[Protective effect of lytic cocktail (inhibition of stress) on lung injury in severe burn rat].

Objective: To investigate the protective effect of inhibition of stress (lytic cocktail) on lung injury in severe burn rats at early stage.

Methods: Sprague-Dawley rats inflicted with 30% TBSA full-thickness burn were randomly divided into A group (n = 36, fluid resuscitation with administration of lytic cocktail), B group (n = 36, fluid resuscitation only). Lung function was evaluated by partial pressure of oxygen (PaO2) in arterial blood and histopathologic changes on 3, 5, 7, 10 post burn day (PBD).

[Influence of stress inhibition on invasive infection in burn wound during early postburn stage in severely burned rats].

Objective: To investigate the influence of inhibition of stress on the survival rate, organ dysfunction and (Th)1/Th2 cytokine profiles of the rats with invasive infection in the wound at early postburn stage.

Methods: Sprague-Dawley rats inflicted with 30% TBSA full thickness burn were randomly divided into A (n = 36, with immediate resuscitation), B (n = 36, with immediate resuscitation and lytic cocktail administration). After subeschar injection of 0.