Tooth loss trajectories and their association with all-cause mortality among older Chinese adults.

Background: The association between tooth loss trajectories and all-cause mortality has not been sufficiently explored. This study aims to examine the relationship between tooth loss trajectories and all-cause mortality in Chinese adults aged 65 years and older.

Methods: This study included 3,726 participants from the Chinese Longitudinal Healthy Longevity Study (CLHLS).

Long term gait postural characteristics of children with general foot pain using smartphone connected wearable sensors.

Whether children's general foot pain related to specific foot posture remains unknown. The aim of the study was to determine long-term dynamic foot posture characteristics in children with general foot pain using smartphone-connected wearable sensors. Over a 30-day period, 94 children (37 girls and 57 boys, mean age 9.

Xiexin Tang restores gut barrier function by regulating the differentiation of CD4 T cells via GPRs and HDACs in T2DM rats.

This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPRs while suppressing the expression of HDACs in colon epithelial cells, then significantly elevate the levels of TGF-β1 and IL-18 to regulate the differentiation of T cells and further maintain the intestinal immune homeostasis. Meanwhile, it could markedly inhibit the inflammatory signaling pathway to improve intestinal barrier function, relieving type 2 diabetes mellitus.

Albiflorin improves osteoporotic bone regeneration by promoting osteogenesis-angiogenesis coupling of bone marrow mesenchymal stem cells.

Albiflorin (ALB) has been shown to promote osteogenesis, however, its effect on angiogenesis still remains unclear. This research aimed to explore the effect of ALB on angiogenesis and bone regeneration under osteoporotic conditions. The pro-osteogenesis capacity of ALB was assessed by osteogenic differentiation assays.

Sarcopenia, Depressive Symptoms, and Fall Risk: Insights from a National Cohort Study in the Chinese Population.

Background: Previous investigations have indicated that both sarcopenia and depressive symptoms are linked to a heightened risk of falls. However, the potential synergistic effect of these conditions on fall risk remains unclear. This study aims to assess the combined influence of sarcopenia and depressive symptoms on the occurrence of falls in the Chinese population.

Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models.

Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing a significant clinical challenge. Nanoenzymes like cerium oxide (CeO) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but their delivery efficiency and biological activity require optimization. This study aims to develop a targeted nanozyme delivery system for MIRI treatment by integrating CeO with mesoporous polydopamine (mPDA) and dexrazoxane (DXZ) to achieve synergistic therapeutic effects.

Influence of two sorghum varieties on metabolic factors, microbial community, and flavor component precursors of strong-flavor Baijiu Zaopei.

As the primary raw material for Baijiu brewing, sorghum variety exerts an intricate influence on the taste profile of strong-flavor Baijiu. However, how sorghum variety comprehensively affects Baijiu flavor formation through fermentation by microorganisms and metabolites remains largely unknown. Using 16S&ITS rRNA gene sequencing and non-targeted metabolomics, in this study we comprehensively analyzed the changes in microbial communities and metabolites during fermentation of a glutinous and non-glutinous sorghum variety.

Effects of ultrasonic treatment on the physicochemical, structural, and functional properties of soluble dietary fiber from coffee peels.

Coffee peel (CP) is an important by-product of coffee processing which is rich in bioactive components. In the present work, we extracted coffee peel soluble dietary fiber (CSDF) via ultrasound-assisted alcohol precipitation to reduce resource waste as well as environmental pollution and evaluate its structure, monosaccharide composition, and functional and physicochemical characters. Based on our findings, ultrasonic treatment decreased particle size of CSDF from 131.

Pathogenesis of Focal Segmental Glomerulosclerosis and Related Disorders.

Focal segmental glomerulosclerosis (FSGS) is the morphologic manifestation of a spectrum of kidney diseases that primarily impact podocytes, cells that create the filtration barrier of the glomerulus. As its name implies, only parts of the kidney and glomeruli are affected, and only a portion of the affected glomerulus may be sclerosed. Although the diagnosis is based primarily on microscopic features, patient stratification relies on clinical data such as proteinuria and etiological criteria.

Association of Sleep Duration and Daytime Napping With Risk of Hyperuricemia: A Systematic Review and Meta-Analysis.

Background: Hyperuricemia (HUA), marked by elevated serum urate levels, is increasingly prevalent worldwide. The relationship between lifestyle factors such as sleep duration, daytime napping, and HUA risk remains unclear. Although some studies suggest that sleep variables, including short or long sleep durations and napping, may influence serum uric acid levels, results are inconsistent.

Systemic inflammatory response index improves prognostic predictive value in intensive care unit patients with sepsis.

Sepsis is a severe infectious disease with high mortality. However, the indicators used to evaluate its severity and prognosis are relatively complicated. The systemic inflammatory response index (SIRI), a new inflammatory indicator, has shown good predictive value in chronic infection, stroke, and cancer.

Effects of non-pharmacological interventions on depressive and anxiety symptoms in pregnant women: a systematic review and network meta-analysis.

Background: Given the distinctive physiological characteristics of pregnant women, non-pharmacological therapies are increasingly being used to improve depressive and anxiety symptoms. Our objective was to explore and compare the impact of various non-pharmacological interventions in improving depressive and anxiety symptoms, and to identify the most effective strategies for pregnant women with depressive and/or anxiety symptoms.

Methods: We conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials (RCTs) that compared non-pharmacological interventions to usual care, from the inception of each database up to October 5, 2024.

New Posttranslational Modification Lactylation Brings New Inspiration for the Treatment of Rheumatoid Arthritis.

Lactic acid (LA) is an essential glycolytic metabolite and energy source in the body, which is present in high levels in the synovial fluid of patients with rheumatoid arthritis (RA) and is a reliable indicator for identifying inflammatory arthritis. LA not only acts as an inflammatory amplifier in RA, recent studies have found that novel posttranslational modification (PTM) lactylation mediated by LA may also play a key role in RA. Single-cell sequencing showed that the RA lactylation score of patients with RA was significantly increased, and core lactylation-promoting genes, including NDUFB3, NGLY1, and other genes, were found to be potential biomarkers of RA.

Exploration and validation of a novel reactive oxygen species-related signature for predicting the prognosis and chemotherapy response of patients with bladder cancer.

Background: Reactive Oxygen Species (ROS), a hallmark of cancer, is related to prognosis, tumor progression, and treatment response. Nevertheless, the correlation of ROS-based molecular signature with clinical outcome and immune cell infiltration has not been thoroughly studied in bladder cancer (BLCA). Accordingly, we aimed to thoroughly examine the role and prognostic value of ROS-related genes in BLCA.

Association Between Cognitive Frailty and Depression: A Prospective Cohort Study of Adults Aged 45 Years and Older in China.

Background: The interplay between cognitive frailty and depression remains inadequately understood, with a paucity of evidence from prospective cohort studies. Our study aims to elucidate the relationship between cognitive frailty and the risk of incident depression.

Methods: Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011, 2013, and 2015, subjects were classified according to cognitive frailty criteria established by an international consensus panel.

Comparison of the inverted internal limiting membrane flap technique without versus with an autologous blood clot for treating macular hole-associated retinal detachment.

Background: To investigate the anatomical and functional outcomes of macular hole-associated retinal detachment (MHRD) after vitrectomy using the inverted internal limiting membrane (ILM) flap technique with autologous blood clot (ABC).

Methods: This retrospective observational study included 80 eyes with MHRD that underwent vitrectomy with ILM flap without (46 eyes) or with ABC (34 eyes). Fundus photography and optical coherence tomography were evaluated.

Relationship between serum carotenoids and telomere length in overweight or obese individuals.

Background: Previous researches have demonstrated an association between carotenoids and elongated telomeres. Nonetheless, there is scant scientific evidence examining this relationship in individuals who are overweight or obese, a demographic more predisposed to accelerated aging. This study aims to elucidate the correlation between serum carotenoid concentrations and telomere length within this population group.

Controllable Synthesis of High-Quality Magnetic Topological Insulator MnBiTe and MnBiTe Multilayers by Chemical Vapor Deposition.

With a nontrivial topological band and intrinsic magnetic order, two-dimensional (2D) MnBiTe-family materials exhibit great promise for exploring exotic quantum phenomena and potential applications. However, the synthesis of 2D MnBiTe-family materials via chemical vapor deposition (CVD), which is essential for advancing device applications, still remains a significant challenge since it is difficult to control the reactions among multi-precursors and form pure phases. Here, we report a controllable synthesis of high-quality magnetic topological insulator MnBiTe and MnBiTe multilayers via an evaporation-rate-controlled CVD approach.

Targeted delivery of Saikosaponin A and doxorubicin via hyaluronic acid-modified ZIF-8 nanoparticles for TNBC treatment: Inhibiting metastasis and reducing cardiotoxicity.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of estrogen receptors, progesterone receptors, and HER2 expression, making traditional hormone and targeted therapies ineffective. Chemotherapy remains the primary treatment for TNBC; however, it has failed to adequately address the high rates of recurrence and metastasis, underscoring the urgent need for new therapeutic strategies. This study investigates Saikosaponin A (SSA), a compound extracted from traditional Chinese medicine, for its potential to enhance the efficacy of doxorubicin (DOX) chemotherapy while reducing TNBC metastasis and mitigating DOX-induced cardiotoxicity.

Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: From drug discovery to drug delivery.

Pyroptosis is a critical pathological mechanism implicated in myocardial damage following myocardial infarction (MI), and the crosstalk between macrophages and pyroptotic cardiomyocytes presents a formidable challenge for anti-pyroptosis therapies of MI. However, as single-target pyroptosis inhibitors frequently fail to address this crosstalk, the efficacy of anti-pyroptosis treatment post-MI remains inadequate. Therefore, the exploration of more potent anti-pyroptosis approaches is imperative for improving outcomes in MI treatment, particularly in addressing the crosstalk between macrophages and pyroptotic cardiomyocytes.

Biomarkers of Prothrombotic State and Risk Assessment of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease.

Background: Epidemiologic studies have shown that patients with acute exacerbation of COPD (AECOPD) suffer from morbidity and mortality from venous thromboembolism (VTE) and poor diagnosis. Von Willebrand factor (vWF) and plasminogen activator inhibitor type-1 (PAI-1) are frequently investigated in COPD as crucial parameters for coagulation and fibrinolysis. Nevertheless, the role of vWF and PAI-1 in AECOPD needs further exploration.

Non targeted and targeted LC-MS/MS insights into the composition and concentration of atmospheric microplastics and additives: Impacts and regional changes of sandstorms in Shanghai and Hohhot, China.

Increasing dust storms impact ecosystems and human health by resuspending dust and microplastics. Plastic pollution is a major global concern. This study examines the molecular composition and concentration of atmospheric microplastics and additives in Hohhot and Shanghai, China during dust and non-dust days using non-target and target LC-MS/MS analysis with Multiple Reaction Monitoring (MRM) methodology and a self-established plastic monomers database.