Publications by authors named "Ke-Xin Gan"
Article Synopsis
- Sotos syndrome is an autosomal dominant disorder characterized by accelerated growth and precocious puberty, while ADHD is a common neurodevelopmental condition.
- A pediatric case study revealed a girl with Sotos syndrome who also developed ADHD, highlighting the need for careful monitoring of children with this genetic disorder.
- Genetic analysis identified a potentially pathogenic mutation linked to Sotos syndrome, emphasizing the importance of recognizing potential comorbidity with ADHD to prevent missed diagnoses.
Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats.
World J Gastroenterol
March 2013
Aim: To investigate the effects of mitofusin-2 (MFN2) on insulin sensitivity and its potential targets in the liver of rats fed with a high-fat diet (HFD).
Methods: Rats were fed with a control or HFD for 4 or 8 wk, and were then infected with a control or an MFN2 expressing adenovirus once a week for 3 wk starting from the 9(th) wk. Blood glucose (BG), plasma insulin and insulin sensitivity of rats were determined at end of the 4(th) and 8(th) wk, and after treatment with different amounts of MFN2 expressing adenovirus (10(8), 10(9) or 10(10) vp/kg body weight).