Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice.

Background: Environmental enrichment (EE) has been shown to enhance cognitive function in mouse models of Alzheimer's disease (AD). Magnesium-L-threonate (MgT) is a compound with a newly discovered effect to rescue learning and memory function in aging and AD mice.

Aim: To study the additive therapeutic effect of EE combined with MgT (EM) and the potential mechanism underlying the effects.

A three dimensional porous metal-organic framework [Fe4L6.(DMF)3.(H2O)10] constructed from neutral discrete Fe4L6 pyramids [H2L = 1,3-benzodihydroxamix acid].

A 3-D porous zeolite-like metal-organic framework surviving guest removal is assembled from a well-defined tetrahedral Fe(4)L(6) cavity by the cooperativity of hydrogen bonds and [small pi]-[small pi] stacking.

Generation of an equilibrating collection of crystalline solids from a dynamic combinational library.

Thermodynamically controlled crystallization of a copper-containing building block [CuL] (H(2)L = 2-(2'-hydroxyphenyl)-Delta(2)-thiazoline-4-carboxylic acid) from a methanol-ethanol mixture solvent leads to a combinatorial mixture of four crystalline solids, from which each of them is isolated and structurally characterized.

Design and crystal structures of triple helicates with crystallographic idealized D3 symmetry: the role of side chain effect on crystal packing.

Novel crystallographic D3-symmetric binuclear triple molecular helices [Co2L(1)3][BF4]4 (1), [Zn2L(1)3][BF4]4 (2), [Mn2L(1)3][BF4]4 (3), [Co2L(2)3][BF4]4 (4), [Zn2L(2)3][BF4]4 (5), and [Mn2L(2)3][BF4]4 (6) have been achieved to establish the side chain effect on molecular packing, where L1 is [(C5H4N)C(CH3)=N-(C6H4)-]2CH2 and L2 is [(C5H4N)C(CH3)=N-(C6H4)-]2O, respectively. Crystal structure analyses show that each helix crystallizes in a hexagonal crystal system with space group Pc1 and the general axis of the helix occupies the crystallographic 3-fold axial position with the other three crystallographic 2-fold symmetries perpendicular to it. Each metal center is bound to three pyridylimine units to attain C3 pseudooctahedral coordination geometry with respective equivalent metal-N (CH=N) and metal-N (pyridyl) bonds.

Novel ferrocene-containing helical triangular macrocycle achieved via an exchange reaction.

A novel ferrocene-containing helical triangular macrocyclic compound has been constructed through an exchange reaction of hydrazone groups which templated and catalyzed by Co(II) ions.