Application of the Electrospinning Technique in Electrochemical Biosensors: An Overview.

Electrospinning is a cost-effective and flexible technology for producing nanofibers with large specific surface areas, functionalized surfaces, and stable structures. In recent years, electrospun nanofibers have attracted more and more attention in electrochemical biosensors due to their excellent morphological and structural properties. This review outlines the principle of electrospinning technology.

Static and Dynamic Plantar Pressure Distribution in 94 Patients with Different Stages of Unilateral Knee Osteoarthritis Using the Footscan® Platform System: An Observational Study.

BACKGROUND Plantar pressure analysis is widely used in the study of knee osteoarthritis (KOA). The present study aimed to investigate the static and dynamic plantar pressure distribution in patients with different stages of unilateral KOA using the Footscan® platform system. MATERIAL AND METHODS We recruited 94 patients aged 61.

Coaxial electrospinning synthesis of size-tunable CuO/NiO hollow heterostructured nanofibers: Towards detection of glucose level in human serum.

Nanofibers (NFs) have found wide applications by virtue of their particular morphology and high specific surface area. In this study, size-tunable hollow CuO/NiO NFs were synthesized by coaxial electrospinning and subsequent calcination. The synthesized hollow CuO/NiO NFs owned large specific surface area for catalytic active sites.

Clinical manifestations and genetic analysis of a newborn with Arboleda-Tham syndrome.

Arboleda-Tham syndrome (ARTHS) is a rare disorder first characterized in 2015 and is caused by mutations in lysine (K) acetyltransferase 6A (KAT6A, a.k.a.

GAS5 Suppresses Cell Proliferation, Migration, and Invasion via the miR-455-5p/CDKN1B Axis in Cutaneous Squamous Cell Carcinoma.

Cutaneous squamous cell carcinoma (cSCC) is a common dermatologic malignancy characterized by aberrant proliferation of keratinocytes. Molecular targeted therapy appears to be a promising approach for advanced cSCC. Long noncoding RNA growth arrest specific 5 (GAS5) was reported to be downregulated in skin cancer tissues.

[Clinical and genetic analysis of a Chinese pedigree affected with benign familial neonatal convulsion].

Objective: To analyze the clinical phenotype and genetic variant in a Chinese pedigree affected with benign familial neonatal convulsion (BFNC).

Methods: Clinical data and peripheral blood samples of the pedigree were obtained with informed consent. Whole exome sequencing (WES) was carried out for the proband.

Renoprotective effect of isoliquiritigenin on cisplatin-induced acute kidney injury through inhibition of FPR2 in macrophage.

Acute kidney injury (AKI) is a serious complication in critically ill patients. Accumulating evidences indicated that macrophages play an important pro-inflammatory role in AKI and isoliquiritigenin (ISL) can inhibit macrophagic inflammation, but its role in AKI and the underlying mechanism are unknown. The present study aims to investigate the renoprotective effect of ISL on AKI and the role of Formyl peptide receptors 2 (FPR2) in this process.

Controlled synthesis of Cu-Sn alloy nanosheet arrays on carbon fiber paper for self-supported nonenzymatic glucose sensing.

Nanoalloy shows significant advantages and broad application prospects in chemical catalysis, due to the possessed high specific surface energy and abundant active sites can greatly promote their catalytic performance. In this work, morphology-controlled Cu-Sn alloy nanosheet arrays supported on carbon fiber paper (CP) substrate (Cu-Sn/CP) have been developed by a facile one-step electrodeposition technique at room temperature for the first time. Benefiting from the large active surface area, considerable ion transport channels and strong synergistic catalytic effect between Cu and Sn, the as-prepared Cu-Sn/CP served as a self-supported electrode for efficient nonenzymatic glucose sensing.

Characterization of umami compounds in bone meal hydrolysate.

The objective of this research was to identify and characterize the chemical compounds that exhibited monosodium glutamate (MSG)-like taste in the hydrolyzed bone meal produced by using flavourzyme. The free amino acids and peptides in the bone meal hydrolysate were analyzed. The results showed that the glutamic acid and the aspartic acid in the bone meal increased by 13.

Columbamine suppresses proliferation and invasion of melanoma cell A375 via HSP90-mediated STAT3 activation.

Purpose: The goal of this study is to explore the effects of columbamine in melanoma cells and the signaling pathway involved.

Methods: Human melanoma cell line A375 cells were used in this study. Cell proliferative ability was detected by MTT assay and clone formation assay.

Glucose sensor based on Pd nanosheets deposited on Cu/CuO nanocomposites by galvanic replacement.

A novel non-enzymatic glucose sensor was established by galvanic replacement synthesis of Pd nanosheets (PdNS) on Cu/CuO nanocomposites using fluorine-doped tin oxide (FTO) substrates. To prepare PdNS-Cu/CuO/FTO electrode, Cu/CuO nanocomposites were firstly deposited on FTO electrode through potential oscillating, and then Pd nanosheets were synthesized on Cu/CuO nanocomposites by galvanic replacement reduction. X-ray diffraction, scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy were applied to investigate the morphology and composition of PdNS-Cu/CuO nanohybrids.

Facile Synthesis of ZnMnO@rGO Microspheres for Ultrasensitive Electrochemical Detection of Hydrogen Peroxide from Human Breast Cancer Cells.

Mixed transition-metal oxides have witnessed increasing attention in catalysts and electrocatalysts. Herein, reduced graphene oxide-wrapped ZnMnO microspheres (ZnMnO@rGO) were facilely synthesized through the solvothermal technique. The microstructure and morphology of ZnMnO@rGO microspheres were analyzed under Raman, X-ray photoelectron, X-ray diffraction, and energy-dispersive spectroscopies and scanning electron microscopy.

Potential effects of umami ingredients on human health: Pros and cons.

Umami taste is the most recent confirmed basic taste in addition to sour, sweet, bitter, and salty. It has been controversial because of its effects on human nutritional benefit. Based on the available literatures, this review categorized 13 positive and negative effects of umami taste on human health.

Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines.

It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs) and inadequate retention within LNs undoubtedly restrains their strength on activating T cell immunity. Here, we address this issue by tailoring the physicochemical properties of polymeric hybrid micelles (HMs), which are self-assembled from two amphiphilic diblock copolymers, poly-(ethylene glycol) phosphorethanolamine (PEG-PE) and polyethylenimine-stearic acid conjugate (PSA) via hydrophobic and electrostatic interactions.

Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment.

Finding effective cures against aggressive malignancy remains a major challenge in cancer chemotherapy. Here, we report a "tadpole"-like peptide by covalently conjugating the alanine-alanine-asparagine "tail" residual to the cyclic tumor homing peptide iRGD (CCRGDKGPDC) to afford nRGD, which significantly enhanced tumoricidal effects of doxorubicin, by either co-administered as a physical mixture or as a targeting ligand covalently conjugated to the liposomal carrier. Given twice at an equivalent dose of 5 mg/kg, doxorubicin loaded liposomes modified with nRGD (nRGD-Lipo-Dox) showed excellent antitumor efficacy in 4T1 breast cancer mice, of which 44.

Rifampicin loaded mannosylated cationic nanostructured lipid carriers for alveolar macrophage-specific delivery.

Purpose: In this study, cationic mannosylated nanostructured lipid carriers (Man-NLCs) were developed for the targeted delivery of rifampicin to alveolar macrophages.

Methods: Rifampicin loaded Man-NLCs (RFP-Man-NLCs) and rifampicin loaded unmodified nanostructured lipid carriers (REP-NLCs) were prepared using thin film homogenization method and characterized by particle size, polydispersity index, zeta potential, transmission electron microscopy, encapsulation efficiency, pharmacokinetics, biodistribution, cell specific targeting, cytotoxicity and inflammatory response.

Results: RFP-Man-NLCs and REP-NLCs obtained displayed a size distribution around 160 nm (PDI <0.