Publications by authors named "Kean S"

School-based immunization programs are crucial for equitable vaccine coverage, yet their success depends on parental consent processes. This study investigates patterns of vaccine decision-making within Australia's school-based immunization program, specifically focusing on human papillomavirus (HPV) and diphtheria-tetanus-pertussis (dTpa) vaccines offered free to adolescents aged 12-13. This qualitative study was conducted in the South Eastern Sydney Local Health District (2022-2023).

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: Given the discrepancies in immunisation coverage, the goal of this study was to explore the barriers and facilitators to effective communication across the school-based vaccination program in South Eastern Sydney schools. : A qualitative study was undertaken with purposively selected immunisation staff, school coordinators, and parents of Year 7 students who had not received two vaccinations (dTpa and HPV) at school. A focus group with immunisation staff and interviews with school coordinators explored the barriers and facilitators to vaccination uptake, including communication across stakeholders.

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Objective: Hysterectomy has been the historical gold standard final step in the treatment algorithm of adenocarcinoma in situ (AIS) recommended by most North American colposcopy guidelines. AIS disproportionately affects young childbearing age women, therefore a fertility sparing treatment option is desirable. Our study examines the impact of conservative treatment of AIS with conization followed by serial surveillance.

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Article Synopsis
  • Cardiac surgery for coronary artery disease decreased significantly during the first COVID-19 pandemic wave, leading many patients to receive percutaneous coronary intervention (PCI) instead of the usual coronary artery bypass grafting (CABG).
  • A study tracked 215 patients who underwent PCI, gathering 12-month outcomes like death, heart attacks, and other complications to evaluate the procedure's effectiveness.
  • Results showed that after a year, PCI had acceptable outcomes with low rates of major adverse events, suggesting the need for further research comparing PCI to CABG in similar patient populations.
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Despite many countries having policies and systems for universal healthcare coverage, health disparity persists, with significant variations in disease prevalence and life expectancy between different groups of people. This focused ethnography explored the post-stroke recovery of Indigenous and non-Indigenous populations in three geographical areas in Taiwan. Forty-eight observations and 24 interviews were carried out with 12 dyads of stroke survivors and family caregivers, revealing their varied experiences of healthcare.

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Aim: To explore the experiences pertaining to long-term care services from the perspectives of dyads of stroke survivors and their family caregivers in indigenous and non-indigenous communities.

Background: Stroke occurrence is a life-changing event associated with quality of life for stroke survivors and their families, especially those who provide primary support. Indigenous people are more likely to experience a stroke at a younger age and have a higher likelihood of hospitalisation and death due to health disparities.

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Background: The contribution of the statistician to the design and analysis of a clinical trial is acknowledged as essential. Ability to reconstruct the statistical contribution to a trial requires rigorous and transparent documentation as evidenced by the reproducibility of results. The process of validating statistical programmes is a key requirement.

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Aim: The aim of this article is to describe and compare the nurse educator competences in four European countries using three different evaluators: nurse educators (n = 329), heads of a nursing subject (n = 60) and student nurses (n = 1058).

Design: The study was conducted as a comparative cross-sectional survey in Finland, Malta, Slovakia and Spain between May 2021 and February 2022.

Methods: The data were collected with an online survey.

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Researchers share award for developing quantum dots, which fluoresce in vivid colors determined by their size.

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The purpose of this paper is to provide evidence-based guidance on the management of a positive human papilloma virus (HPV) test and to provide guidance around screening and HPV testing for specific patient populations. The guideline was developed by a working group in collaboration with the Gynecologic Oncology Society of Canada (GOC), Society of Colposcopists of Canada (SCC), and the Canadian Partnership Against Cancer. The literature informing these guidelines was obtained through a systematic review of relevant literature by a multi-step search process led by an information specialist.

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Individuals that have gynecologic reproductive organs with pathogenic variants in BRCA1 or BRCA2 ("BRCA-positive") have an increased risk of developing high-grade serous ovarian cancer (HGSOC). The majority of HGSOC develops in the fallopian tubes and later spreads to the ovaries and peritoneal cavity. Therefore, risk-reducing salpingo-oophorectomy (RRSO) is recommended for those who are BRCA-positive to preventatively remove their ovaries and fallopian tubes.

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  • - Endometrial carcinoma (EC) has four molecular subtypes, with the no specific molecular profile (NSMP) subtype being the most common, found in about 50% of cases. Although it generally has a favorable prognosis, it includes a wide range of tumor characteristics.
  • - This study analyzed 1,110 NSMP ECs to identify factors that could predict outcomes, focusing on clinicopathologic features, immunohistochemical markers, and genetic information to categorize tumors as low-risk or high-risk.
  • - Key findings revealed that low-risk NSMP tumors (grade 1-2, ER-positive) had a 5-year disease-specific death rate of only 1.6%, in contrast to high-risk NS
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  • Recent research indicates that the type of molecular subtype in endometrial cancer (EC) can help predict clinical outcomes and guide treatment decisions.
  • In a study involving 2,472 EC patients, adjuvant chemotherapy showed significant benefits for patients with p53abn subtype but did not provide additional benefits for those with MMRd subtype.
  • The findings suggest that while adjuvant chemotherapy improves survival in p53abn EC patients, it may not enhance outcomes for MMRd patients, highlighting the need for further research tailored to specific molecular subtypes.
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Objectives: The study aimed at describing the field of research in continuing professional development for nurse educators and the continuous education and development needs of nurse educators by asking: What research has been done in the field of continuing professional development of nurse educators? What are the continuing education and development needs and requirements reported for and by nurse educators?

Design: An integrative review of peer-reviewed academic literature following a systematic search design.

Data Sources: Qualitative, quantitative, and mixed methods publications in CINAHL, Cochrane Library, Web of Science, Embase, ERIC, and PubMed.

Review Methods: Search results were screened for full text and assessed for quality using the Mixed Methods Assessment Tool.

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(1) Background: The primary objective of this study was to examine the rate of genetic referral, BRCA testing, and BRCA positivity amongst all patients with high-grade serous ovarian cancers (HGSOC) from 2004-2019. The secondary objective was to analyze secondary factors that may affect the rates of referral and testing. (2) Methods: This population-based cohort study included all women diagnosed with HGSOC using the Manitoba Cancer Registry, CervixCheck registry, database at Manitoba Health, the Hospital Discharge abstract, the Population Registry, and Winnipeg Regional Health Authority genetics data.

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Aims And Objectives: Explore families' experiences when being approached for organ donation authorisation after brainstem death.

Background: The complexities of potential organ donor families' experiences include challenges related to emotional distress, coping with the loss and the organ donation decision-making process, and support needed. A lack of conceptual clarity was found concerning families' experiences when being approached for organ donation authorisation, which guided the study.

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  • A study analyzed the impact of molecular classification on the management of endometrial cancer patients by examining data from 1,357 cases diagnosed in 2016 across Canada, revealing significant molecular subtype diversity.
  • Only a small percentage of patients underwent necessary immunohistochemistry (IHC) testing for MMR and p53 proteins, leading to missed opportunities for early diagnosis and treatment options.
  • The findings highlight the need for standardized biomarker reporting and routine integration of molecular subtyping in pathology practice to improve patient outcomes.
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Background: The Refugee Health Program (RHP) is a nurse-led community initiative, introduced in 2005 with the aim of responding to complex health issues of refugees arriving in Victoria, Australia. Little is known about refugee health nursing in the resettlement context and the impact of dedicated refugee healthcare.

Aim: To explore the experiences and perspectives of Refugee Health Nurses (RHNs), Refugee Health Managers (managers) and refugees, gaining insight into professional relationships and the complexities of offering a specialised refugee health service.

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  • The study aimed to analyze the differences in management practices for endometrial cancer (EC) across Canada and evaluate how molecular classification could improve patient care.
  • Data was collected from 1336 EC patients across various cancer centers, revealing significant variations in surgical practices, preoperative imaging, and use of adjuvant therapies.
  • The findings suggest that molecular subtyping can enhance treatment consistency and patient outcomes, addressing discrepancies in care and improving risk assessment.
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Early mobilisation of mechanically ventilated patients has been suggested to be effective in mitigating muscle weakness, yet it is not a common practice. Understanding staff experiences is crucial to gain insights into what might facilitate or hinder its implementation. In this constructivist grounded theory study, data from two Scottish intensive care units were collected to understand healthcare staff experiences relating to early mobilisation in mechanical ventilation.

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New method can pull rare earth elements from electronic waste and coal ash.

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Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however, little is known about repertoire aging in other immune compartments, or in species other than humans. Here, we perform the first study of immune-repertoire aging in an emerging model of vertebrate aging, the African turquoise killifish ().

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Aims And Objectives: To explore nurses' experiences when approaching families for organ donation authorisation to guide nursing practice.

Background: Organ donation after brainstem death implies that bereaved families are approached to discuss organ donation authorisation, and in many countries, specialist nurses do this approach. The literature describes the social, psychological and emotional challenges of health professionals in this role.

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