Amperometric Highly Sensitive Phosphate Ion Sensor Based on the Electrochemically Modified Ni Electrode.

We present a study of high-performance electrochemical phosphate sensors, which are exquisitely designed and easy to operate. We innovatively utilized the insolubility of nickel phosphate and developed a new type of sensor through electrochemical methods. The experiment first used cyclic voltammetry to determine -0.

The Role of Histone H2B Acetylation Modification in Aluminum-Induced Cognitive Dysfunction.

Aluminum (Al) is a low toxic trace element that can accumulate in the nervous system and induce cognitive disorders characterized by reduced learning and memory ability. Neuroepigenetic effects are structural changes in cellular function by the brain in response to environmental stimuli by altering the expression of specific genes and repressing normal cellular transcription, leading to abnormalities in a variety of biological processes within the nervous system and affecting neurobehavioral responses. One of the most important mechanisms of epigenetic control on chromatin shape is histone modification.

Praeruptorin B inhibits osteoclastogenesis by targeting GSTP1 and impacting on the S-glutathionylation of IKKβ.

Osteoporosis a common disease in postmenopausal women which contains significant impact on the living quality of women. With the aging of the population, the number of patients suffer from osteoporosis has shown a significant increase. Given the limitations of clinical drugs for the treatment of osteoporosis, natural extracts with small side effects have a great application prospect in the treatment of osteoporosis.

A Comparison of Endoscopic Closure and Laparoscopic Repair for Gastric Wall Defection.

Objective: To compare the effectiveness and safety of endoscopic closure and laparoscopic repair for gastric wall defection.

Method: The clinical data of 120 patients with submucosal tumours enrolled at our hospital between January 2014 and December 2019 were retrospectively analysed. Patients were divided into two groups according to the surgery they underwent: an endoscopic closure group ( = 60) and a laparoscopic repair group ( = 60).

Potentiometric Phosphate Ion Sensor Based on Electrochemical Modified Tungsten Electrode.

Determination of phosphate ions in aqueous solutions attracts a great deal of interest in the areas of environment, medicine, and agriculture. As phosphoric acid is a poly basic acid, the different forms of existence at different pH result in direct determination facing a big challenge. Herein, we reported a potentiometric phosphate ion sensor based on a surface-modified tungsten electrode.

Automatic Management of Nutrient Solution for Hydroponics-Construction of Multi-ion Stat.

In order to improve plant factories, an appropriate control system on fertilization is urgently required. An automatic management system to control nutrient concentration was constructed using a programmable logic controller (PLC) and ion selective electrodes (ISEs) of nitrate, phosphate, and potassium ion. The concentration of nutrient components in a culture solution was monitored using these ISEs.

Dl-3n-butylphthalide improves traumatic brain injury recovery via inhibiting autophagy-induced blood-brain barrier disruption and cell apoptosis.

Blood-brain barrier (BBB) disruption and neuronal apoptosis are important pathophysiological processes after traumatic brain injury (TBI). In clinical stroke, Dl-3n-butylphthalide (Dl-NBP) has a neuroprotective effect with anti-inflammatory, anti-oxidative, anti-apoptotic and mitochondrion-protective functions. However, the effect and molecular mechanism of Dl-NBP for TBI need to be further investigated.

Berberine attenuated the cytotoxicity induced by t-BHP via inhibiting oxidative stress and mitochondria dysfunction in PC-12 cells.

Neurodegenerative diseases all share several common features such as involvement of oxidative damage and mitochondrial dysfunction in pathogenesis. Oxidative stress induced by overproduction of mitochondrial reactive oxygen species (ROS) or impairment of the antioxidant deficiency results in mitochondrial dysfunction and initiation of the cell death cascade. Berberine (BBR), a traditional Chinese medicine, has been reported to exert anti-oxidative stress and anti-apoptosis effect in CNS diseases.

Fabrication of a Phosphate Ion Selective Electrode Based on Modified Molybdenum Metal.

A phosphate ion-selective electrode using molybdenum metal was constructed. The modified molybdenum electrode responded to HPO in the presence of molybdenum dioxide and molybdophosphate (PMoO) on the surface. The electrode exhibited a linear response to HPO in the concentration range between 1.

Construction of an Automatic Nutrient Solution Management System for Hydroponics-Adjustment of the K-Concentration and Volume of Water.

An automatic management system for nutrient solutions was constructed using a programmable logic controller (PLC) and a K-ion selective electrode (K-ISE). The concentration of K was monitored by the K-ISE. When the concentration of K fell to the threshold limit, an appropriate amount of a concentrated K solution was added to the hydroponic solution.

Isoliquiritigenin protects against blood‑brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury.

Traumatic brain injury (TBI) caused by an external mechanical force acting on the brain is a serious neurological condition. Inflammation plays an important role in prolonging secondary tissue injury after TBI, leading to neuronal cell death and dysfunction. Isoliquiritigenin (ILG) is a flavonoid monomer with anti-inflammatory characteristic.

Hydrogen Sulfide Ameliorates Blood-Spinal Cord Barrier Disruption and Improves Functional Recovery by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy.

Spinal cord injury (SCI) induces the disruption of blood-spinal cord barrier (BSCB), which elicits neurological deficits by triggering secondary injuries. Hydrogen sulfide (HS) is a gaseous mediator that has been reported to have neuroprotective effect in the central nervous system. However, the relationship between HS and BSCB disruption during SCI remains unknown.

NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K/Akt/mTOR signalling pathway to improve functional recovery after traumatic brain injury.

Traumatic brain injury (TBI) is one of the most serious public health problems in the world. TBI causes neurological deficits by triggering secondary injuries. Hydrogen sulfide (HS), a gaseous mediator, has been reported to exert neuroprotective effects in central nervous system diseases, such as TBI.

Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats.

Hypoxic-ischemic and inflammatory (HII) induces the disruption of blood-brain barrier (BBB) which leads to inflammatory responses and neuronal cell death, resulting in brain secondary damage. Previous studies showed that melatonin produced potent neuroprotective effects in neonatal hypoxic-ischaemic models. However, the relationship between BBB disruption and melatonin in HII was still unclear.

Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway.

Endoplasmic reticulum (ER) stress-induced apoptosis plays an important role in a range of neurological disorders, such as neurodegenerative diseases, spinal cord injury, and diabetic neuropathy. Valproate (VPA), a typical antiepileptic drug, is commonly used in the treatment of bipolar disorder and epilepsy. Recently, VPA has been reported to exert neurotrophic effects and promote neurite outgrowth, but its molecular mechanism is still unclear.

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia.

Neonatal hypoxic-ischemic brain injury is a devastating disease with limited treatment options. Preventive treatment with resveratrol has indicated to be well tolerated and has lower toxicity in both experimental models and human patients. However, whether resveratrol administration post-hypoxic-ischemic protects against neonatal hypoxic-ischemic injury is not known.

Effect of route of preoperative biopsy on endoscopic submucosal dissection for patients with early gastric cancer.

Objective: To observe and compare the effects of multi-patch biopsy under conventional white light imaging endoscopy (C-WLI) and precise targeted biopsy under magnifying narrow-band imaging endoscopy (M-NBI) on the endoscopic submucosal dissection (ESD) of early gastric cancers and intraepithelial neoplasias.

Methods: According to the way of selecting biopsy specimens, patients were divided into C-WLI and M-NBI groups, 20 cases. The ESD operations of the 2 groups were compared quantitively.

Learning nonlinear multiregression networks based on evolutionary computation.

This paper describes a novel knowledge discovery and data mining framework dealing with nonlinear interactions among domain attributes. Our network-based model provides an effective and efficient reasoning procedure to perform prediction and decision making. Unlike many existing paradigms based on linear models, the attribute relationship in our framework is represented by nonlinear nonnegative multiregressions based on the Choquet integral.