Publications by authors named "Ke-fei Dou"
Article Synopsis
- Lipoprotein(a) [Lp(a)] is recognized as a potential predictor for atherosclerotic cardiovascular disease (ASCVD), with a study involving 9944 Chinese patients revealing its association with increased cardiovascular event risk based on current risk stratification guidelines.
- Patients were categorized into very-high-risk (VHR) and non-VHR subgroups, with Lp(a) plasma levels influencing the prevalence of cardiovascular events (CVEs) observed over an average follow-up of 38.5 months.
- The results indicated that higher Lp(a) levels correlate with a significant increase in CVE risk, especially in the VHR subgroup, with adjusted hazard ratios showing a 2.18 times higher risk in the highest Lp
Article Synopsis
- - The study evaluates changes in left ventricular thrombus (LVT) treatment over 12 years among heart failure patients, highlighting a shift towards increased use of oral anticoagulants at discharge from 29.6% in 2009 to 74.0% in 2021.
- - Analyzing 1,675 patients with LVT, results indicated that the overall death rate was 17.3% during an average follow-up of 3.8 years, with significant incidents including cardiovascular death (16.0%) and major adverse cardiac events (19.8%).
- - Patients receiving anticoagulation had a higher prevalence of dilated cardiomyopathy and lower left ventricular ejection fraction (LVEF
Background: Chronic total occlusions (CTO) occur in about 20% of patients referred for coronary angiography, and right coronary artery (RCA) CTO has been reported in 38-50% of the entire CTO population. Limited data on angiographic and procedural characteristics of RCA-CTO and the risk of adverse cardiac events asks for a detailed study.
Methods: From 2010 to 2013, patients with attempted revascularization of at least one CTO lesion were included and followed up to 5 years after PCI.
Objectives: To evaluate the predictive value of fasting plasma glucose (FPG) for in-hospital mortality in patients with acute myocardial infarction (AMI) with different glucose metabolism status.
Methods: We selected 5,308 participants with AMI from the prospective, nationwide, multicenter CAMI registry, of which 2,081 were diabetic and 3,227 were nondiabetic. Patients were divided into high FPG and low FPG groups according to the optimal cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts, respectively.
Article Synopsis
- - The study investigates the clinical significance of new indices, TyAG and TyAG-BMI, which incorporate estimated average glucose into existing measures of insulin resistance (TyG and TyG-BMI) in patients with atherosclerotic cardiovascular disease (ASCVD).
- - Conducted on nearly 10,000 Chinese patients, the study analyzed cardiovascular events over 38.5 months and found that higher values of TyAG and TyAG-BMI correlated with increased cardiovascular risk factors and event rates.
- - Results indicated that TyAG and TyAG-BMI might provide improved risk prediction for cardiovascular events compared to the traditional indices, with TyAG-BMI showing the strongest predictive capability.
Article Synopsis
- - The study investigates how stress-related glycemic indicators (like admission blood glucose, stress-hyperglycemia ratio, and glycemic gap) affect cardiovascular mortality outcomes in patients over 80 years old who experienced acute myocardial infarction (AMI).
- - Researchers analyzed data from 933 elderly patients and found that higher levels of these glycemic indicators were associated with significantly increased risks of both short-term (30 days) and long-term cardiovascular mortality.
- - The results reveal a J-shaped effect for admission blood glucose and a U-shaped effect for the other two indicators, highlighting their importance in assessing the health of older adults following AMI.
Background: The prognostic value of coronary collateral circulation (CC) in patients undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is underdetermined. The purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent PCI.
Methods: We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and December 2013.
Article Synopsis
- * Misunderstandings around diagnosis and management of statin-related issues, including a lack of unified definitions, contribute to insufficient statin use and poor patient adherence.
- * This consensus aims to clarify gene polymorphisms related to statins and propose standardized diagnostic criteria and management strategies to improve their clinical application and treatment of cardiovascular disease in China.
Objectives: To establish a scoring system combining the ACEF score and the quantitative blood flow ratio (QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention (PCI).
Methods: In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263 consecutive cases of CAD patients after PCI in PANDA III trial database.
Background: The recently introduced ultrasonic flow ratio (UFR), is a novel fast computational method to derive fractional flow reserve (FFR) from intravascular ultrasound (IVUS) images. In the present study, we evaluate the diagnostic performance of UFR in patients with intermediate left main (LM) stenosis.
Methods: This is a prospective, single center study enrolling consecutive patients with presence of intermediated LM lesions (diameter stenosis of 30%-80% by visual estimation) underwent IVUS and FFR measurement.
Purpose: It is uncertain whether β-blockers are beneficial for long-term prognosis in older patients following acute myocardial infarction (AMI). Thus, this study sought to examine the effect of β-blockers on long-term cardiovascular mortality (CVM) in the oldest old (≥ 80 years) with AMI.
Methods: In this prospective, consecutive, non-randomized study, a total of 1156 patients with AMI admitted within 24 h after onset of symptoms were enrolled from January 2012 to February 2020.
Article Synopsis
- Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) typically need dual antiplatelet therapy for at least 1 year to reduce the risk of stent thrombosis, which is worsened by uncovered stent struts.
- This study investigates whether early use of a specific cholesterol-lowering treatment (PCSK9 monoclonal antibody) can improve the coverage of stent struts in ACS patients, compared to standard treatment, over 12 weeks.
- The research aims to provide insights that could lead to changes in treatment strategies for ACS patients, particularly the potential combination of intensive lipid-lowering therapy and shortened duration of antiplatelet therapy.
Article Synopsis
- LDL-TG (low-density lipoprotein-triglyceride) is a new lipid marker found to be connected to cardiovascular events (CVEs) in patients with chronic coronary syndrome (CCS) undergoing PCI (percutaneous coronary intervention).
- A study involving 4,415 patients investigated the association of LDL-TG and hs-CRP (high-sensitivity C-reactive protein) levels on the risk of CVEs over 7 years, revealing that higher LDL-TG concentrations correlated with more CVEs, particularly in patients with elevated hs-CRP levels.
- The findings suggest that measuring both LDL-TG and hs-CRP can help predict cardiovascular risks more effectively in patients treated with PCI, especially those with higher
Article Synopsis
- - The study aimed to evaluate how effective sacubitril/valsartan is in lowering blood pressure in diabetes patients with primary hypertension, as well as its impact on glycolipid metabolism compared to olmesartan.
- - In the trial with 124 participants, patients taking sacubitril/valsartan experienced a significantly greater reduction in systolic blood pressure and had a higher percentage meeting their blood pressure target compared to those on olmesartan.
- - While both medications led to improvements in glucose and lipid levels, sacubitril/valsartan did not show any adverse effects and proved to be more effective in achieving blood pressure goals.
[This corrects the article DOI: 10.3389/fendo.2022.
View Article and Find Full Text PDFObjectives: The study aims to investigate the safety and feasibility of retrograde CTO intervention via collateral connection grade 0 (CC-0) septal channel and to identify predictors of collateral tracking failure.
Background: Guidewire crossing a collateral channel is a critical step for successful retrograde percutaneous coronary intervention (PCI) of chronic total occlusion (CTO).
Methods: Retrograde PCI was attempted in 122 cases of CTO with CC-0 septal collaterals from December 2018 to May 2021.
Objectives: To assess the correlation between triglyceride glucose (TyG) index and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI).
Methods: A total of 2190 patients with STEMI who underwent primary angiography within 12 h from symptom onset were selected from the prospective, nationwide, multicenter CAMI registry. TyG index was calculated with the formula: Ln [fasting triglycerides (mmol/L) × fasting glucose (mmol/L)/2].
Background The PRAISE (Prediction of Adverse Events Following an Acute Coronary Syndrome) score is a machine-learning-based model for predicting 1-year all-cause death, myocardial infarction, and Bleeding Academic Research Consortium (BARC) type 3/5 bleeding. Its utility in an unselected Asian population undergoing percutaneous coronary intervention for acute coronary syndrome remains unknown. We aimed to validate the PRAISE score in a real-world Asian population.
View Article and Find Full Text PDFBackground: The focus of this investigation into the impact of type 2 diabetes mellitus (T2DM) on left ventricular thrombus (LVT) is (a) the differences in LVT characteristics, (b) long-term clinical outcomes, and (c) differential effects of direct oral anticoagulants (DOAC) among patients with T2DM and without diabetes.
Methods: Patients with confirmed LVT from 2009 to 2021 were included. The primary endpoints were major adverse cardiac and cerebrovascular events (MACCE), composite of cardiovascular death, ischemic stroke, and acute myocardial infarction (AMI).
Low-density lipoprotein cholesterol (LDL-C) has been considered as the primary target for the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, there are still residual cardiovascular risks in some patients even if LDL-C achieves the target level. Emerging evidence suggestes that elevated triglyceride (TG) level or triglyceride-rich lipoprotein (TRL) cholesterol (TRL-C) is one of the important components of the residual cardiovascular risks.
View Article and Find Full Text PDFBackground: The relationship between remnant cholesterol (RC) and atherosclerotic cardiovascular risk has been given increasing attention in recent years. However, its association with verbal learning and memory performance has not been reported.
Methods: Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 database.
Background and aims: Our goals in the study were to (1) quantify the discordance in LDL-C levels between equations (the Friedewald, Sampson, and Martin/Hopkins equations) and compare them with direct LDL-C (dLDL-C); and (2) explore the proportion of misclassified patients by calculated LDL-C using these three different equations. Methods: A total of 30,349 consecutive patients with angiographically confirmed coronary artery disease (CAD) were prospectively enrolled. Concordance was defined as if the LDL-C was <1.
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