N,N' bis-(2-mercaptoethyl) isophthalamide induces developmental delay in by promoting DAF-16 nuclear localization.

N,N' bis-(2-mercaptoethyl) isophthalamide (NBMI) is a lipophilic thiol-containing agent that has high affinity for toxic metal ions, such as Hg, Pb, and Cd. Studies have shown that NBMI is a potent chelator of heavy metals, yet its potential toxicity in animals has yet to be determined. Using the model organism (), we show no significant change in worms' death rate or lifespan following NBMI treatment (10-1000 μM).

Biphasic ceramic biomaterials with tunable spatiotemporal evolution for highly efficient alveolar bone repair.

Alveolar bone defects, which are characterized by a relatively narrow space and location adjacent to the cementum, require promising substitute biomaterials for their regeneration. In this study, we introduced novel yolk-shell biphasic bio-ceramic granules with/without a customized porous shell and evaluated their biological effect together with structural transformation. Firstly, a self-made coaxial bilayer capillary system was applied for the fabrication of granules.

The Role of Human LRRK2 in Methylmercury-Induced Inhibition of Microvesicle Formation of Cephalic Neurons in Caenorhabditis elegans.

In a previous study, we have shown that methylmercury (MeHg) exposure causes focal aggregation of intracellular transgenic mCherry protein in dendrites of cephalic (CEP) neurons in Caenorhabditis elegans (C. elegans). However, the underlying mechanism is unknown.

Co-transplantation of bone marrow mesenchymal stem cells and monocytes in the brain stem to repair the facial nerve axotomy.

After the facial nerve axotomy (FNA), the distal end of the axon would gradually decay and disappear. Accumulated evidence shows that transplantation of bone marrow mesenchymal stem cells (BMSCs) reveals potential in the treatment of nervous system diseases or injuries. This study is aimed at investigating the therapeutic effects of co-transplantation of BMSCs and monocytes in FNA.

Long-term Oncologic Outcomes of Laparoscopic Anterior Resections for Cancer with Natural Orifice Versus Conventional Specimen Extraction: A Case-Control Study.

Background: Although the short-term advantages of natural orifice specimen extraction are widely recognized, controversy exists concerning oncologic safety after laparoscopic surgery for colorectal cancer.

Objective: This study aimed to investigate the impact of natural orifice specimen extraction on local recurrence and long-term survival of patients undergoing colorectal cancer surgery.

Design: This is a propensity score-matched comparative study.

Minimally invasive complete mesocolic excision and central vascular ligation (CME/CVL) for right colon cancer.

Total mesorectal excision (TME) is the standard of care in rectal cancer surgery. Complete mesocolic excision and central vascular ligation (CME and CVL) are surgical concepts that are extrapolated from the principles of TME. Increasingly adopted by surgical units worldwide, laparoscopic CME/CVL for right sided colon cancer is a challenging procedure that requires meticulous dissection by the surgeon and detailed knowledge of the colonic vascular anatomy.

Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9.

Osteoarthritis (OA) is a whole-joint disease with extremely high prevalence. In all treatment approaches of OA, blocking the degradation of the cartilage extracellular matrix is an important treatment. In OA, overexpression of derivative enzymes leads to excessive catabolism and reduced synthesis of cartilage including type II collagen and aggrecan, which results in irreversible destruction of the joint.

Sex differences in high-level appreciation of automobile design-evoked gamma broadband synchronization.

The present study was conducted to provide neuroimaging correlates for neurodesign of automobile for marketing aesthetics, using event-related spectral perturbations (ERSPs) and participant reports. Thirty men and women aged 22-27 years were presented with various 3-dimensional automobile modelling shapes (rectangular, streamlined, and round), which were cross-matched with various interior colour tones (pure hue/vivid, light, and dark tones) in the experimental conditions, i.e.

Dispersibility and Photochemical Stability of Delaminated MXene Flakes in Water.

The environmental stability of 2D MXene flakes must be systematically studied before their further application. Herein, the colloidal dispersibility and photochemical stability of delaminated Ti C T MXene flakes modified with hydrazine (HMH) and KOH and with water as the control (HMH-Ti C , KOH-Ti C , and H O-Ti C , respectively) are experimentally and theoretically studied. Modification greatly increases the dispersibility of Ti C T flakes.

ADTRP regulates TFPI expression via transcription factor POU1F1 involved in coronary artery disease.

Genomic variants in both ADTRP and TFPI genes are associated with risk of coronary artery disease (CAD). ADTRP regulates TFPI expression and endothelial cell functions involved in the initiation of atherosclerotic CAD. ADTRP also specifies primitive myelopoiesis and definitive hematopoiesis by upregulating TFPI expression.

Generating Bacterial Foods in Toxicology Studies with Caenorhabditis elegans.

Caenorhabditis elegans is a free-living animal that is used as a powerful experimental model in biological sciences. The natural habitat of the animal are areas rich in material from rotting plants or fruits being decomposed by a growing number of microorganisms. The ecology of the natural habitat of C.

The simultaneous removal of the combined pollutants of hexavalent chromium and o-nitrophenol by Chlamydomonas reinhardtii.

Microalgae have been used for the removal of heavy metals or synthetic organics; however, the simultaneous removal of both types of compounds is always technically difficult. In this study, a green algae, Chlamydomonas reinhardtii, was first used to simultaneously remove hexavalent chromium [Cr(VI)] and o-nitrophenol (ONP), and the balance among biomass, oxidative damage and removal rate was also investigated. The results showed that treatment with Cr(VI) or ONP decreased the photosynthetic and superoxide dismutase activities and increased the production of reactive oxygen species (ROS) and malondialdehyde content.

Construction and visible-light-photocatalysis of a novel ternary heterostructure BiOI/(001)TiO/TiC.

Constructing effective heterojunctions between semiconductors and appropriate cocatalysts and exposing highly active crystal facets have been considered an effective approach to obtain efficient photocatalysts. Herein, a novel BiOI/(001)TiO/TiC (BTT) hybrid was for the first time synthesized by in situ growing (001)TiO nanosheets on a 2D MXene nanomaterial (TiC) and subsequent deposition of flower-like nanoflake BiOI on the obtained (001)TiO/TiC hybrid. The BTT hybrid exhibited excellent photocatalytic performance for degradation of Rhodamine B under visible light irradiation, with the highest degradation rate being 6.

The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ).

Background: The progression of colorectal cancer (CRC) mainly stems from the occurrence of somatic mutation. However, there is little information that can be used to comprehensively analyse the importance of germline variants in CRC patients.

Patients And Methods: The candidate germline variants between tumor relapse and cured rectal adenocarcinoma (READ) were firstly filtered by whole-exome sequencing (n=4), and validated by targeted sequencing and associated with clinical outcome in READ (n=48).

High neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predict poor survival in rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy.

This study explored the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy (CCRT).Between January 2006 and December 2016, 184 patients with newly-diagnosed rectal cancer receiving neoadjuvant CCRT were enrolled. Risk of overall survival (OS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method and Cox proportional hazard models.

Molecular Sieving of C -C Alkene from Alkyne with Tuned Threshold Pressure in Robust Layered Metal-Organic Frameworks.

C -C alkyne/alkene separation is of great importance; however, designing materials for an efficient molecular sieving of alkenes from alkynes remains challenging. Now, two hydrolytically stable layered MOFs, [Cu(dps) (GeF )] (GeFSIX-dps-Cu, dps=4,4'-dipyridylsulfide) and [Zn(dps) (GeF )] (GeFSIX-dps-Zn), can achieve almost complete exclusion of both C H and C H from their alkyne analogues. GeFSIX-dps-Cu displays a notable advanced threshold pressure for alkynes adsorption and thus substantial uptakes at lower pressures, providing record C H /C H uptake ratios and capacity-enhanced C H /C H sieving for a wide composition range.

Synchronous degradation of phenol and aniline by sp.strain PB-1entrapped in sodium alginate-bamboo charcoal-chitosan beads.

The biodegradation of benzene series compounds is a difficult problem in environment pollution control, which is attributed to the deficiency of high efficiency bacteria and suitable embedding materials. In this study, the immobilized cells sp. strain PB-1 was used to synchronously biodegrade phenol and aniline by entrapped in sodium alginate (SA)-bamboo charcoal (BC)-chitosan acetate (CA) beads.

DHRS12 inhibits the proliferation and metastasis of osteosarcoma via Wnt3a/β-catenin pathway.

This experimental design was based on DHRS12 to explore its biological effects on osteosarcoma (OS). The expression level of endogenous DHRS12 was analyzed by immunohistochemical analysis. DHRS12 was overexpressed in MG-63 and HOS cells by plasmid transfection.

Therapeutic Efficacy of the N,N' Bis-(2-Mercaptoethyl) Isophthalamide Chelator for Methylmercury Intoxication in Caenorhabditis elegans.

Methylmercury (MeHg) is a global pollutant and potent neurotoxin. In humans, MeHg damages the central nervous system (CNS), causing irreversible neuronal shrinkage, and neuronal loss. Most chelators for clinical mercury detoxification are thiol-containing agents.

Cytotoxic and anti-inflammatory effects of lignans and diterpenes from Cupressus macrocarpa.

Cupressus macrocarpa is a windbreak tree and is reported to have various cytotoxic effects. A natural product study on the leaves of C. macrocarpa has yielded ten secondary metabolites, including three new diterpenoids (1-3), four known diterpenoids (4-7), and three known lignans (8-10).

PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells.

Myoblast fusion is required for myotube formation during myogenesis, and defects in myoblast differentiation and fusion have been implicated in a number of diseases, including human rhabdomyosarcoma. Although transcriptional regulation of the myogenic program has been studied extensively, the mechanisms controlling myoblast fusion remain largely unknown. This study identified and characterized the dynamics of a distinct class of blebs, termed bubbling blebs, which are smaller than those that participate in migration.

Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia.

Ischemic postconditioning (PC) is proved to efficiently protect diabetic patients with acute myocardial infarction from ischemia-reperfusion injury. We aimed to explore the protective roles of ischemic PC on diabetic retinopathy in tree shrews with diabetic cerebral ischemia. A diabetic tree shrew model was established through high-fat diet feeding combined with streptozotocin (STZ) injection, while cortical thrombotic cerebral ischemia was induced photochemically.

Development of a Current Collector with a Graphene Thin Film for a Proton Exchange Membrane Fuel Cell Module.

This paper constructs planar-type graphene thin film current collectors for proton exchange membrane fuel cells (PEMFCs). The present planar-type current collector adopts FR-4 as the substrate and coats a copper thin film using thermal evaporation for the electric-conduction layer. A graphene thin film is then coated onto the current collector to prevent corrosion due to electrochemical reactions.

Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer.

Programmed cell death-1 (PD-1) has demonstrated impressive clinical outcomes in several malignancies, but its therapeutic efficacy in the majority of colorectal cancers is still low. Therefore, methods to improve its therapeutic efficacy in colorectal cancer (CRC) patients need further investigation. Here, we demonstrate that immunogenic chemotherapeutic agents trigger the induction of tumor PD-L1 expression in vitro and in vivo, a fact which was validated in metastatic CRC patients who received preoperatively neoadjuvant chemotherapy (neoCT) treatment, suggesting that tumor PD-L1 upregulation by chemotherapeutic regimen is more feasible via PD-1/PD-L1 immunotherapy.

Identifying the influencing factors controlling the spatial variation of heavy metals in suburban soil using spatial regression models.

Determining the factors that control the spatial variation of heavy metals in suburban soil is important in identifying and preventing pollution sources. Soil intrinsic factors combined with environmental variables can effectively explain the spatial distribution of heavy metals. Compared with classical statistical methods, such as multiple linear regression (MLR) models, spatial regression models that can cope with the spatial dependence of heavy metals have greater potential in establishing an accurate relationship between influencing factors and heavy metals.