Visual cortex encodes timing information in humans and mice.

Despite the importance of timing in our daily lives, our understanding of how the human brain mediates second-scale time perception is limited. Here, we combined intracranial stereoelectroencephalography (SEEG) recordings in epileptic patients and circuit dissection in mice to show that visual cortex (VC) encodes timing information. We first asked human participants to perform an interval-timing task and found VC to be a key timing brain area.

Erratum: Preventing tumor progression to the bone by induced tumor-suppressing MSCs: Erratum.

[This corrects the article DOI: 10.7150/thno.58779.

Correction: Sun et al. Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling. 2022, , 3039.

In the original article [...

Identification of circadian clock genes as regulators of immune infiltration in Hepatocellular Carcinoma.

Multiple studies have reported that the immune system is under the control of a circadian clock, especially in cancers, but how circadian clock genes shape tumor immune cell infiltration in hepatocellular carcinoma (HCC) remains unclear. The rhythmicity of circadian clock genes was investigated using the GETx database. The expression and methylation level of circadian clock genes in HCC and paracancerous was evaluated using the GETx and TCGA databases.

PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9.

Despite the advance in medications in the past decade, aggressive breast cancer such as triple-negative breast cancer is difficult to treat. Here, we examined a counter-intuitive approach to converting human bone marrow-derived mesenchymal stem cells (MSCs) into induced tumor-suppressing cells by administering YS49, a PI3K/Akt activator. Notably, PI3K-activated MSCs generated tumor-suppressive proteomes, while PI3K-inactivated MSCs tumor-promotive proteomes.

Advances in Technologies for Boron Removal from Water: A Comprehensive Review.

Boron overabundance in aquatic environment raises severe concerns about the environment and human health because it is toxic to various crops and induces many human and animal diseases with long-term consequences. In response to the boron pollution of water resources and the difficulty of eliminating boron from water for production and living purposes, this article summarizes the progress in research on boron removal technology, addressing the following aspects: (1) the reasons for the difficulty of removing boron from water (boron chemistry); (2) ecological/biological toxicity and established regulations; (3) analysis of different existing processes (membrane processes, resin, adsorption, chemical precipitation, (electric) coagulation, extraction, and combined methods) in terms of their mechanisms, effectiveness, and limitations; (4) prospects for future studies and possible improvements in applicability and recyclability. The focus of this paper is thus to provide a comprehensive summary of reported deboronation processes to date, which will definitely identify directions for the development of boron removal technology in the future.

Pyroptosis correlates with tumor immunity and prognosis.

Pyroptosis, as a proinflammatory form of regulated cell death, plays an important role in multiple cancers. However, the diagnostic and prognostic values of pyroptosis and its interaction with tumor immunity in pan-cancer are still unclear. Here, we show an elevated general expression of 17 pyroptosis-associated genes of tumor patients with high-immune-activity and a reduced pyroptosis in low-immune-activity tumors.

Wnt signaling: a double-edged sword in protecting bone from cancer.

Wnt signaling plays a critical role in loading-driven bone formation and bone homeostasis, whereas its activation in cancer cells promotes their progression. Currently, major research efforts in cancer treatment have been directed to the development of Wnt inhibitors. Recent studies on tumor-bone interactions, however, presented multiple lines of evidence that support a tumor-suppressive role of Lrp5, a Wnt co-receptor, and β-catenin, in Wnt signaling.

PGE2 pathway mediates oxidative stress-induced ferroptosis in renal tubular epithelial cells.

Prostaglandin E2 (PGE2) is one of the most abundant prostaglandins and has been implicated in various diseases. Here, we aimed to explore the role of the PGE2 pathway in mediating ferroptosis during acute kidney injury. When renal tubular epithelial cells stimulated by H O , the contents of glutathione (GSH) and glutathione peroxidase 4 (GPX4) decreased, whereas the level of lipid peroxide increased.

The role of microenvironment in stem cell-based regeneration of intervertebral disc.

Regenerative medicine for intervertebral disc (IVD) disease, by utilizing chondrocytes, IVD cells, and stem cells, has progressed to clinical trials in the treatment of back pain, and has been studied in various animal models of disc degeneration in the past decade. Stem cells exist in their natural microenvironment, which provides vital dynamic physical and chemical signals for their survival, proliferation and function. Long-term survival, function and fate of mesenchymal stem cells (MSCs) depend on the microenvironment in which they are transplanted.

Carbon Quantum Dots-Functionalized UiO-66-NH Enabling Efficient Infrared Light Conversion of 5-Hydroxymethylfurfuryl with Waste Ethanol into 5-Ethoxymethylfurfural.

The catalytic etherification of 5-hydroxymethylfurfural (HMF) with the waste ethanol into high-energy-density 5-ethoxymethylfurfural (EMF) has been considered as a promising way to simultaneously alleviate the energy crisis and environmental pollution. However, the energy consumption is rather high as the synthesis of EMF requires a high temperature to open the etherification reaction. Herein, we demonstrate a clever design and construction of acidified biomass-derived carbon quantum dots (BCQDs)-modified UiO-66-NH that is immobilized on cermasite (H/BCQDs/UiO-66-NH@ceramsite), which can use the IR light as driven energy and wasted ethanol to trigger the catalytic conversion of HMF into EMF.

Double Gain: The Radio Frequency Catheter Ablation of Ventricular Aneurysm Related Recurrent Ventricular Tachycardia on a Tremendous Cardiac Outpouching.

Dilated cardiomyopathy (DCM) is a classic type of non-ischemic cardiomyopathy. Of these, idiopathic cardiomyopathy (IDCM) is a rare type of non-genetic dilated cardiomyopathy. More specifically, the patient had suspected IDCM combined with sustained polymorphic ventricular tachycardia (PMVT) of left ventricular basal segmental origin, cardiac systolic dysfunction and an ejection fraction (EF) of 29%.

Identification of MRI features associated with injury type, severity, and prognosis in drug-induced liver injury.

Objectives: To identify magnetic resonance imaging (MRI) features associated with injury type, severity, and liver transplantation (LT)/liver-related death (LRD) in drug-induced liver injury (DILI).

Methods: The eligible DILI patients (2016 to 2020) who underwent contrast abdominal MRI within 3 months of onset were retrospectively analysed at Beijing Friendship Hospital, Capital Medical University. The MRI features independently associated with severity and prognosis were identified by backwards logistic regression.

Carbon-based photocatalysts for hydrogen production: A review.

Future energy crises and environmental deterioration may only be avoided by converting solar energy into sustainable, safe, cost-effective, and environmentally friendly technologies such as water splitting. Many researchers and governments throughout the globe have stressed the imperative need for affordable, environmental benign, resistive to corrosion, and earth-abundant nanostructured photocatalysts. This has led scientists to look for a green and cost-effective way to generate energy.

Spatial and interdecadal differences in climatic suitability for winter wheat in China from 1985 to 2014.

The evident climate jump after 2000 in China may have greatly influenced the production of winter wheat, which is one of the nation's major grain crops. To evaluate the impacts of climate change on winter wheat production and identify the climatic factors primarily responsible, we used daily meteorological data from 2244 stations and integrated indicators to examine the decadal changes in the potential plantable zone (PPZ), growth periods, and climatic suitability for winter wheat in China from 1985 to 1999 and from 2000 to 2014. The results showed the following: (1) The PPZ has decreased by approximately 9%, and the main reason may be the increased frequency of extreme cold events in northern China from 2000 to 2014.

Safety and Effectiveness of Moxibustion and Abdominal Massage in Hospitalized Older Patients With Constipation: A Retrospective Study.

Background: Evidence about moxibustion and abdominal massage for treating constipation in older hospitalized patients is limited.

Purpose: To investigate the safety and effectiveness of moxibustion and abdominal massage in hospitalized older patients with constipation.

Methods: Hospitalized older patients (age ≥60 years) with constipation were retrospectively categorized as 2 cohorts according to whether the patients received moxibustion and abdominal massage in addition to routine nursing care.

Genome-Wide Characterization of the Aquaporin Gene Family in Radish and Functional Analysis of Involved in Salt Stress.

Aquaporins (AQPs) constitute a highly diverse family of channel proteins that transport water and neutral solutes. play crucial roles in plant development and stress responses. However, the characterization and biological functions of in radish ( L.

Identification evidence unraveled by strict proteomics rules toward forensic samples.

Snake venom is a complex mixture of proteins and peptides secreted by venomous snakes from their poison glands. Although proteomics for snake venom composition, interspecific differences, and developmental evolution has been developed for a decade, current diagnosis or identification techniques of snake venom in clinical intoxication and forensic science applications are mainly dependent on morphological and immunoassay. It could be expected that the proteomics techniques directly offer great help.

Incipient Sympatric Speciation and Evolution of Soil Bacteria Revealed by Metagenomic and Structured Non-Coding RNAs Analysis.

Soil bacteria respond rapidly to changes in new environmental conditions. For adaptation to the new environment, they could mutate their genome, which impacts the alternation of the functional and regulatory landscape. Sometimes, these genetic and ecological changes may drive the bacterial evolution and sympatric speciation.

Ferroptosis Associates With Diagnosis and Prognosis by Promoting Antitumor Immune Response in Melanoma.

Immunotherapy has greatly improved the clinical benefits of cancer treatment, especially in melanoma. Ferroptosis is a novel mechanism of cell death which relates to immunity. This study aimed at understanding the potential link between ferroptosis and cancer immunocompetent in melanoma using multiple bioinformatics analyses.

Retrospective Study of Aging and Sex-Specific Risk Factors of COVID-19 with Hypertension in China.

Background: Coronavirus disease 2019 (COVID-19) has been a global threat that pushes healthcare to its limits. Hypertension is one of the most common risk factors for cardiovascular complications in COVID-19 and is strongly associated with disease severity and mortality. To date, clinical mechanisms by which hypertension leads to increased risk in COVID-19 are still unclear.

Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling.

Purpose: To develop a novel treatment option for Chondrosarcoma (CS) and inflammatory arthritis, we evaluated a counterintuitive approach of activating tumorigenic and inflammatory signaling for generating joint-protective proteomes.

Methods: We employed mesenchymal stem cells and chondrocytes to generate chondroprotective proteomes by activating PI3K signaling and the administration of TNFα. The efficacy of the proteomes was examined using human and mouse cell lines as well as a mouse model of CS.

Systematic review of mental health symptom changes by sex or gender in early-COVID-19 compared to pre-pandemic.

Women and gender-diverse individuals have faced disproportionate socioeconomic burden during COVID-19. There have been reports of greater negative mental health changes compared to men based on cross-sectional research that has not accounted for pre-COVID-19 differences. We compared mental health changes from pre-COVID-19 to during COVID-19 by sex or gender.