The burden of acute respiratory infection in children under 5 attributable to economic inequality in low- and middle-income countries.

Background: Quantifying the disease burden among children that could potentially be reduced through improvements in individual economic status and regional economic equality can greatly benefit policy making and resource allocation. However, such quantification has rarely been done. This study aimed to assess the inequality-related burden of acute respiratory infection (ARI) (the leading cause of child mortality in low- and middle-income countries (LMICs)) among under five children.

Nearly Optimal Learning Using Sparse Deep ReLU Networks in Regularized Empirical Risk Minimization With Lipschitz Loss.

We propose a sparse deep ReLU network (SDRN) estimator of the regression function obtained from regularized empirical risk minimization with a Lipschitz loss function. Our framework can be applied to a variety of regression and classification problems. We establish novel nonasymptotic excess risk bounds for our SDRN estimator when the regression function belongs to a Sobolev space with mixed derivatives.

Novel fabrication of hydroxypropyl-β-cyclodextrin functionalized zein protein nanoparticles Co-encapsulated with bio-molecules to attenuate pregnancy-induced hypertension by inducing trophoblast cells proliferation with TLR4 signaling pathway.

Trophoblast dysfunction during pregnancy time is majorly involved to lead pathogenesis of preeclampsia. In the present investigation, the facile nanoformulation by Zein protein particles functionalized with hydroxypropyl-beta-cyclodextrin (β-CD) and co-encapsulated with curcumin and eugenol compounds (Cu/Eu@H-β-CD-ZNPs) is developed to achieve enhanced therapeutic potential in the treatment of preeclampsia. To investigate the positive trophoblast function, trophoblast cells were treated and observed for in vitro cell proliferation, invasion and migration ability under hypoxic condition.

A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of SM-1.

Arsenic is the most common toxic metalloid in the environment. Nearly all organisms have genes for arsenic detoxification. Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance () operons, which are commonly regulated by members of the ArsR transcriptional repressors.

Relationship between diabetes-related clinical characteristics and preserved ratio impaired spirometry (PRISm): findings from NHANES 2007-2012.

Introduction: To analyse the relationship between diabetes, its severity (including blood glucose levels, disease duration, antidiabetic drug use and number of comorbidities) and preserved ratio impaired spirometry (PRISm) using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: This cross-sectional study collected data from the NHANES database from 2007 to 2012. PRISm was defined as having a forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio ≥0.

Efficient intelligent fault diagnosis method and graphical user interface development based on fusion of convolutional networks and vision transformers characteristics.

Convolutional Neural Networks have been widely applied in fault diagnosis tasks of mechanical systems due to their strong feature extraction and classification capabilities. However, they have limitations in handling global context information. Vision Transformers, by leveraging self-attention mechanisms to capture global dependencies, have shown excellent performance in many visual tasks, but often come with high computational costs.

Ag-Mediated DNA Nanomachine Cascade Nanomaterial Amplification Enable One-Pot Electrochemical Analysis of Circulating Tumor DNA.

Circular tumor DNA (ctDNA) is a trace nucleic acid that functions as an essential tumor marker. In this context, the present study proposes a one-pot electrochemical analysis of ctDNA EGFR L858R in lung cancer leveraging a Ag-mediated DNA nanosphere (I amplification) and cation exchange reaction (II amplification), and Cu acts as a signal molecule. Once the target L858R exists, it specifically destroys the structure of DNA nanosphere@Ag, and large amounts of Ag are released.

Clinical Features of Seven COL2A1 Variations in Chinese Children With Type II Collagen Disorders.

Aim: Type II collagen, encoded by the collagen type II alpha 1 (COL2A1) gene, is crucial for the structure of cartilage. This study aims to improve our understanding of Spondyloepiphyseal Dysplasia Congenita (SEDC) caused by mutations in COL2A1. We also aim to evaluate the safety and efficacy of growth hormone (GH) therapy in two SEDC patients.

Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations: A Prospective Cohort Study from China.

Objective: The relationship between fish consumption and stroke is inconsistent, and it is uncertain whether this association varies across predicted stroke risks.

Methods: A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted. A standardized questionnaire was used to collect data on fish consumption.

Inferring cell trajectories of spatial transcriptomics via optimal transport analysis.

The integration of cell transcriptomics and spatial position to organize differentiation trajectories remains a challenge. Here, we introduce SpaTrack, which leverages optimal transport to reconcile both gene expression and spatial position from spatial transcriptomics into the transition costs, thereby reconstructing cell differentiation. SpaTrack can construct detailed spatial trajectories that reflect the differentiation topology and trace cell dynamics across multiple samples over temporal intervals.

Identification of the regulatory role of SsMYBS25-4 in salt stress from MYB-related transcription factors in sugarcane (Saccharum spontaneum).

Sugarcane is a highly valued crop known for its significant production of sugar and biomass. MYB transcription factors (TFs) are critical regulators in plant growth and stress tolerance, but MYB-related genes, an atypical subset of the MYB family, remain less explored. In this study, we identified 119 MYB-related genes in the genome of wild sugarcane (S.

One Step Visual Homogeneous Immunoassay of a Rheumatoid Arthritis Biomarker in Serum via Target-Regulated Steric Hindrance and Competitive Recognition.

Homogeneous analysis techniques offer several advantages as alternatives to heterogeneous immunoassays, such as simplicity and rapidity. In this study, a visual homogeneous immunoassay without a labeling process was developed based on target-induced steric hindrance to regulate competitive recognition mechanism. Specifically, as the analyte concentration varies, the change of microenvironment based on steric hindrance could affect the recognition of Cu by signal probes.

Long-term exposure to fine particulate matter components with obesity in children and adolescents in China: The age-sex disparities and key effect modifiers.

Long-term fine particulate matter (PM) exposure was associated with childhood obesity. However, the key PM components and whether PM effect may vary by obesity type, growth stage, sex, and individual/family characteristics have yet been examined. In this study, we investigated 213,907 Chinese children and adolescents aged 3-18 years in 2017-2019.

Clinical Performance of MAGLUMI Diagnostic Tests for the Automated Detection of Dengue Virus.

Aims: The screening and diagnosis of dengue virus infection play a crucial role in controlling the epidemic of dengue fever, highlighting the urgent need for a highly sensitive, simple, and rapid laboratory testing method. This study aims to assess the clinical performance of MAGLUMI Denv NS1 in detecting dengue virus NS1 antigen.

Methods: A retrospective study was conducted to assess the sensitivity and specificity of MAGLUMI Denv NS1 using residual samples.

Alleviation effect of taxifolin on diquat-induced damage to porcine intestinal epithelial cells.

Oxidative stress is considered to be a major cause of numerous intestinal diseases, and taxifolin (TA) possesses a variety of pharmacological properties that promote health and prevent disease. This study intends to determine the ability of TA to alleviate oxidative stress induced by diquat (DIQ) in porcine intestinal epithelial cells (IPEC-J2 cells). After being pretreated with 150 μM TA for 24 h, IPEC-J2 cells were treated with 0.

Smart Vascular Grafts with Integrated Flow Biosensors for Hemodynamic Real-Time Monitoring and Vascular Healthcare.

Real-time monitoring of hemodynamics is crucial for diagnosing disorders within implanted vascular grafts and facilitating timely treatment. Integrating vascular grafts with advanced flexible electronics offers a promising approach to developing smart vascular grafts (SVGs) capable of continuous hemodynamic monitoring. However, most existing SVG devices encounter significant challenges in practical applications, particularly regarding biomechanical compatibility and the effective evaluation of vascular status.

Using the Regression Slope of Training Loss to Optimize Chest X-ray Generation in Deep Convolutional Generative Adversarial Networks.

Diffusion models, variational autoencoders, and generative adversarial networks (GANs) are three common types of generative artificial intelligence models for image generation. Among these, GANs are the most frequently used for medical image generation and are often employed for data augmentation in various studies. However, due to the adversarial nature of GANs, where the generator and discriminator compete against each other, the training process can sometimes end with the model unable to generate meaningful images or even producing noise.

Trends in infections in pediatric patient preceding, during, and following the COVID-19 pandemic: a comprehensive longitudinal analysis.

Unlabelled: This study investigated the impact of the coronavirus disease 2019 (COVID-19) pandemic and its associated restrictive measures on infections in children with acute respiratory tract infection. The study aimed to elucidate the epidemiological characteristics of infections before and during the pandemic and following the easing of restrictive measures. Pharyngeal secretions were collected from 1,0174 pediatric patients with acute respiratory infection (ARI) who were admitted to Shaoxing Maternity and Child Health Care Hospital (Shaoxing, China) between May 2018 and December 2023.

Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections.

Diabetic wounds often exhibit a chronic non-healing state due to the combined effects of multiple factors, including hyperglycemia, impaired angiogenesis, immune dysfunction, bacterial infection, and excessive oxidative stress. Despite the availability of various therapeutic strategies, effectively managing the complex and prolonged healing process of diabetic infected wounds remains challenging. In this study, we combined the natural antidiabetic drug lipoic acid (LA) with the RADA16-YIGSR (RY) peptide obtained through solid-phase synthesis, utilizing reversible hydrogen bonds and coordination bonds for binding.

A Magnetic Photocatalytic Composite Derived from Waste Rice Noodle and Red Mud.

This study is the first to convert two waste materials, waste rice noodles (WRN) and red mud (RM), into a low-cost, high-value magnetic photocatalytic composite. WRN was processed via a hydrothermal method to produce a solution containing carbon quantum dots (CQDs). Simultaneously, RM was dissolved in acid to form a Fe ion-rich solution, which was subsequently mixed with the CQDs solution and underwent hydrothermal treatment.

Improving sulforaphane content in broccoli sprouts by applying Se: transcriptome profiling and coexpression network analysis provide insights into the mechanistic response.

Sulforaphane (SF) is a sulfur (S)-containing isothiocyanate found in cruciferous vegetables and is known for its potent anticancer properties. Broccoli sprouts, in particular, are considered safe and healthy dietary choices due to their high SF content and other beneficial biological activities, such as enhanced metabolite ingestion. The application of selenium (Se) is an excellent approach to enhance the abundance of SF.

Circular mRNA Vaccine against SARS-COV-2 Variants Enabled by Degradable Lipid Nanoparticles.

The emergence of mRNA vaccines offers great promise and a potent platform in combating various diseases, notably COVID-19. Nevertheless, challenges such as inherent instability and potential side effects of current delivery systems underscore the critical need for the advancement of stable, safe, and efficacious mRNA vaccines. In this study, a robust mRNA vaccine (cmRNA-1130) eliciting potent immune activation has been developed from a biodegradable lipid with eight ester bonds in the branched tail (AX4) and synthetic circular mRNA (cmRNA) encoding the trimeric Delta receptor binding domain of the SARS-CoV-2 spike protein.

ROS, an Important Plant Growth Regulator in Root Growth and Development: Functional Genes and Mechanism.

Roots are fundamental to the growth, development, and survival of plants. Beyond anchoring the plant, roots absorb water and nutrients, supporting the plant's ability to grow and function normally. Root systems, originating from the apical meristem, exhibit significant diversity depending on the plant species.

Nebulized Lipid Nanoparticles Based on Degradable Ionizable Glycerolipid for Potent Pulmonary mRNA Delivery.

As an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles (LNPs) from degradable ionizable glycerolipids for potent pulmonary mRNA delivery via nebulization.