterns on high resolution computed tomography (HRCT) of chest.
Methods: We measured the levels of BAFF and KL-6 by ELISA in the sera of 63 CTD-ILD patients [26 with fibrotic ILD (F-ILD), 37 with non-fibrotic ILD (NF-ILD)], 30 CTD patients without ILD, and 26 healthy controls. All patients underwent chest HRCT and LUS examination.
Introduction: To describe the clinical and laboratory features of systemic lupus erythematosus (SLE) enteritis and to establish a predictive model of risk and severity of lupus enteritis (LE).
Methods: Records of patients with SLE complaining about acute digestive symptoms were reviewed. The predictive nomogram for the diagnosis of LE was constructed by using R.
Screening and follow-up of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) is a challenge in clinical practice. In fact, the majority of RA-ILD patients are asymptomatic and optimal tools for early screening and regular follow-up are lacking. Furthermore, some patients may remain oligosymptomatic despite significant radiological abnormalities.
View Article and Find Full Text PDFObjective: Idiopathic inflammatory myositis-associated interstitial lung disease (IIM-ILD) significantly increases morbidity and mortality. Lung ultrasound B-lines and Krebs von den Lungen-6 (KL-6) are identified as new sonographic and serum markers of ILD, respectively. The aim of our work was to assess the role of B-lines and KL-6 as markers of the severity of IIM-ILD.
View Article and Find Full Text PDFAcute fibrinous and organizing pneumonia (AFOP) is a new histopathological pattern of acute lung injury first described by Beasley et al. in 2002. Hallmarks of pathological findings are characterized by the presence of intra-alveolar fibrin in the form of fibrin "balls" within the alveolar spaces and organizing pneumonia with a patchy distribution.
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