Publications by authors named "Ke-Fang Sun"
Unlabelled: To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM.
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- This study investigates how variations in the CYP3A4 gene affect the levels and effectiveness of the epilepsy drug perampanel (PER) in Chinese children with epilepsy.
- 102 pediatric patients were analyzed after maintaining consistent PER doses for 21 days, measuring drug concentrations and assessing seizure reduction rates.
- The results indicate significant differences in drug concentrations based on genetic variations, with implications for both treatment efficacy and adverse effects, suggesting that CYP3A4 genetic profiles should be considered in prescribing PER.
Purpose: This study was the first to evaluate the effect of CYP3A5*3 gene polymorphisms on plasma concentration of perampanel (PER) in Chinese pediatric patients with epilepsy.
Methods: We enrolled 98 patients for this investigation. Plasma PER concentrations were measured using liquid chromatography-tandem mass spectrometry.
Objective: To clone heavy-chain and light-chain variable region (VH and VL) gene of mouse-anti-human CD71 monoclonal antibody (mAb).
Method: One-step method was used to extract total RNA, and a set of oligonucleotide primers were designed to amplify the cDNAs with reverse transcriptase-polymerase chain reaction (RT-PCR), and the resultant products were respectively cloned into PMD18-T vector and their sequences analyzed.
Results: The PCR product obtained with the oligonucleotide primers for the variable region of mouse immunoglobulin heavy chain was about 350 bp and that with oligonucleotide primers for the light chain was about 320 bp, and their DNA sequences were determined.