Traditional depression detection methods typically rely on single-modal data, but these approaches are limited by individual differences, noise interference, and emotional fluctuations. To address the low accuracy in single-modal depression detection and the poor fusion of multimodal features from electroencephalogram (EEG) and speech signals, we have proposed a multimodal depression detection model based on EEG and speech signals, named the multi-head attention-GCN_ViT (MHA-GCN_ViT). This approach leverages deep learning techniques, including graph convolutional networks (GCN) and vision transformers (ViT), to effectively extract and fuse the frequency-domain features and spatiotemporal characteristics of EEG signals with the frequency-domain features of speech signals.
View Article and Find Full Text PDFCovalent modification is an effective strategy for reducing allergenicity to individual allergens, but there are few studies on this strategy modifying specific amino acids within epitopes under the influence of food matrix. This study used fucoidan to covalently modify shrimp () and combined mass spectrometry and bioinformatics techniques to explore epitope modification. The results showed that lower concentrations (<2.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
Superwetting surfaces have attracted considerable attention in analytical fields due to their unique ability to concentrate target analytes within evaporating droplets, characterized by a constant contact angle and a centripetal mobile contact line. While previous studies have underscored the resistance of superslippery surfaces to the coffee-ring effect, our research presents a novel strategy that dynamically introduces the coffee-ring effect on such surfaces for visual detection. By harnessing the synergistic interaction between the coffee-ring effect and the mobile contact line properties of the superslippery surface, our work leverages affinity recognition between the functionalized surface and the target analyte within the droplet to dynamically create defects for contact line pinning, thereby generating coffee rings on the superslippery surface and enabling qualitative visual detection based on their distinct patterns.
View Article and Find Full Text PDFA series of marchantin C-NO donor hybrids were designed, synthesized, and evaluated for their antitumor activity and . Notably, MC-furoxan hybrid exhibited the best selective inhibitory activity against MCF-7/ADR (IC = 0.024 μM) with 883 times potency compared with MCF-7 cells (IC = 21.
View Article and Find Full Text PDFStudies have substantiated that dietary-fat- and fructose-overconsumption-caused lipid metabolism disorders can trigger renal lipotoxicity to drive the progression of chronic kidney disease (CKD). This study was conducted to evaluate the efficacy of morroniside, a natural active substance extracted from the fruit of , in inhibiting the progression of CKD in high-fat and high-fructose-fed mice. Our results showed histological changes such as fatty degeneration of renal tubular cells, tubular dilatation, glomerular fibrosis, and abnormal renal function in the kidneys of high-fat- and high-fructose-fed mice, which was significantly improved after morroniside treatment.
View Article and Find Full Text PDFWalnut canker is a common disease in the Xinjiang Uygur autonomous region of China, which is caused by . To date, there is no effective control measure for this disease. Infection with mycoviruses has been widely proven to reduce the virulence of plant pathogenic fungi, with some mycoviruses even serving as potential biological control agents for plant diseases.
View Article and Find Full Text PDFResistance to tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) of cancer cells is a main obstacle for the chemotherapy. NRH: quinone oxidoreductase 2 (NQO2), known as a chemopreventive target, has emerged as a promising therapeutic target for overcoming TRAIL resistance in non-small cell lung cancer (NSCLC). Here we report the design, synthesis and evaluation of resveratrol analogues as novel selective NQO2 inhibitors, and analogue 20b, with potent NQO2 inhibitory activity (IC = 95 nM) and relatively low cytotoxicity, displayed synergistic lethal effects in combination with TRAIL on TRAIL-resistant NSCLC cells.
View Article and Find Full Text PDFPhthalates have been reported to increase the risk of various hormone-dependent cancers. However, there is still a lack of evidence regarding the association between phthalates and overall survival (OS) in advanced high-grade serous ovarian cancer (HGSOC). This study investigated the relationship between urinary phthalate metabolites and OS in patients with HGSOC using a nested case-control study within the Ovarian Cancer Follow-Up Study.
View Article and Find Full Text PDFRetinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) and cyclic GMP-AMP synthase (cGAS) recognize aberrant nucleic acids and initiate antiviral responses. Host factor zinc finger CCHC domain-containing protein 3 (ZCCHC3) positively regulates both RLRs- and cGAS-mediated signaling through unknown mechanisms. Here, we show that ZCCHC3 employs a broad and unified strategy to promote these pathways in human cell lines.
View Article and Find Full Text PDFHeat shock protein 90 (HSP90) is a promising target for oncology therapeutics. Over the past decades, several small molecule inhibitors have demonstrated significant antitumor activity in clinical trials. However, nearly all HSP90 inhibitors in clinical trials have failed due to toxicity or insufficient efficacy.
View Article and Find Full Text PDFFood allergy has become a global food safety issue, and inducing tolerance of the immune system to allergens is seen as an effective way to address this problem. In this study, shrimp () was covalently modified with fucoidan to explore its potential as an oral tolerance inducer. The results showed that this strategy not only had no adverse effect on the growth of mice but also achieved significant immune tolerance induction effects.
View Article and Find Full Text PDFThis study examined the effects of sodium bicarbonate (SC), curcumin (CC), and their combination (CC + SC) on the structural and gel properties of bovine myofibrillar proteins (MPs) under oxidative conditions. The results demonstrated that the addition of CC and SC significantly reduced carbonyl formation associated with protein oxidation (P < 0.05), with the combination of CC + SC showing the strongest inhibitory effect.
View Article and Find Full Text PDFBackground: Osteoarthritis (OA) is a chronic joint condition that causes pain, limited mobility, and reduced quality of life, posing a threat to healthy aging. Early detection is crucial for improving prognosis. Recent research has focused on the role of ubiquitination-related genes (URGs) in early OA prediction.
View Article and Find Full Text PDFBackground: RANKL and SCLEROSTIN antibodies have provided a strong effective choice for treating osteoporosis in the past years, which suggested novel molecular target identification and therapeutic strategies development are important for the treatment of osteoporosis. The therapeutic effect of verapamil, a drug previously used for cardiovascular diseases, on diabetes was due to the inhibition of TXNIP expression, which has also been reported as a target in mice osteoporosis. Whether verapamil-inhibited TXNIP expression is related to osteoporosis and how it works on the molecular level is worthy to be explored.
View Article and Find Full Text PDFThere is different administration routes of triamcinolone acetonide (TA) administration for macular edema, but the efficacy ranking remains unclear. The purpose of this study is to assess the efficacy of different administration routes of TA employed in macular edema. PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials were systematically searched for published articles comparing macular edema in patients with triamcinolone acetonide in different administration.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Globally, breast cancer represents the most common cancer and the primary cause of death by cancer in women. Lipids are crucial in human physiology, serving as vital energy reserves, structural elements of biological membranes, and essential signaling molecules. The metabolic reprogramming of lipid pathways has emerged as a critical factor in breast cancer progression, drug resistance, and patient prognosis.
View Article and Find Full Text PDFIntroduction: Bone homeostasis between osteoclast bone resorption and osteoblastic bone formation is tightly regulated by a series of factors such as the receptor activator of nuclear factor-κB ligand (RANKL). Denosumab that neutralizes RANKL is effective and widely applied in the treatment of postmenopausal osteoporosis. However, factors that participated in the RANKL-related bone remodeling process in primary and secondary osteoporosis are less known.
View Article and Find Full Text PDFBackground: Computed tomography (CT) plays a crucial role in assessing chronic rhinosinusitis, but lacks objective quantifiable indicators.
Objective: This study aimed to use deep learning for automated sinus segmentation to generate distinct quantitative scores and explore their correlations with disease-specific quality of life.
Methods: From July 2021 to August 2022, 445 CT data were collected from 2 medical centers.
Unlabelled: The KREMEN1 (KRM1) protein is a cellular receptor for multiple enteroviruses that cause hand, foot, and mouth disease (HFMD), including coxsackievirus CVA2, CVA3, CVA4, CVA5, CVA6, CVA10, and CVA12. The molecular basis for the broad recognition of these viruses by the KRM1 receptor remains unclear. Here, we report the indispensable role of the completely conserved VP2 capsid protein residue K140 (designated K2140) in mediating receptor recognition and infection by CVA10 and other KRM1-dependent enteroviruses.
View Article and Find Full Text PDFGen Comp Endocrinol
February 2025
The melanocortin-3 receptor (MC3R) was recognized for its critical role in energy metabolism and inflammatory responses in mammals; however, its functions in fish remain poorly understood. This study characterized the mc3r gene in goldfish, investigating its sequence, tissue distribution, and pharmacological responses. The coding sequence of goldfish mc3r was 975 bp, translating to a 325-amino-acid protein typical of G protein-coupled receptors, with notable conservation across cyprinids.
View Article and Find Full Text PDFThe goji fruit fly, , is a major pest on the well-known medicinal plant . Dissecting the molecular mechanisms of the oviposition selection of regarding the host plant will help to identify new strategies for pest fly control. However, the molecular mechanism of chemical communication between the goji fruit fly and the host goji remains unclear.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS), commonly known as motor neuron disease, is a neurodegenerative disorder characterized by the progressive degeneration of both upper and lower motor neurons. This pathological process results in muscle weakness and can culminate in paralysis. To date, the precise etiology of ALS remains unclear.
View Article and Find Full Text PDFSingle-crystal structures of four alditol complexes are presented. In LuCl/galactitol and ScCl/-inositol complexes, μ-bridge-relevant deprotonations were observed. The polarization from two rare earth ions in the μ-bridge activates the chemically inert OH and promotes deprotonation.
View Article and Find Full Text PDFThe present study aims to summarize the current biomarker landscape in gynecological cancers (GCs) and incorporate bioinformatics analysis to highlight specific biological processes. The literature was retrieved from PubMed, Web of Science, Embase, Scopus, Ovid Medline, and Cochrane Library. The final search was conducted on December 7, 2022.
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