Publications by authors named "Ke Ma"

Background: Studies on the associations between nutrient supplement, physical exercise, and depression among persons 65 years and older in China are still lacking. We aimed to investigate the association between nutrient supplement and depression and to explore the role of physical exercise in this association.

Methods: A total of 8,427 older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey were included in this study.

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Objective: To investigate the clinical and immunological characteristics of anti-synthetase syndrome (ASS) patients overlap with rheumatoid arthritis (RA).

Methods: A retrospective analysis was conducted on ASS patients with arthritis who were treated at Peking University People' s Hospital. Data collected included demographic information, clinical manifestations, laboratory features, lymphocyte subsets in peripheral blood, and treatments.

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Developing versatile photosensitizers to actualize selective antibacteria over normal cells presents an appealing yet significantly challenging task. In this study, a novel photosensitizer named DMMA-SCPI is rationally designed and facilely synthesized, which is demonstrated as a type-I photosensitizer featured by aggregation-induced emission tendency. DMMA-SCPI is capable of effectively eliminating both Galanz positive bacteria and Galanz negative bacteria in vitro and in vivo, and showed insignificant injury to normal cells and tissues, probably resulting from its pyridinium halide that has stronger adsorption property on negatively charged bacteria compared to normal cells, as well as its suitable antimicrobial activity.

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  • * FMDV proteins 2B and 3C are found to decrease STING expression; 3C does this via its protease activity while 2B recruits YTHDF2 to halt STING mRNA production, enhancing viral replication.
  • * Mice lacking YTHDF2 showed stronger resistance to FMDV, highlighting the role of YTHDF2 in FMDV infection and suggesting new avenues for understanding immune evasion by the virus.
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Artificial intelligence (AI), particularly large language models like GPT-4o, holds promise for enhancing diagnostic accuracy in healthcare. This study evaluates the diagnostic performance of GPT-4o compared to human ophthalmologists in glaucoma cases. A prospective, observational study was conducted at a tertiary care ophthalmology center.

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Splicing factor proline-glutamine rich (SFPQ), a multifunctional RNA-binding protein (RBP), shows cytoplasmic colocalisation with stress granule (SG) markers; however, the causative relationship and mechanism underlying this coalescence of SFPQ aggregates and SGs remain unclear. In this study, we demonstrate that SFPQ lacking its nuclear localisation sequence spontaneously forms cytoplasmic aggregates that abnormally incorporate immature RNA and induce persistent SGs. mRNA profiling showed that SFPQ mislocalisation induced extensive changes in RNA processing, with a subset of alternatively spliced transcripts associated with nucleocytoplasmic transport.

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  • * This study investigates how storage conditions (25°C vs. 4°C) affect the metabolic changes and quality preservation of blue honeysuckle fruit, finding that lower temperatures significantly slow decay and maintain better fruit quality.
  • * Researchers identified 24 key metabolites involved in the fruit's deterioration and linked these to specific genes and transcription factors, providing insight into potential methods for improving the berry’s flavor and storage longevity.
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The possible cognitive effect of sense of agency (SoA) has attracted increasing attention. Previous findings suggest that SoA has an effect on action control, time perception, and memory. Here we investigated whether SoA can also influence decision-making.

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  • * The study reports the first experimental generation of GQKSs from a fiber laser, revealing that their temporal and spectral characteristics are influenced by factors like quadratic dispersion, pump power, and intra-cavity birefringence.
  • * Different soliton states, such as harmonic mode-locking and soliton bunches, were observed through careful manipulation of quadratic and quartic dispersion values, helping to deepen understanding of
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Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis that can lead to joint deformities. To date, more than 18 million individuals worldwide have been diagnosed with RA, making it one of the most prevalent autoimmune diseases globally and posing a significant threat to public health and safety. Due to the complex pathogenesis of the disease, which involves autoimmunity, genetics, inflammation and oxidative stress in the body's tissues, the current drug therapy generally targets a single molecule, and effective and efficient drugs involving multiple levels and targets are lacking; thus, there is an urgent need for high-quality research and treatment in this field.

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Objective: To screen and identify potential biomarker for early rheumatoid arthritis (RA) by bioinformatic analysis and experimental investigation.

Methods: Transcriptome data of RA synovium was downloaded from GEO. Differentially expressed genes (DEGs), gene ontology (GO) functional annotation, and KEGG pathway were analyzed to inspect significative target genes.

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  • MERS-CoV and MjHKU4r-CoV-1 use DPP4 as a receptor to enter cells, with MjHKU4r-CoV-1 able to infect transgenic mice that have human DPP4.
  • Researchers analyzed the crystal structures of MjHKU4r-CoV-1's receptor binding domain (RBD) bound to both human and pangolin DPP4 to understand how it enters cells.
  • The study found that MjHKU4r-CoV-1 has a stronger affinity for human DPP4 than a related bat coronavirus, indicating it may be better adapted for human infection, raising concerns about potential virus transmission to humans.
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The limited therapeutic options for diabetic tubulopathy (DT) in early diabetic kidney disease (DKD) reflect the difficulty of targeting renal tubular compartment. While renin-angiotensin-aldosterone system (RAS) inhibitors are commonly utilized in the management of DKD, how intrarenal RAS contributes to diabetic tubular injury is not fully understood. Mitochondrial disruption and reactive oxygen species (ROS) overgeneration have been involved in diabetic tubular injury.

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The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment in numerous cancer indications. Of particular interest is nanoscale photosensitizer-based phototherapy, which has been established as a prominent candidate for advanced tumor treatment by virtue of its high efficacy and safety. Despite considerable research progress on materials, methods and devices in nanoscale photosensitizing agent-based phototherapy, their mechanisms of action are not always clear, which impedes their practical application in cancer treatment.

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Introduction: Preoperative inspiratory muscle training (IMT) is recognised as an important component of the preoperative management of lung cancer, although there is limited evidence for the delivery of a home-based IMT programme combined with preoperative education. We developed a programme combining short-term home-based IMT and preoperative physiotherapy education ('the programme'). This study aims to evaluate the effectiveness of this programme in reducing postoperative pulmonary complications (PPCs) after lung cancer resection compared with standard care.

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Despite the outstanding electric properties and cost-effectiveness of poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives, their performance as hole transport layer (HTL) materials in conventional perovskite solar cells (PSCs) has lagged behind that of widely used spirobifluorene-based molecules or poly(triaryl amine). This gap is mainly from their poor solubility and energy alignment mismatch. In this work, the design and synthesis of a pyrrole-modified HTL (PPr) based on 3,4-propylenedioxythiophene (ProDOT) are presented for efficient and stable PSCs.

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  • Researchers developed a new type of nanoprodrug called BNN6@GBTC NPs, made from an amphiphilic prodrug (GBTC) and a nitric oxide donor (BNN6), which self-assemble into stable nanoparticles.
  • These nanoparticles can target HepG2 cancer cells specifically, thanks to galactose receptors on the cell surface, and generate reactive oxygen species (ROS) when exposed to light.
  • The combination of photodynamic therapy, chemotherapy through the release of camptothecin, and gas therapy using nitric oxide leads to a more effective cancer treatment while minimizing damage to healthy cells.
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  • A study investigates the effectiveness of spinal cord stimulation (SCS) combined with dorsal root ganglion (DRG) pulsed radiofrequency (PRF) in treating zoster-associated pain (ZAP), comparing it to SCS alone.
  • Results showed that while VAS scores were similar at the start and discharge, the SCS+PRF group had significantly lower pain scores at a 6-month follow-up and fewer patients experienced residual moderate pain.
  • Additionally, no patients in the SCS+PRF group progressed to postherpetic neuralgia, indicating that this combined treatment may be a better option for managing ZAP.
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Enzymes from the nuclear transport factor 2-like (NTF2-like) superfamily represent a rare group of biocatalysts with diverse catalytic functions facilitating intriguing skeleton formations. However, most proteins of this family remain enigmatic and await further elucidation. In this study, a combination of protein structural alignment with clustering analysis uncovers a new aldolase, AtoB, belonging to the NTF2-like superfamily.

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  • Automated Vehicles (AVs) have the potential to improve transportation significantly, but current datasets used to study their behavior are often inadequate in quality and completeness, which affects analysis and model development.
  • This study introduces the Unified longitudinal trajectory dataset for AVs (Ultra-AV), which compiles data from 14 different sources to better analyze AVs' driving behaviors through a meticulous three-step data processing method.
  • The processed dataset is validated through various performance evaluations, providing researchers with standardized metrics and guidelines for future AV behavior studies and model development.
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Industry-produced hydrazine (NH) is released into the environment, posing a major risk to human health and the ecosystem. Therefore, it is imperative to develop an effective and convenient method for the detection of NH. Herein, artificial light-harvesting systems (ALHSs) for NH detection were constructed by applying an aggregation-induced emission-active platinum(II) metallacycle () as the energy donor and rhodols (, , and ) as the energy acceptors.

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Background: Dorsal ramus medial branch radiofrequency ablation is reported to be effective for refractory lumbar facet joint syndrome. However, as nerve fibers can regenerate, the therapeutic effect was reported to be short and last only 6 to 12 months. Previously, we reported a novel endoscopic joint capsule and articular process excision procedure.

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Background: In locally advanced, operable esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (nICT) has shown results that are somewhat comparable to those of standard neoadjuvant chemoradiotherapy (nCRT). The impact of these neoadjuvant treatments on survival outcomes, however, has yet to be elucidated.

Methods: This study included 489 patients with locally advanced ESCC who underwent surgery at Sichuan Cancer Hospital after receiving neoadjuvant treatment between June 2017 and September 2023.

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