Publications by authors named "Kedarnath Dash"
Cowden syndrome (CS) is an infrequent autosomal dominant multisystem genodermatosis, generally involving the skin, oral mucosa, thyroid, breast and gastrointestinal tract. It is characterized by a late onset in the 2(nd) or 3(rd) decade of life, an extraordinary potential for malignant transformation, especially of breast and thyroid, and an identifiable germline mutation. In 80% cases, the human tumor suppressor gene, phosphatase and tensin homolog (PTEN) is mutated; mutations involving KILLIN, SDH B/D, PIK3CA and AKT1 genes account for the rest of the cases.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates various skin changes in newborns during their first five days, linking these changes to maternal and neonatal factors like delivery method and newborn characteristics.
- - A descriptive cross-sectional analysis of 300 neonates revealed common skin conditions such as superficial cutaneous desquamation and Mongolian spots, which showed significant statistical relationships with certain maternal and neonatal factors.
- - The findings highlight the need for further research in neonatal dermatology to deepen understanding, as some skin conditions were significantly correlated with factors like gestational age and maternal illnesses.
Dyshidrosiform pemphigoid with Parkinsonism in a nonagenarian Maharashtrian female.
Indian Dermatol Online J
October 2014
Dyshidrosiform pemphigoid is a rare variant of bullous pemphigoid localized to the hands and feet whose characteristic subepidermal blisters develop as a result of binding of the IgG autoantibodies to intracellular plaque and extracellular face of the hemidesmosome recognizing a 230-kDa plakin molecule (BP230, BPAg1or BPAg1e) and a 180-kDa transmembrane protein. Neurodegenerative processes (viz., stroke, dementia, Parkinsonism, epilepsy, etc) uncover BPAg1-n, an alternatively spliced form of BPAg1-e that stabilizes the cytoskeleton of sensory neurons, generating autoantibodies that may subsequently lead to BP by cross-reacting with BPAg1-e.
View Article and Find Full Text PDFA 20-year-old male presented with multiple eruptions on his right leg since birth; these bled and were painful on trivial trauma. Examination revealed dark brown, hyperkeratotic, indurated, verrucous linear plaques with irregular borders. Histopathological evidence of hyperkeratosis, acanthosis, and extensive vascular proliferation in papillary dermis confirmed clinical suspicion of angiokeratoma circumscriptum (AKC).
View Article and Find Full Text PDFBackground: Chronic renal failure (CRF) is associated with a variety of cutaneous manifestations as a result of underlying etiology as well as the various treatment modalities.
Aim: To evaluate the prevalence of various dermatoses in patients with CRF on hemodialysis and to study the effect of hemodialysis on the intensity of pruritus.
Materials And Methods: A total of 35 patients of CRF on hemodialysis having at least one cutaneous manifestation were included in the study.