P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult.

P2X7 receptor (P2X7R) plays an important role in modulating inflammation and fibrosis, but information is limited whether Zusanli (ST36) can inhibit inflammation and fibrosis by regulating P2X7R. Isoprenaline at 5 mg/kg was subcutaneously injected to wild-type and P2X7R knockout mice for 7 days, while treatment groups received electroacupuncture (EA) stimulation at ST36 for 7 sessions. Following 7-session treatment, Masson's trichrome staining was performed to assess the fibrosis.

Neural mechanisms of attentional bias to emotional faces in patients with chronic insomnia disorder.

Objective: This study used event-related potential (ERP) and resting-state functional connectivity (rs-FC) approaches to investigate the neural mechanisms underlying the emotional attention bias in patients with chronic insomnia disorder (CID).

Methods: Twenty-five patients with CID and thirty-three demographically matched healthy controls (HCs) completed clinical questionnaires and underwent electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) scans. EEG analysis examined the group differences in terms of reaction times, P3 amplitudes, event-related spectral perturbations, and inter-trial phase synchrony.

Immunobiological properties and structure analysis of group 13 allergen from Blomia tropicalis and its IgE-mediated cross-reactivity.

Blomia tropicalis is an important species of allergenic mite. Structurally related cross-reactive allergens are involved in pathogenesis of clinical symptoms. The present study focused on recombinant allergen rBlo t 13 from B.

Sepsis-Induced Acute Lung Injury Is Alleviated by Small Molecules from Dietary Plants via Pyroptosis Modulation.

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and mortality, and it has three major pathogeneses, namely alveolar-capillary barrier destruction, elevated gut permeability, and reduced neutrophil extracellular traps (NETS), all of which are pyroptosis-involved. Due to limitations of current agents like adverse reaction superposition, inevitable drug resistance, and relatively heavier financial burden, naturally extracted small-molecule compounds have a broad market even though chemically modified drugs have straightforward efficacy. Despite increased understanding of the molecular biology and mechanism underlying sepsis-induced ARDS, there are no specific reviews concerning how small molecules from dietary plants alleviate sepsis-induced acute lung injury (ALI) via regulating pyroptotic cell death.

dECM based dusal-responsive vascular graft with enzyme-controlled adenine release for long-term patency.

Rapid occlusion is the culprit leading to implantation failure of biological blood vessels. Although adenosine is a clinical-proven drug to overcome the problem, its short half-life and turbulent burst-release limit its direct application. Thus, a pH/temperature dual-responsive blood vessel possessed controllable long-term adenosine secretion was constructed based on acellular matrix via compact crosslinking by oxidized chondroitin sulfate (OCSA) and functionalized with apyrase and acid phosphatase.

[Effect of electroacupuncture on Notch/NF-κB signaling pathway in colonic mucosa of mice with ulcerative colitis].

Objective: To observe the protective effect of electroacupuncture (EA) on the intestinal mucosal barrier and its relationship with the Notch/NF-κB signaling pathway in mice with ulcerative colitis (UC), so as to explore its mechanism of treating UC.

Methods: Male C57BL/6J mice were randomized into control, model and EA groups, with 6 mice in each group. The UC model was established by giving the mice with 2% Dextran Sulfate Sodium (DSS) for 7 days.

Characteristics and Evolution Mechanism of Three Phase Products of Lignite by Hydrothermal Treatment Dewatering.

Baiyinhua lignite was treated by hydrothermal treatment dewatering (HTD). The production characteristics of the gas, solid, and liquid were studied. Results show that HTD is an effective means to decrease water content and water-holding capacity.

Biochemical and structural characterization of a KTSC family single-stranded DNA-binding protein from Euryarchaea.

The lysine (K) tRNA synthetase C-terminal (KTSC) domain containing proteins are widely spread in Bacteria, Archaea and Viruses, but the function of this short domain is unclear. The occurrence of the fusion of KTSC domain to a catalytic domain or domains related to DNA or RNA metabolisms suggests its potential role in DNA or RNA binding. Here, we report the characterization of Mvu8s from Methanolobus vulcani, which consists of a single KTSC domain.

Structural and functional characterization of the deep-sea thermophilic bacteriophage GVE2 tailspike protein.

The genome of the thermophilic bacteriophage GVE2 encodes a putative tailspike protein (GVE2 TSP). Here we report the crystal structure of the truncated GVE2 TSP at 2.0-Å resolution lacking 204 amino acid residues at its N-terminus (ΔnGVE2 TSP), possessing a "vase" outline similar to other TSP's structures.

The complete mitochondrial genome sequence of Lindian Chicken () in China.

In this study, the first complete mitochondrial genome of Lindian Chicken () was sequenced in order to develop the mitogenome data for genus gallus. The complete mitogenome sequence is 16,785 bp in length, containing 37 genes (13 protein-coding genes, 2 ribosomal RNA, 22 transfer RNA genes, and one control region). The new sequenced complete mitogenome of Lindian Chicken will provide useful information for application in conservation genetics and evolution for this Near Threatened Chicken genomes.

The Belisana spiders (Araneae: Pholcidae) from Xishuangbanna Tropical Botanical Garden, Yunnan, China.

Five new species of the spider genus Belisana Thorell, 1898 are described based on material collected in the Xishuangbanna Tropical Botanical Garden (Yunnan, China). They are: B. dian Yao Li sp.

Five new species of the spider genus Pholcus Walckenaer, 1805 (Araneae: Pholcidae) from China and Thailand.

Five new species from four species-groups of the genus Pholcus Walckenaer, 1805 are described from China and Thailand: P. sakaew Yao Li sp. nov.

[Application of Vc fermentation waste residue on prevention and control of plant diseases in protective ground].

The prevention and control of tomato plant diseases were conducted in protective ground using Vc fermentation waste residue treated by enzymolysis and ultrasonic wave. The results showed that the seedlings planted for 3 weeks on the protective ground soil continuously cropped tomato plant for 9 years and fertilized 75, 150 and 300 kg.hm-2 grew well.

[Diversity of the microorganisms degrading aromatic hydrocarbons].

Aromatic hydrocarbons are biological xenobiotics. Indigenous microorganism groups turn from being unfamiliar with into active response to environmental changes by their adaptability to environment. There are changes in their genetic background, and then, the biodiversity turns into being.

[Microbiological eco-regulation in Vc two-step fermentation].

The growth and interaction of Gluconobacter axydans and Bacillus megaterium in Vc two step fermentation have been studied. The results showed that there is a kind of coordinate symbiosis between G. axydans and B.