Publications by authors named "Ke-Qi Liu"
Article Synopsis
- The study explores the relationship between circulating vitamin D levels and various clinical traits using a method called Mendelian randomization to account for confounding factors.
- Results indicate that lower genetically determined vitamin D is associated with decreased bone mineral density, higher total cholesterol, and triglyceride levels, while positively linked to lymphocyte counts.
- The research concludes that while vitamin D affects certain metabolic markers, it does not show a direct causal connection to clinical diseases.
Background: Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.
Methods: We performed multivariable regression analyses to assess the association of birth weight with bone parameters measured by dual-energy X-ray absorptiometry (DXA) and by quantitative ultrasound (QUS), independently. We also implemented a systemic Mendelian randomization (MR) analysis to explore the causal association between them with both fetal-specific and maternal-specific instrumental variables.
To infer the causality between obesity and fracture and the difference between general and abdominal obesity, a prospective study was performed in 456,921 participants, and 10,142 participants developed an incident fracture with follow-up period of 7.96 years. A U-shape relationship was observed between BMI and fracture, with the lowest risk of fracture in overweight participants.
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- The Westlake BioBank for Chinese (WBBC) pilot project includes 4,535 whole-genome sequences and 5,841 high-density genotyping samples, identifying over 81 million genetic variants.
- A population-specific reference panel and an online server have been created to enhance genetic analysis in the Chinese population, particularly for rare variants.
- The study highlights genetic selection in specific genes, as well as historical allelic variations related to alcohol metabolism, while also demonstrating genetic differences between North Han and South Han populations along geographical boundaries.
We combined conventional evidence from longitudinal data in UK Biobank and genetic evidence from Mendelian randomization (MR) approach to infer the causality between sleep behaviors and fracture risk. We found that participants with insomnia showed 6.4% higher risk of fracture (hazard ratio [HR] = 1.
View Article and Find Full Text PDFPurpose: The Westlake BioBank for Chinese (WBBC) pilot cohort is a population-based prospective study with its major purpose to better understand the effect of genetic and environmental factors on growth and development from adolescents to adults.
Participants: A total of 14 726 participants (4751 males and 9975 females) aged 14-25 years were recruited and the baseline survey was carried out from 2017 to 2019. The pilot cohort contains rich range of information regarding of demographics and anthropometric measurements, lifestyle and sleep patterns, clinical and health outcomes.
Objectives And Methods: With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). The eBMD was derived from heel ultrasound measurement.
View Article and Find Full Text PDFBackground: CD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent.
Materials And Methods: Twenty-six articles involving thirty-seven datasets were recruited to evaluate the association between rs2569190 (9413 patients and 7337 controls), C-159T (4813 patients and 2852 controls) polymorphisms and cardiovascular diseases in a meta-analysis.