Publications by authors named "Ke-Xin Lin"
Article Synopsis
- Radiotherapy peer review is essential for ensuring quality in treatment planning, though its effects have been unclear.
- A systematic review and meta-analysis of 55 studies found that peer review led to change recommendations in 28% of cases, with 12% being major changes requiring significant adjustments.
- The most common issues prompting changes included target volume delineation and dose prescriptions, suggesting that implementing early peer review could enhance patient safety across all treatment methods.
Article Synopsis
- Quality improvement (QI) efforts are essential in addressing healthcare disparities and promoting health equity, particularly through equity-focused QI (EF-QI) interventions tailored to the needs of marginalized groups.
- A scoping review analyzed 5,330 titles, ultimately identifying 36 relevant articles that highlighted various barriers faced by EF-QI interventions, including provider and institutional challenges, with a significant focus on racialized communities.
- Engaging patient partners and hospital leadership in the design process is crucial, as sustainability emerges as a significant theme affecting the effectiveness and future of EF-QI interventions.
PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies.
Cancer Immunol Immunother
December 2023
Article Synopsis
- Colorectal cancer (CRC) is a leading cause of cancer deaths, with a majority being proficient in mismatch repair (pMMR) and microsatellite stable (MSS), which show little response to PD-1/PD-L1 immune checkpoint inhibitors (ICIs).
- Current research is exploring combination treatments, such as dual ICIs and various therapies (chemotherapy, radiotherapy, and others), to enhance the effectiveness of PD-L1/PD-1 inhibitors in MSS CRC patients.
- The paper aims to examine the causes of resistance to PD-1/PD-L1 ICIs in pMMR/MSS CRC, review existing combination therapy results, and suggest future research directions.
Article Synopsis
- Hypoxic-ischemic encephalopathy is a serious condition in newborns with high rates of morbidity and limited treatment options, leading researchers to study it in neonatal rats.
- The study used a specific rat model to compare effects of hypoxic-ischemic reperfusion brain injury versus simple hypoxic-ischemic brain injury, revealing that mitochondrial proteins and signs of ferroptosis were prevalent in the reperfusion model.
- Results indicated that reperfusion worsens brain injury while also triggering protective responses related to ferroptosis, suggesting new directions for treatment and understanding of the condition in neonates.
Article Synopsis
- Two types of lightweight porous concrete were developed: expanded polystyrene concrete (EPSC) and ceramics-cement based porous material (CCPM), both derived from C60 concrete.
- Dynamic mechanical experiments were conducted using a 100 mm split Hopkinson pressure bar (SHPB) to analyze the strength, deformation, and impact properties of these materials under varying strain rates.
- Results indicate that both materials exhibit strain rate sensitivity, with CCPM outperforming EPSC in strength and toughness, suggesting better potential for use in civil defense applications.