Publications by authors named "Ke-Yao Dai"
Article Synopsis
- Two polysaccharides, PGP-90 and PGP-100, were extracted from Peach gum using alkaline electrolyte water and characterized as AG-II arabinogalactans with specific branching structures.
- Animal studies showed that both polysaccharides enhanced immune function, increased lymphocyte proliferation, improved macrophage activity, and altered lymphocyte subpopulations in tumor-bearing mice.
- PGP-90 and PGP-100 also promoted cytokine secretion and reduced tumor growth, with PGP-100 showing greater anti-tumor effects, indicating potential as functional anti-tumor agents.
Article Synopsis
- Six different polysaccharides from Cordyceps militaris were isolated, showing similar chemical properties but varying molecular weights and anti-tumor effects.
- One specific polysaccharide, LMW-CMP, was found to be an α-glucan and effectively inhibited the growth of liver cancer cells (HepG2) by inducing cell death and blocking apoptosis.
- In animal studies, LMW-CMP showed a 45.70% tumor inhibition rate in mice by enhancing immune function and regulating immune cell activity.
An important micronutrient involved in immune response and antitumor is selenium. LMW-GFP, a polysaccharide extracted from Grifola frondosa seed bodies, has a relatively weak antitumor effect on BGC-823 and MFC cells in vitro, whereas selenium binding to LMW-GFP can significantly increase the in vitro antitumor activity of LMW-GFP. In this study, Se-LMW-GFP was prepared by the HNO-NaSeO method, and the structures of LMW-GFP and Se-LMW-GFP were characterized by UV-visible spectroscopy of absorption, FTIR spectroscopy, and electron scanning microscopy, and these structural analyses showed that selenium was successfully complexed to LMW-GFP.
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- Velvet antler, a traditional Chinese medicine, is commonly used in medicinal wine but its leftover residue is often wasted; this study examines the properties of a protein extracted from this residue.
- The extracted velvet antler protein (VA-pro) shows high purity, specific structural characteristics, and notable amino acid content, which may contribute to its biological effects.
- VA-pro demonstrated significant anti-tumor activities in mice, improving body weight, immune function, and inhibiting tumor growth by affecting cell cycle processes, suggesting its potential as an immune booster for cancer patients.
Article Synopsis
- * The optimal extraction conditions identified included ultrasonic power, time, temperature, and liquid/solid ratio, resulting in a glycoprotein yield of 1.63%.
- * The glycoprotein exhibited strong antioxidant properties and enhanced immune functions in mice, suggesting its potential as a functional food ingredient in the food industry.
Article Synopsis
- A new low molecular weight polysaccharide, LMW-BSP, was extracted from Bletilla striata and characterized, revealing it to be a neutral polysaccharide with a molecular weight of 23 kDa, primarily composed of glucose and mannose in a specific ratio.
- Structural analysis techniques, including periodate oxidation, Smith-degradation, and NMR spectroscopy, determined the main chain sequence of LMW-BSP.
- The polysaccharide demonstrated significant antitumor activity in H22 tumor-bearing mice, enhancing immune cell function and leading to the death of cancer cells, suggesting its potential as a treatment component for hepatocellular carcinoma.
In the present study, the low molecular weight of chitosan (CS) was prepared and its activity on thymopentin-activated mice bearing H22 solid tumors was further researched. The purity and molecular weight of CS were determined by UV and HPGPC spectra, and its immunosuppressive effects on H22 tumor-bearing mice were evaluated through determination on immune organs, cells and cytokines. Results showed that CS contained little impurities with the average molecular weight of 1.
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