Publications by authors named "Ke Zhangyan"
Objective: To investigate the application value of computed tomography (CT) value (HU) in the diagnosis and differential diagnosis of pulmonary cryptococcosis (PC) and to construct a prediction model.
Methods: Retrospective analysis of the clinical data of 73 patients who presented with nodular/mass-type occupations on lung CT and confirmed by histopathology in our hospital from January 2019 to May 2022 were divided into PC group (23 patients) and non-PC group (50 patients) according to the pathological findings, and the CT values of each patient's lung lesions were measured. The differences in age, gender, symptoms, lesion involvement in one/both lungs, lung lobe distribution, number of lesions, maximum lesion diameter (cm), lesion margin condition, and CT value results were compared between the two groups.
The presence of bone metastases (BM) in patients with lung cancer is indicative of a worse prognosis. The present study aims to investigate the risk factors associated with BM in patients with lung cancer. Patients with lung cancer admitted to the First Affiliated Hospital of Anhui Medical University between June 2019 and September 2021 were enrolled in this study.
View Article and Find Full Text PDFBackground: With the development and wide application of next-generation sequencing (NGS), multiple-gene mutations related to lung cancer are detected using this technology. Notably, even multigene concomitant mutations (co-mutations), which occur at a relatively low incidence, can be detected more effectively using NGS. It is well-known that the percentages of non-small cell lung cancer (NSCLC) in the elderly lung cancer population are also gradually increasing, while its prognosis is hard and the quality of long-term survival is poor.
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- 517 NSCLC patients were analyzed for multiple gene mutations, revealing significant differences in D-dimer levels and other factors across different mutation groups (wild-type, single, and concomitant).
- D-dimer was identified as a risk factor for concomitant mutations and showed high predictive accuracy, with patients in the concomitant mutation group having shorter progression-free survival compared to those with single mutations.
Article Synopsis
- Recent research has evaluated the effectiveness of Raman spectroscopy in diagnosing various tumors, but its specific performance for lung cancer remains uncertain.
- A meta-analysis of 14 studies involving 779 patients showed that Raman spectroscopy has a high sensitivity (92%) and specificity (94%) for detecting lung cancer.
- The findings suggest Raman spectroscopy is a promising diagnostic tool, but further large-scale studies are necessary to validate its use, particularly for real-time detection during procedures like bronchoscopy.
To date, >650 E3 ubiquitin ligases have been described in humans, including >600 really interesting new genes (RINGs), 28 homologous to E6-associated protein C-terminus (HECTs) and several RING-in-between-RINGs. They are considered key regulators and therapeutic targets of many types of human cancers, including gastric cancer (GC). Among them, some RING and HECT E3 ligases are closely related to the proliferation, infiltration and prognosis of GC.
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- - A meta-analysis evaluated the impact of perioperative immunonutrition on postoperative complications in esophageal cancer patients undergoing esophagectomy, reviewing data from seven high-quality randomized controlled trials.
- - The study found no significant differences in the rates of various postoperative infection complications between patients receiving immunonutrition and those on standard nutrition, including pneumonia, wound infections, and urinary tract infections.
- - The results also indicated no statistically significant difference in anastomotic leakage rates, leading to the conclusion that immunonutrition did not provide additional benefits, suggesting a need for larger trials to further explore these effects.
Article Synopsis
- The study discusses acute fibrinous and organizing pneumonia (AFOP), a condition described in 2002, with no established standard treatment, and highlights the controversies surrounding the use of steroids and immunosuppressive drugs due to side effects in older patients.
- An 81-year-old female patient with persistent cough and breathlessness was diagnosed with AFOP after ineffective treatment with antibiotics and antifungals, leading to a lung biopsy that confirmed the disease.
- The patient was effectively treated with steroid monotherapy, achieving complete remission without significant complications, suggesting that steroids could be a reliable treatment option for AFOP in older adults.
The effect of adjuvant chemotherapy in resectable cholangiocarcinoma: A meta-analysis and systematic review.
Hepatobiliary Pancreat Dis Int
April 2019
Background: The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack of randomized control studies. This study aimed to investigate the possible benefit of postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.
Data Sources: Relevant research articles published before 1st March 2018 in PubMed, Embase and the Cochrane library databases were retrieved.