Publications by authors named "Ke-Meng Xiang"
Article Synopsis
- Lei's formula (LSF) is a traditional Chinese herbal remedy that shows potential in treating osteoarthritis (OA) by protecting cartilage and reducing degeneration.
- The study focuses on how LSF works by inhibiting the mTOR signaling pathway, which is linked to chondrocyte senescence, a key factor in OA progression.
- Results indicate that LSF effectively preserves cartilage health by decreasing harmful markers, promoting beneficial markers, and ultimately reducing cartilage degradation through its action on chondrocyte behavior.
Background: Knee osteoarthritis (KOA) often causes joint pain, weakness and mobility disorders, which seriously affects people's daily life and makes them unable to work and study normally. Traditional Chinese medicine (TCM) prescription Danggui Sini Decoction (DGSND) has been widely used in clinical practice and achieved good results. But there is no high-level evidence to support this result.
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