Dual inhibition of autophagy and PI3K/mTOR pathway as a potential therapeutic strategy against laryngeal squamous cell carcinoma.

Background: New and effective chemotherapy or targeted therapy strategies are needed against laryngeal squamous cell carcinoma (LSCC). We aimed to explore the antitumor effect of dual PI3K/mTOR inhibitor combined with autophagy suppression on LSCC and its underlying mechanism.

Methods: Hep-2 and AMC-HN-8 cell lines were treated with the Akt inhibitor LY294002, mTOR inhibitor rapamycin, and dual inhibitor NVP-BEZ235 separately.

[Freezing resistance and injury indices for different cultivars of winter-spring wheat in Huang-Huai-Hai Plain. I . Comparison of freezing resistance for different cultivars of winter-spring wheat during mid-winter period].

The relationships between mortality rate and low temperature for different cultivars of winter-spring wheat during mid-winter period were identified through two-year outdoor potting experiments and indoor manually controlled freezing experiments. We defined the lethally critical temperature and the density of antifreeze capability when the mortality rate reached 10%, 20% and 50% for different cultivars of winter-spring wheat during mid-winter period. The strong-winterness wheat (Yanda 1817 and Jing 411) showed the best freezing resistance and the 50%-lethal temperatures (LT50) of these two cultivars were -21.

Malignant minor salivary gland carcinomas of the larynx.

Aims: To explore the clinical characteristics and treatment of malignant minor salivary gland carcinomas of the larynx.

Methods: Clinical patient information regarding presentation, pathology, treatment and outcome was obtained through a review of patient charts.

Results: Malignant minor salivary carcinomas in the larynx were confirmed pathologically in 15 patients (11 males, 4 females) between 2003 and 2010 in our hospital; 6 patients had mucoepidermoid carcinoma (MEC; 40%), 6 had adenoid cystic carcinoma (ACC; 40%) and 3 had adenocarcinoma (20%).

Hierarchical macroporous Zn(2)SnO(4)-ZnO nanorod composite photoelectrodes for efficient CdS/CdSe quantum dot co-sensitized solar cells.

A hierarchical macroporous Zn2SnO4-ZnO nanorod composite film is prepared through a drop-casting process of PS@Zn2SnO4 and subsequent hydrothermal growth of ZnO nanorod. CdS/CdSe co-sensitized solar cells based on the macroporous Zn2SnO4-ZnO nanorod composite photoelectrode exhibits an enhancement of 34.4% in power conversion efficiency (1.

Hydrothermal fabrication of hierarchically macroporous Zn2SnO4 for highly efficient dye-sensitized solar cells.

Hierarchical macroporous Zn(2)SnO(4) consisting of nanoparticles has been synthesized for the first time through an in situ hydrothermal and a following annealing process in the presence of a polystyrene (PS) template. Zn(2)SnO(4) macropore sizes are tuned in the range of 180-650 nm by selecting the appropriate size of PS spheres, and the building unit size of the Zn(2)SnO(4)macropore is 4.2 nm regardless of the PS sizes.

Macroporous SnO2 synthesized via a template-assisted reflux process for efficient dye-sensitized solar cells.

Macroporous SnO2 composed of small SnO2 nanoparticles with diameters around 10 nm is prepared via a reflux process. This novel structure is designed as the photoanode in dye-sensitized solar cells (DSSCs), intending to improve the light utilization efficiency with its excellent light scattering ability. Though the dye adsorption of macroporous SnO2 (14.

Fast onset of action of sublingual immunotherapy in house dust mite-induced allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial.

Objectives/hypothesis: To investigate how quickly an allergic rhinitis (AR) patients' symptoms will improve with sublingual immunotherapy (SLIT).

Study Design: Double-blind placebo study.

Methods: This is a multicenter, randomized, double-blind, placebo-controlled study of SLIT used to treat house dust mite-induced AR.

[Characteristics of agricultural climate resources in three provinces of northeast China under global climate change].

Based on the 1961-2007 weather data from 72 meteorological stations in three provinces of Northeast China, the change characteristics of agricultural climatic factors including yearly and temperature-defined growing season's mean air temperature, > or =10 degrees C accumulated temperature, precipitation, reference evapotranspiration, and sunshine hours were analyzed. In 1961-2007, the yearly mean air temperature in the three provinces had an increasing trend, with a rate of 0.38 degrees C x 10 a(-1).

[Treatment of glottic cancer with CO2 laser].

Objective: To discuss the indications, surgical technique and complications of CO2 laser in the treatment of glottic cancer.

Methods: Sixty cases of glottic cancer (T1 = 52, T2 = 8) operated with CO2 laser between 2003 and 2006 were retrospectively analyzed.

Results: All patients had remarkable hoarseness after the surgery.