multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors.

Neurochemical signals like dopamine (DA) play a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex networks has been hindered by the challenge of detecting multiple neurochemicals simultaneously. To overcome this limitation, we developed a single-protein chemigenetic DA sensor, HaloDA1.

A novel approach for agricultural carbon emission reduction by integrating fermatean neutrosophic set with WINGS and AHP-EWM.

Agriculture is a major contributor to global greenhouse gas emissions, highlighting the urgent need for effective carbon reduction strategies. This study presents an innovative integrated model that employs Fermatean Neutrosophic Set in conjunction with the Weighted Influence Nonlinear Gauge System and the Analytic Hierarchy Process combined with the Entropy Weight Method to assess key factors influencing agricultural carbon reduction. Our study delineates the hierarchical importance of factors influencing carbon emissions, with carbon emission reduction policy (τ4) emerging as the paramount factor, attributed a value of 0.

How Do DNA Molecular Springs Modulate Protein-Protein Interactions: Experimental and Theoretical Results.

Deoxyribonucleic acid (DNA) nanomachines have been widely exploited in enzyme activity regulation, protein crystallization, protein assembly, and control of the protein-protein interaction (PPI). Yet, the fundamental biophysical framework of DNA nanomachines in the case of regulating protein-protein interactions remains elusive. Here, we established a DNA nanospring-mCherry model with mCherry homodimers of different .

Promoting agricultural sustainable development by a novel integrated pythagorean neutrosophic and WINGS-BWM model.

This paper identifies nine factors affecting agricultural sustainable development by reading extensive literature and invites five experts to assess these factors using the pythagorean neutrosophic linguistic variable. Some of these factors can directly reduce the environmental footprint of agriculture, improve soil health, and promote biodiversity, while others can indirectly integrate to support the adoption of sustainable practices, further mitigating environmental degradation. Collectively, these factors reinforce ecological balance and play a critical role in advancing agricultural sustainable development.

Effect of Combining Wuyiencin and Pyrimethanil on Controlling Grape Gray Mold and Delaying Resistance Development in .

By screening the compounding combination of Wuyiencin and chemical agents, this study aims to delay the emergence of chemical agent resistance, and provide a technical reference for scientific and rational fungicides technology. This study investigated the impacts of the antibiotic wuyiencin derived from var. and its combination with pyrimethanil on the inhibition of .

Membrane protein Bcsdr2 mediates biofilm integrity, hyphal growth and virulence of Botrytis cinerea.

Grey mould caused by Botrytis cinerea is a devastating disease responsible for large losses to agricultural production, and B. cinerea is a necrotrophic model fungal plant pathogen. Membrane proteins are important targets of fungicides and hotspots in the research and development of fungicide products.

Acute kidney injury after radical gastrectomy: incidence, risk factors, and impact on prognosis.

Background: Acute kidney injury (AKI) is a serious adverse event often overlooked following major abdominal surgery. While radical gastrectomy stands as the primary curative method for treating gastric cancer patients, little information exists regarding AKI post-surgery. Hence, this study aimed to ascertain the incidence rate, risk factors, and consequences of AKI among patients undergoing radical gastrectomy.

Research on the spatio-temporal coupling relationship between agricultural green development efficiency and food security system in China.

Food security and agricultural green development are fundamental issues concerning the survival of mankind. To realize the coordinated development of them is of great significance to promote the green transformation of agriculture and ensure national food security. However, few studies have analyzed the coupling relationship between agricultural green development and food security.

A novel approach for melanoma detection utilizing GAN synthesis and vision transformer.

Background And Objective: Melanoma, a malignant form of skin cancer, is a critical health concern worldwide. Early and accurate detection plays a pivotal role in improving patient's conditions. Current diagnosis of skin cancer largely relies on visual inspections such as dermoscopy examinations, clinical screening and histopathological examinations.

Imaging classification of prostate cancer with extracapsular extension and its impact on positive surgical margins after laparoscopic radical prostatectomy.

Abstract: To explore the impact of different imaging classifications of prostate cancer (PCa) with extracapsular extension (EPE) on positive surgical margins (PSM) after laparoscopic radical prostatectomy.

Methods: Clinical data were collected for 114 patients with stage PT3a PCa admitted to Ningbo Yinzhou No. 2 Hospital from September 2019 to August 2023.

N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes.

CircRNAs play multiple roles in a variety of cellular processes. We found that Circ-CDYL is highly enriched in early HCC plasma exosomes. Moreover, EpCAM HCC cells and exosomes had significant Circ-CDYL levels.

Bipolar neutrosophic WINGS for green technology innovation.

Green technology innovation is a crucial assurance of achieving sustainable economic and environmental development, so improving the capability of green technology innovation is an urgent problem. In order to provide a more objective and accurate tool for identifying the most important impact factor of green technology innovation, this study innovatively proposes a new method by combining the bipolar neutrosophic sets with Weighted Influence Nonlinear Gauge System (WINGS) method. Furthermore, this paper intends to provide recommendations in improving green technology innovation capability.

Membrane Protein Bcest Is Involved in Hyphal Growth, Virulence and Stress Tolerance of .

is a necrotrophic model fungal plant pathogen that causes grey mould, a devastating disease responsible for large losses in the agriculture sector. As important targets of fungicides, membrane proteins are hot spots in the research and development of fungicide products. We previously found that membrane protein Bcest may be closely related to the pathogenicity of .

Enhancing wuyiencin productivity of Streptomyces albulus (CK15) by mutagenesis breeding with atmospheric and room temperature plasma.

Streptomyces species are known for their ability to efficiently produce secondary metabolites, including various antibiotics. Wuyiencin, an antibiotic produced by Streptomyces albulus CK15, is commonly used in agriculture to control fungal diseases in crops and vegetables. In this study, we utilized atmospheric and room temperature plasma (ARTP) mutagenesis to generate mutant S.

Multivalued neutrosophic power partitioned Hamy mean operators and their application in MAGDM.

The novel multivalued neutrosophic aggregation operators are proposed in this paper to handle the complicated decision-making situations with correlation between specific information and partitioned parameters at the same time, which are based on weighted power partitioned Hamy mean (WMNPPHAM) operators for multivalued neutrosophic sets (MNS) proposed by combining the Power Average and Hamy operators. Firstly, the power partitioned Hamy mean (PPHAM) is capable of capture the correlation between aggregation parameters and the relationship among attributes dividing several parts, where the attributes are dependent definitely within the interchangeable fragment, other attributes in divergent sections are irrelevant. Secondly, because MNS can effectively represent imprecise, insufficient, and uncertain information, we proposed the multivalued neutrosophic PMHAM (WMNPHAM) operator for MNS and its partitioned variant (WMNPPHAM) with the characteristics and examples.

Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer.

Diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC) are the major histological types of gastric cancer (GC). The molecular mechanism underlying DGC and IGC differences are poorly understood. In this research, we carry out multilevel proteomic analyses, including proteome, phospho-proteome, and transcription factor (TF) activity profiles, of 196 cases covering DGC and IGC in Chinese patients.

Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study.

Aims: To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).

Methods: This prospective observational study enrolled patients with T2DM at the Second Hospital of Jilin University between December 2021 and March 2022. DKD was measured by the urinary albumin-to-creatinine ratio.

The clinical outcomes of extended resections in patients with IV stage gallbladder cancers: A retrospective study from a large tertiary center.

Background And Aim: The role of extended resections in patients with clinical stage IV gallbladder cancer (GBC) remains unclear. This study retrospectively analyzed the clinical outcomes of patients who underwent extended resections for IV GBC.

Methods: Patients who were diagnosed with IV stage GBCs and underwent extended resections in Eastern Hepatobiliary Surgery Hospital, Shanghai, China, were retrospectively included in our study.

Defining the impact of platelet-to-lymphocyte ratio on patient survival with gastric neuroendocrine neoplasm: a retrospective cohort analysis.

Background: Gastric neuroendocrine neoplasm (g-NEN) is a rare but heterogeneous neoplasm, with an increasing incidence yearly. Conventional prognostic markers of g-NEN remain limited which could only be detected after surgery. There is an urgent need to explore new prognostic markers for g-NEN patients.

Comparison of short-term efficacy between totally laparoscopic gastrectomy and laparoscopic assisted gastrectomy for elderly patients with gastric cancer.

Background: Totally laparoscopic gastrectomy (TLG) entails both gastrectomy and gastrointestinal reconstruction under laparoscopy. Compared with laparoscopic assisted gastrectomy (LAG), TLG has been demonstrated in many studies to require a smaller surgical incision, result in a faster postoperative recovery and less pain and have comparable long-term efficacy, which has been a research hotspot in recent years. Whether TLG is equally safe and feasible for elderly patients remains unclear.

An integrated rough-fuzzy WINGS-ISM method with an application in ASSCM.

Environmental deterioration, the COVID-19 pandemic and the Russian-Ukrainian conflict had brought chronic and dramatic impacts on agricultural supply chain around the world, resulting in high inflation rates and unavoidable costs. In order to reduce the adverse impacts and achieve sustainability in agricultural supply chain, it's necessary to scientifically explore composite indicators interlinked with agricultural sustainable supply chain management (ASSCM). The current study developed an integrated rough-fuzzy WINGS-ISM method to reveal the hierarchal and causal structure of indicators.

Exosomal MicroRNA signature acts as an efficient biomarker for non-invasive diagnosis of gallbladder carcinoma.

Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR-552-3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p. When validated in 102 GBC patients and 112 chronic cholecystitis patients from multiple medical centers, the AUC of this combinatorial biomarker was 0.905, with a sensitivity of 81.

The global research status and trends of the application of endoscopic ultrasonography in pancreatic tumors over the last decades: A bibliometric study.

Background: To describe the development process and structural relationships of scientific achievements in endoscopic ultrasonography (EUS) in pancreatic tumors over the past decades and to reveal the key research topics using bibliometric analysis.

Methods: All relevant publications covering the research of EUS in pancreatic tumors from 1984 to 2021 were involved through the Web of Science Core Collection. R-bibliometrix was used to conduct the bibliometric analysis, and VOSviewer software was used to explore the hot spots and networks related to this field.

Rspondin-1 contributes to the progression and stemness of gastric cancer by LGR5.

Gastric cancer is a one of the most common malignant tumors with poor prognosis worldwide. Leucine-rich G-protein-coupled receptor 5 (LGR5) is determined as a modulator of Wnt signaling cascade and R-spondins are a family of secretory agonists in the Wnt signaling and act as ligands to interact with LGR5. However, the function of Rspondin-1 in GC remains obscure.