Publications by authors named "Ke-Yi Xiao"
Background: While intervertebral disc degeneration (IVDD) is crucial in numerous spinally related illnesses and is common among the elderly, the complete understanding of its pathogenic mechanisms is still an area of ongoing study. In recent years, it has revealed that liposomes are crucial in the initiation and progression of IVDD. However, their intrinsic mediators and related mechanisms remain unclear.
View Article and Find Full Text PDFPCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis.
BMC Musculoskelet Disord
July 2024
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent an effective strategy for reducing cardiovascular disease risk. Yet, PCSK9's impact on osteoporosis remains unclear. Hence, we employed Mendelian randomization (MR) analysis for examining PCSK9 inhibitor effects on osteoporosis.
View Article and Find Full Text PDFBackground: Although intervertebral disc degeneration (IVDD) is a critical factor in many spine-related diseases and has an extremely high prevalence in the aging population, the potential pathogenesis remains to be clarified entirely. Immune cells have been found to perform an essential function during the onset and progression of IVDD in recent years. Therefore, we explored the association between immune cell characteristics and IVDD through Mendelian randomization (MR) analysis and further delved into the mediating role of potential metabolites.
View Article and Find Full Text PDFArticle Synopsis
- Interleukin-6 (IL-6) plays a role in various rheumatologic disorders, and blocking its receptor (IL6R) could be a potential treatment for ankylosing spondylitis (AS), though the effectiveness is still debated.* -
- Using Mendelian randomization (MR) and genome-wide association studies (GWAS), researchers found that IL6R inhibitors significantly decrease the risk of developing AS.* -
- The analyses showed consistent results across different GWAS data without significant variations, supporting the therapeutic potential of targeting IL6R in AS treatment.*
Article Synopsis
- A study was conducted to explore the causal link between type 2 diabetes (T2DM) and intervertebral disc degeneration (IVDD), focusing on how triglycerides (TGs) might play a role.
- Using Mendelian randomization with data from thousands of cases and controls, the research found that T2DM significantly raises the risk for IVDD, while IVDD does not seem to influence T2DM risk.
- It was concluded that TGs account for about 11.4% of T2DM's effect on IVDD, but more research is needed to uncover other factors that might contribute to this relationship.
Objective: Clostridium difficile-associated diarrhea (CDAD) accounts for up to 25% of patients with antibiotic-associated diarrhea (AAD). We aimed to determine which probiotic is most effective in preventing CDAD using a network meta-analysis.
Methods: Studies were identified by searching PubMed, EMBASE and the Cochrane Library databases for randomized controlled trials (RCTs) that evaluated the efficacy of probiotic interventions for CDAD.