Pharmacokinetics and Pharmacodynamics Modeling and Optimal Regimens Evaluation of Cefquinome Against Bovine Mastitis Caused by .

Cefquinome, the fourth-generation cephalosporin applied solely for veterinary medicine, is commonly used for bovine mastitis caused by . The present study aims to establish an optimal dose and provide a PK/PD Cutoff value (CO) for cefquinome against based on pharmacokinetics and pharmacodynamics (PK/PD) integration. This study investigated the pharmacokinetics (PK) of cefquinome when administered as three consecutive intramammary (IMM) doses of cefquinome in three healthy dairy cows at 75 mg/gland.

[Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].

Aim: To provide basic data for the synthesis of new sinomenine derivatives.

Methods: The C ring in sinomenine was modified.

Results: Seven compounds were prepared and screened for anti-inflammatory and analgesic activities.