Potential magnetic structure in Eu3InAs3 revealed by magnetization and thermodynamic study.

We systematically investigate the magnetization and thermodynamic responses associated with antiferromagnetic (AFM) transitions in single crystals of the magnetic semiconductor Eu3InAs3. The linear thermal expansion measurements around the AFM transition temperatures, TN1 and TN2, indicate an expansion along the a axis and contraction along the b and c axes. The calculated ∆V/V(T) shows a continuous change at TN, indicating a second-order magnetic phase transition.

Optimizing Acidic Oxygen Evolution Reaction via Modulation Doping in Van der Waals Layered Iridium Oxide.

Anodic oxygen evolution reaction (OER) exhibits a sluggish four-electron transfer process, necessitating catalysts with exceptional catalytic activity to enhance its kinetic rate. Van der Waals layered oxides are ideal materials for catalyst design, yet its stability for acidic OER remains large obstacle. Doping provides a crucial way to improve the activity and stability simultaneously.

Anatomic association between the gastrocolic trunk of Henle and right colic artery by high-quality CT venography.

In hepatic flexure and transverse colon cancer surgeries, mobilizing the right mesocolon and precisely dissecting the gastrocolic trunk of Henle (GTH) are crucial. Previous classifications of GTH tributaries do not guide radical right hemicolectomy due to post-procedural anatomical acquisition. This study analyzed vessel associations, including the middle colic vein (MCV) converging site, right colic artery (RCA) presence, and other GTH tributaries, using ultra-thin CT for reconstruction.

Microglia membrane-mediated trans-blood-brain barrier prodrug micelles enhance phagocytosis for glioblastoma chemo-immunotherapy.

Glioblastoma-associated macrophages & microglia (GAMs) are critical immune cells within the glioblastoma (GBM) microenvironment. Their phagocytosis of GBM cells is crucial for initiating both innate and adaptive immune responses. GBM cells evade this immune attack by upregulating the anti-phagocytic molecule CD47 on their surface.

Optimizing Acidic Oxygen Evolution with Manganese-Doped Ruthenium Dioxide Assembly.

Ruthenium dioxide (RuO) is one of the promising catalysts for the acidic oxygen evolution reaction (OER). However, designing RuO catalysts with good activity and stability remains a significant challenge. In this work, we propose the manganese (Mn)-doped RuO assembly as a catalyst for the OER with improved activity and stability.

Transcriptomics and metabolomics insights into the seasonal dynamics of meat quality in yak on the Qinghai-Tibetan Plateau.

Background: Meat quality in yak is influenced by the fluctuation of nutritional composition in different grazing seasons on the Qinghai-Tibetan Plateau. However, the molecular mechanism underlying in yak meat remains unknown. Therefore, this study aimed to investigate the seasonal dynamics of meat quality in yak by transcriptomics and metabolomics techniques.

Signaling pathways and targeted therapies in Ewing sarcoma.

Ewing sarcoma, the second most prevalent malignant bone tumor with potential occurrence in soft tissues, exhibits a high level of aggressiveness, primarily afflicting children and adolescents. It is characterized by fusion proteins arising from chromosomal translocations. The fusion proteins induce aberrations in multiple signaling pathways and molecules, constituting a key event in oncogenic transformation.

Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.

Background And Purpose: Neurodevelopmental disorders (NDDs) are characterized by abnormalities in brain development and neurobehaviors, including autism. The maternal-fetal interface (MFI) is a highly specialized tissue through which maternal factors affect fetal brain development. However, limited research exists on restoring and maintaining MFI homeostasis and its potential impact on NDDs.

Imaging and observation of microcirculation in bowel mucosa using sidestream dark field imaging.

Sidestream dark field (SDF) imaging is a tool for assessing microcirculation, commonly used for early diagnosis and monitoring of sepsis. In this study, we used SDF imaging to observe and assess the microcirculation of the intestinal mucosa during bowel surgery. We also compared different performance between normal mucosa and diseased mucosa using SDF imaging.

Influenza and the gut microbiota: A hidden therapeutic link.

Background: The extensive community of gut microbiota significantly influences various biological functions throughout the body, making its characterization a focal point in biomedicine research. Over the past few decades, studies have revealed a potential link between specific gut bacteria, their associated metabolic pathways, and influenza. Bacterial metabolites can communicate directly or indirectly with organs beyond the gut via the intestinal barrier, thereby impacting the physiological functions of the host.

[Mechanism of Xuanbai Chengqi Decoction in treating acute lung injury based on network pharmacology and experimental verification].

This study aims to investigate the mechanism of Xuanbai Chengqi Decoction in treating acute lung injury(ALI) based on network pharmacology and animal experiments. The potential targets and signaling pathways of Xuanbai Chengqi Decoction in regulating ALI were predicted by network pharmacology. The rat model of ALI was constructed and administrated with different doses of Xuanbai Chengqi Decoction.

Super-resolution landmark detection networks for medical images.

Craniomaxillofacial (CMF) and nasal landmark detection are fundamental components in computer-assisted surgery. Medical landmark detection method includes regression-based and heatmap-based methods, and heatmap-based methods are among the main methodology branches. The method relies on high-resolution (HR) features containing more location information to reduce the network error caused by sub-pixel location.

Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn's disease.

Background: Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat, is a pathologic characteristic of Crohn's disease (CD). In our previously reported cohort, we observed that Achromobacter pulmonis was the most abundant and prevalent bacteria cultivated from creeping fat.

Methods: A whole genomic sequencing and identification of T3SS orthologs of mAT-derived A.

Multimodal Distillation Pre-training Model for Ultrasound Dynamic Images Annotation.

With the development of medical technology, ultrasonography has become an important diagnostic method in doctors' clinical work. However, compared with the static medical image processing work such as CT, MRI, etc., which has more research bases, ultrasonography is a dynamic medical image similar to video, which is captured and generated by a real-time moving probe, so how to deal with the video data in the medical field and cross modal extraction of the textual semantics in the medical video is a difficult problem that needs to be researched.

High-Performance Metabolic Profiling of High-Risk Thyroid Nodules by ZrMOF Hybrids.

Thyroid nodules (TNs) have emerged as the most prevalent endocrine disorder in China. Fine-needle aspiration (FNA) remains the standard diagnostic method for assessing TN malignancy, although a majority of FNA results indicate benign conditions. Balancing diagnostic accuracy while mitigating overdiagnosis in patients with benign nodules poses a significant clinical challenge.

Recurrent inhibition refines mental templates to optimize perceptual decisions.

Translating sensory inputs to perceptual decisions relies on building internal representations of features critical for solving complex tasks. Yet, we still lack a mechanistic account of how the brain forms these mental templates of task-relevant features to optimize decision-making. Here, we provide evidence for recurrent inhibition: an experience-dependent plasticity mechanism that refines mental templates by enhancing γ-aminobutyric acid (GABA)-mediated (GABAergic) inhibition and recurrent processing in superficial visual cortex layers.

Chirality-Dependent Reprogramming of Macrophages.

The chirality of materials directly influences their transport and biological effects in physiological conditions. However, the impact of chiral materials on cellular metabolic reprogramming remains incompletely elucidated. In this study, we have synthesized chiral gold particles through a light-driven particle growth approach and demonstrated that d-Au particles exhibited superior macrophage activation ability compared to l-Au particles.

Synchronized lineage tracing of cell membranes and nuclei by dual recombinases and dual fluorescent.

Genetic lineage tracing has been widely employed to investigate cell lineages and fate. However, conventional reporting systems often label the entire cytoplasm, making it challenging to discern cell boundaries. Additionally, single Cre-loxP recombination systems have limitations in tracing specific cell populations.

The impact of Astragaloside IV on the inflammatory response and gut microbiota in cases of acute lung injury is examined through the utilization of the PI3K/AKT/mTOR pathway.

Objectives: Astragaloside IV (AS-IV) is a natural triterpenoid saponin compound with a variety of pharmacological effects, and several studies have clarified its anti-inflammatory effects, which may make it an effective alternative treatment against inflammation. In the study, we aimed to investigate whether AS-IV could attenuate the inflammatory response to acute lung injury and its mechanisms.

Methods: Different doses of AS-IV (20mg·kg-1, 40mg·kg-1, and 80mg·kg-1) were administered to the ALI rat model, followed by collection of serum and broncho alveolar lavage fluid (BALF) for examination of the inflammatory response, and HE staining of the lung and colon tissues, and interpretation of the potential molecular mechanisms by quantitative real-time PCR (qRT-PCR), Western blotting (WB).