Publications by authors named "Kebede A"

Background: Birth-related mortality is significantly increased by home births without skilled medical assistance during delivery, presenting a major risk to the public's health. The objective of this study is to predict home delivery and identify the determinants using machine learning algorithm in sub-Saharan African.

Methods: This study used design science approaches.

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The twin reversed arterial perfusion (TRAP) sequence is a rare complication associated with monochorionic twins. It is characterized by blood flow from the umbilical artery of the normal (pump) twin to the umbilical artery of the abnormal (acardiac) twin via artery-to-artery anastomosis. This condition is associated with 100% mortality in the acardiac twin and a high rate of perinatal morbidity and mortality in the pump twin, primarily due to intrauterine hypoxic injury, heart failure, and prematurity.

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Background: In light of the increasing diversity within school populations globally, a pressing need arises for nations to prioritise the enhancement of teachers' competencies in implementing inclusive education, recognising the central role teacher education programmes play in addressing this imperative. Teacher education programmes centred on inclusion not only respond to this global priority but also wield influence on teachers' attitudes, self-efficacy and stress levels when engaging with diverse learners.

Objectives: The study presents an analysis of the effectiveness of a teacher education programme in Ethiopia in developing teachers' competencies for inclusion.

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In this research, the photophysical properties of metformin hydrochloride (MF-HCl) were studied using spectroscopic and molecular docking techniques. The interaction between metformin hydrochloride and caffeine is essential for understanding the pharmacokinetics of metformin, particularly in populations with high caffeine consumption. Metformin is a first-line medication for managing type 2 diabetes, while caffeine is a widely consumed dietary stimulant.

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Bovine viral diarrhea (BVD) is a highly infectious disease affecting cattle, leading to significant economic losses in many countries engaged in cattle production. From February 2022 to October 2022, a study was conducted to determine the seroprevalence and associated risk factors of Bovine Viral Diarrhea Virus (BVDV) in the Sebeta subcity area of Sheger city, Ethiopia. The study utilized a semi-structured questionnaire to gather information on herd management practices from dairy farm owners.

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Background: Gender-Based Violence (GBV) is one of the major problems that women and girls encountered during the conflict between the Ethiopian federal government and the Tigray People's Liberation Front (TPLF). However, there is a gap in evidence regarding gender-based violence resulting from the ongoing conflict in these areas. Therefore, this study assessed the prevalence of GBV and its contributing factors in the conflict-affected northeastern Amhara region of Ethiopia.

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Background: Prostate cancer is a leading cause of cancer-related mortality among men, second only to lung cancer. Prostate magnetic resonance imaging (MRI) utilizing the Prostate Imaging and Reporting Data System (PI-RADS) v2.1 scoring system effectively stratifies patients by risk and correlates significantly with histopathological outcomes.

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Background: Perianal fistula refers to an abnormal connection between the anal canal and the perianal skin or perineum. Magnetic Resonance Imaging (MRI) plays a crucial role in accurately characterizing perianal fistulas, which informs surgical strategies and helps minimize recurrence.

Methods: This cross-sectional study was conducted at a single diagnostic imaging center in Addis Ababa, utilizing retrospectively collected data from May 2023 to June 2024.

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Background: Individuals can learn their HIV status through voluntary HIV counseling and testing (VCT), which also serves as a crucial access point for prevention, treatment, care, and support programs. VCT has grown in significance as a component of HIV prevention and care in Ethiopia because of its viability and convenience for the wider community, as well as its ability to provide access to care, treatment, and support for those in need. However, studies on this topic are limited, particularly because the fidelity of Ethiopia's VCT program has not been evaluated or measured.

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Article Synopsis
  • Comprehensive next generation sequencing (NGS) is being explored for its potential in diagnosing and treating pediatric hematologic malignancies, but its effectiveness is not yet fully established.
  • The study involved comprehensive genomic profiling of 28 patients at a pediatric care center, utilizing exome and RNA sequencing to analyze various genetic changes.
  • Of the 18 patients who underwent both germline and somatic sequencing, 83% had cancer-related findings, with targeted therapies beneficial for some, leading to long-term remission in a few cases.
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Background: Family planning (FP) is part of Ethiopia's essential health service package. However, integrating FP into other health care services is a relatively new concept. Integrated service can minimize missed opportunities and allow health workers to provide FP services and Reproductive, Maternal, Newborn, Child, Adolescent, and Nutrition (RMNCAH-N) services simultaneously.

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Background: Antimicrobial resistance (AMR) poses a significant global threat, particularly in low- and middle-income countries, such as Ethiopia, where surveillance is limited. This study aimed to predict and characterize the AMR profiles of diarrheagenic (DEC) and nontyphoidal (NTS) strains isolated from human, animal, food, and environmental samples using whole genome sequencing.

Methods: A total of 57 NTS and 50 DEC isolates were sequenced on an Illumina NextSeq 550.

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Campylobacter is a major zoonotic foodborne pathogen that poses a significant public health threat, particularly among children and immunocompromised individuals. However, data on the occurrence and sources of Campylobacter infection remain scarce in Ethiopia. This study assessed the occurrence, diversity, and relationships between Campylobacter from diarrheic children and potential exposure sources using whole-genome sequencing.

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Background: The spread of multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge to TB control efforts. This study evaluated the treatment outcomes and associated factors among patients receiving treatment for MDR-TB in southern Ethiopia.

Methods: A retrospective follow-up study covering ten years, from 2014 to 2023, analyzed the records of confirmed cases of pulmonary TB admitted to Yirgalem General Hospital, an MDR-TB treatment initiation center in the Sidama Region.

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Introduction: Although wastewater-based epidemiology (WBE) successfully functioned as a tool for monitoring the coronavirus disease 2019 (COVID-19) pandemic globally, relatively little is known about its utility in low-income countries. This study aimed to quantify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater, estimate the number of infected individuals in the catchment areas, and correlate the results with the clinically reported COVID-19 cases in Addis Ababa, Ethiopia.

Methods: A total of 323 influent and 33 effluent wastewater samples were collected from three Wastewater Treatment Plants (WWTPs) using a 24-h composite Moore swab sampling method from February to November 2023.

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Background: Accurate reference intervals generated from an apparently healthy population and stratified by crucial variables such as age and gender are required to guarantee appropriate interpretation of test results. Since there were no local reference intervals in the study area, the present study aimed to establish reference intervals on serum lipid profiles and electrolytes for children and adolescents in Addis Ababa.

Methods: This community-based cross-sectional study was conducted from April to October 2019.

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Article Synopsis
  • Opportunistic infections (OIs) are a serious risk for HIV-infected children in Ethiopia, even with advancements in antiretroviral therapy (ART), and this study aimed to assess their occurrence and predictive factors.
  • The research analyzed data from 409 HIV-infected children under 15 years, finding that 29.8% developed at least one OI, especially pulmonary tuberculosis, with an incidence rate of 12.8 per 100 person-years.
  • Significant predictors for OIs included not disclosing HIV status, age (particularly 10-14 years), lack of mother-to-child transmission prevention history, and low hemoglobin levels, highlighting the need for targeted interventions.
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  • Sweet syndrome is a rare inflammatory skin disorder that presents with painful, swollen, and red skin lesions, and has various types, including a unique giant cellulitis-like variant, as observed in a 60-year-old Ethiopian male patient.
  • The patient exhibited severe skin symptoms and fever, but did not initially respond to antibiotics; further investigation through a skin biopsy confirmed the diagnosis of the giant cellulitis-like variant of Sweet syndrome.
  • The case emphasizes the need for healthcare providers to consider Sweet syndrome in their diagnoses, especially when unusual skin lesions do not respond to typical treatments, enhancing awareness for better diagnostic practices.
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Foodborne pathogens (FBPs) are transmitted principally through the consumption of contaminated food or drinking water and pose a remarkable public health risk, particularly in low-income countries. A cross-sectional study was conducted between November 2021 and January 2023 to estimate the prevalence, co-occurrence, and monthly patterns of FBPs in the physical exposures of children with diarrhea in Harar town and Kersa district, Ethiopia. Animal, food, and environmental samples were collected from direct or indirect contact sites of children with diarrhea.

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  • Arginine vasopressin deficiency leads to central diabetes insipidus, characterized by excessive urination and varying degrees of pituitary dysfunction related to a condition known as partial empty sella.
  • A case study features an 18-year-old Ethiopian woman with symptoms like headaches, increased thirst and urination, and absence of menstruation, diagnosed with diabetes insipidus and a partially empty sella.
  • The conclusion emphasizes the rarity of diabetes insipidus due to a partially empty sella and suggests that this condition should be considered when patients exhibit headache and pituitary dysfunction symptoms.
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Article Synopsis
  • * A survey conducted in African Union Member States revealed significant variability in testing capacity and diagnostic technologies across countries, with many nations struggling to address challenges related to priority diseases like dengue and Crimean-Congo haemorrhagic fever.
  • * Investments in diagnostic capacity for diseases like COVID-19, polio, and measles showed better outcomes, but the lack of multiplex testing and overall limited laboratory capabilities raised concerns about preparedness for future outbreaks.
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Introduction: Road traffic accident is the most common cause of death in adults worldwide. Road traffic accident-related deaths increased from time to time in low- and middle-income countries including Ethiopia; however, there is limited evidence about Survival status and its predictors among adult victims of road traffic accidents admitted to Hospitals in Ethiopia specifically in the study area. Thus, this study aimed to assess Survival status and its predictors among adult victims of road traffic accident admitted to Hospitals.

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The textile industry uses a lot of adhesives to join materials together, and many of these adhesives use petroleum-based ingredients that are harmful to the environment. To replace petroleum-based adhesives with a more environmentally friendly option for the textile industry, this study set out to create and evaluate a hot-melt adhesive derived from cassava starch. By adding kaolin clay as a filler and tannin as a tackifier in different ratios of starch, the created adhesive was enhanced.

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Introduction: This scoping review investigates the extent and nature of existing evidence on the role of non-governmental organizations (NGOs) and related mechanisms of engagement and challenges in issues of caring for older persons through digital technologies. We map research and practice gaps, contributing factors and best practices in NGOs. The rising use of digital technology in health care and the role that NGOs have in supporting older people in this context is relevant to nurses and service development leaders, particularly in the context of a rapidly changing care in the 21 century.

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Over the past two decades (2000-2020), Ethiopia achieved significant reductions in maternal and neonatal mortality, with a 72% and 44%, respectively. However, low maternal health service utilization and dropout from the maternal continuum of care remain major health system challenges. This study aimed to investigate individual and community-level determinants of dropout from the maternal continuum of care.

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