Publications by authors named "Ke-Yin Liu"
Aim: To directly quantify peroxynitrite (ONOO) using a highly sensitive fluorescence resonance energy transfer probe RN-NA, investigate the association between ONOO and primary open angle glaucoma (POAG), and clarify whether RN-NA could be used as a potential tool for POAG diagnosis.
Methods: Plasma and aqueous humor (AH) samples were collected from POAG patients (=100, age: 59.70±6.
Article Synopsis
- Acute myocardial infarction (AMI) is a significant health issue worldwide, and this study explored the effects of Angiotensin IV (Ang IV) on AMI in mice, revealing its potential protective properties.
- The infusion of Ang IV prior to AMI significantly lowered mortality rates, reduced inflammation, decreased cardiomyocyte apoptosis, and improved heart function compared to untreated AMI subjects.
- The research indicated that Ang IV may help mitigate oxidative stress, inflammation, and fibrosis in the heart, suggesting a therapeutic role for Ang IV in the aftermath of an AMI.
A bifunctional sensitive fluorescence probe based on pyrene for the detection of pH and viscosity in lysosome.
Spectrochim Acta A Mol Biomol Spectrosc
January 2022
Lysosome is one of the important organelles in intracellular transport. It plays a significant role in the physiological process. The lysosomal microenvironment affects the functions of lysosome.
View Article and Find Full Text PDFTemporomandibular disorder (TMD) is a complicated and multi‑factorial disease related to inflammation and cartilage destruction. Intra‑articular injection of xanthan gum (XG) has been demonstrated to protect the joint cartilage and reduce osteoarthritis progression. However, the role and mechanism of XG in TMD is still unclear.
View Article and Find Full Text PDFArticle Synopsis
- Sepsis is a major cause of mortality in severe infections globally, and the study explores how remifentanil, a powerful pain relief drug, affects inflammation in human aortic endothelial cells (HAECs) induced by lipopolysaccharide (LPS).
- The research involved pretreating HAECs with remifentanil or a control solution, followed by stimulation with LPS to analyze inflammation, DNA damage, and specific protein expressions related to inflammation.
- Results showed that remifentanil significantly lowered inflammation markers and DNA damage while impacting key signaling pathways, suggesting it could be a beneficial pain management option for patients with sepsis.