Publications by authors named "Ke-Huan Sun"
Article Synopsis
- The biosynthesis of berberine alkaloids starts with demethylation of berberine, but past efforts to synthesize them faced issues like low yields and toxic reagents.
- Recent research improved the synthesis method for compounds like demethyleneberberine (DMB), columbamine, and palmatine, making the process more efficient.
- DMB was found to inhibit monoamine oxidase B (MAO-B), an enzyme linked to Parkinson's disease, suggesting potential therapeutic benefits of berberine alkaloids, especially DMB.
Objective: To investigate the antidepressant-like effects of Chaihu Shugan Powder (CSP, ) and to explore its underlying mechanisms.
Methods: Thirty-two Sprague-Dawley rats were randomly divided into control (CON), chronic unpredictable mild stress (CUMS), fluoxetine (FLU), and CSP groups, 8 rats in each group. All of the rats except for those in the control group were subjected to 3 consecutive weeks of CUMS to establish the depression model.
Objective: To study the effect of Tiantai No. 1 [symbol in text] on gene expression profile in hippocampus of Alzheimer's disease (AD) rat, molecular genetic target points of the effect of this drug were defined, its molecular genetic pharmacodynamic mechanism of anti-AD was further explored at molecular gene level, and a scientific basis was provided for its clinical availability and promotion.
Methods: Thirty male Sprague-Dawley rats were divided into three groups with 10 rats per group: sham-operation group, model group and Tiantai No.
[Chemical constituents and their antitumor cytotoxic activity in leaves of Ilex centrochinensis].
Zhongguo Zhong Yao Za Zhi
February 2013
Objective: To investigate the chemical constituents in leaves of Ilex centrochinensis and their antitumor bioactivity.
Method: Various chromatography techniques such as column chromatography on silica gel, Sephadex LH-20 and preparative HPLC were used to isolate and purify the compounds and their structures were identified by spectral data and physicochemical properties. Their antitumor effect was tested by MTT method.