Publications by authors named "Ke-Jie He"
Background: Colorectal cancer is one of the most prevalent and deadly cancer types worldwide. Emerging evidence suggests that high body mass index (BMI) is a significant risk factor for colorectal cancer, particularly among the older adult population. This comprehensive analysis aims to explore the complex epidemiological patterns of colorectal cancer, with a focus on the association between high BMI and disease burden in the older adult.
View Article and Find Full Text PDFBackground: Tracheal, bronchus, and lung (TBL) cancer attributable to ambient particulate matter pollution (APMP) is a growing global health concern, particularly in individuals aged 70 and above. This study aims to evaluate past trends, identify key drivers, and project future disease burden.
Methods: Data from the Global Burden of Disease Study 2021 was analyzed for TBL cancer-related disability-adjusted life years (DALYs) and mortality from 1990 to 2021, stratified by SDI regions.
Background: We aimed to assess temporal trends in type 2 diabetes mellitus (T2DM)-related deaths and disability-adjusted life years (DALYs) at global and cross-social demographic index (SDI) levels, using data from the Global Burden of Disease (GBD) in 2021.
Methods: We used geospatial mapping to visualize the global distribution of T2DM-related mortality and DALYs in 2021. Joinpoint regression assessed annual and average percent changes in DALYs and deaths from 1990 to 2021 across SDI regions.
Article Synopsis
- - The study investigates how aging impacts gastric cancer (GC) prognosis by examining the relationship between senescence, lysosomes, and GC outcomes, utilizing data from The Cancer Genome Atlas (TCGA).
- - Researchers identified two distinct subtypes of GC, revealing that one subtype (Cluster 2) has a poorer survival rate, and developed a risk prediction model based on the presence of lysosomes and senescence markers.
- - The findings include insights into immune system interactions and the protective role of the MMP12 gene in GC cells, highlighting potential therapeutic targets and the importance of molecular features in predicting patient outcomes.
Background: Unhealthy diets significantly contribute to stomach, colorectal and esophageal cancer burden globally. Western diets high in processed and red meats promote carcinogenesis in these gastrointestinal cancers. However, adolescent and young adult (AYA) patients' unique needs regarding these cancers have been neglected.
View Article and Find Full Text PDFBackground And Aims: There is an association between cancer and increased ribosome biogenesis. At present, the RPL7L1 (60S Ribosomal Protein L7-Like 1) were less reported by literature search. Study reports that RPL7L1 is associated with mouse embryonic and skeletal muscle.
View Article and Find Full Text PDFBackground: Liver cancer is a leading cause of cancer-related deaths worldwide. Lysosomal dysfunction is implicated in cancer progression; however, prognostic prediction models based on lysosome-related genes (LRGs) are lacking in liver cancer. This study aimed to establish an LRG-based model to improve prognosis prediction and explore potential therapeutic targets in liver cancer.
View Article and Find Full Text PDFTICRR is a regulatory factor of DNA replication with ToPBP1 interaction. At present, the underlying function and mechanisms of TICRR remain unclear in LIHC. Our objective was to assess the function and prognosis of TICRR in LIHC.
View Article and Find Full Text PDFArticle Synopsis
- Inflammatory bowel disease (IBD) is becoming increasingly common worldwide, creating a need for effective treatments, and glycerol monolaurate (GML) shows promise due to its antibacterial and anti-inflammatory properties.
- In a study, mice with DSS-induced colitis treated with GML showed improvement in symptoms, decreased expression of pro-inflammatory factors, and enhanced expression of anti-inflammatory factors, indicating a reduction in inflammation.
- GML treatment was linked to the inhibition of specific signaling pathways and improved gut health by altering the abundance of beneficial gut bacteria, suggesting a potential therapeutic role for GML in managing IBD.
Background: Chronic non-specific low back pain (CNLBP) is a common complaint about medical care and carries a heavy social burden. The efficacy of Tuina (TN) or physiotherapy (PT) for CNLBP has been evaluated in previous systematic reviews. However, there is no high-quality evidence to support the efficacy of Tuina.
View Article and Find Full Text PDFObjective: To observe the therapeutic effect of acupuncture on cancer-related fatigue (CRF) and to explore its possible mechanism.
Methods: A total of 80 patients with CRF were randomized into an observation group and a control group, and finally 67 patients completed the trial (36 patients in the observation group, 31 patients in the control group). Patients in the control group were treated with conventional chemoradiotherapy and symptomatic treatment, while no particular anti-fatigue intervention was adopted.