[Etiologic analysis of 487 cases of ophthalmoplegia].

Objective: To study the etiology of ophthalmoplegia cases.

Methods: A retrospective case series study. We summarized and analyzed etiological diagnosis of 487 ophthalmoplegia patients from January 2005 to September 2010 in Beijing Tongren Hospital of Capital Medical University and Beijing Tongren Eye Center.

[Clinical characteristic of optic neuritis and its relevancy with human leukocyte antigen].

Objective: To investigate clinical characteristics of optic neuritis and its association with HLA (human leukocyte antigen).

Method: The clinical data of 42 patients with optic neuritis were collected and flow polymerase chain reaction-reverse sequence specific oligonucleotide probe (PCR-rSSOP) was used to determine the genotype of HLA-DRB1.

Results: Two patients confirmed as Leber hereditary optic neuropathy by gene sequencing were excluded from the study.