Publications by authors named "Keaton J Solo"
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that males, but not females, have decreased body fat, moderate hypoglycemia upon fasting, and perturbed glucose handling during exercise compared to wild type controls. Conversion of injected lactate, pyruvate, and glycerol boluses into glucose via gluconeogenesis was impaired, but only in males.
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- Dicarboxylic fatty acids like dodecanedioic acid (DC12) are produced in the liver and kidney, but their dietary effects are unexplored.
- In a study, mice were fed DC12 at 20% of their daily caloric intake for nine weeks, resulting in increased metabolic rate, reduced body fat, and improved glucose tolerance.
- The research shows that DC12 was metabolized in various tissues and may be beneficial for addressing obesity and metabolic disorders.