Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy.

The present study aimed to determine the potential of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigen (CA)19-9 and CA242 in predicting recurrence/metastasis of gastric cancer in patients following radical gastrectomy. The clinical data of 368 patients with stage I-III gastric cancer who underwent radical gastrectomy were analyzed, and CEA, AFP, CA19-9 and CA242 levels were detected prior to surgery and 6-12 months following surgery. Univariate and multivariate analyses were used to evaluate the potential risk factors for post-operative recurrence/metastasis of gastric cancer, and the predictive value of CEA, AFP, CA19-9 and CA242 levels was evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC).

Prediction of ischemic stroke in patients with H-type hypertension based on biomarker.

Hypertension combined with hyperhomocysteinemia significantly raises the risk of ischemic stroke. Our study aimed to develop and validate a biomarker-based prediction model for ischemic stroke in Hyperhomocysteinemia-type (H-type) hypertension patients. We retrospectively included 3,305 patients in the development cohort, and externally validated in 103 patients from another cohort.

Epidemiological features of uterine fibroid-associated imaging changes in Chinese women of reproductive age: a retrospective study.

Objectives: To investigate uterine fibroid (UF)-associated imaging changes, and their prevalence, incidence and potential risk factors in the Chinese population.

Design: This was a retrospective observational study using health examination data.

Setting: A physical examination centre in Nanchong, China, between October 2017 and December 2020.

Investigation into the Reinforcement Modification of Natural Plant Fibers and the Sustainable Development of Thermoplastic Natural Plant Fiber Composites.

Natural plant fibers (NPFs) have emerged as a sustainable alternative in the manufacture of composites due to their renewability and low environmental impact. This has led to a significant increase in the use of natural plant fiber-reinforced polymers (NPFRPs) in a variety of industries. The diversity of NPF types brings a wide range of properties and functionalities to NPFRPs, which in turn highlights the urgent need to improve the properties of fiber materials in order to enhance their performance and suitability.

Physiological Responses of and to Combined Stress of Diesel Fuel and Sr Stress in Soil.

Diesel spills and nuclides pollution cause global ecosystem and human health problems. The remediation of contaminated soil using woody plants has received considerable attention. Differences in plant species and sex can lead to differences in tolerance to various stressors.

Functions of Insulin-like Peptide Genes ( and ) in Female Reproduction of the Predatory Ladybird (Coleoptera: Coccinellidae).

Insulin-like peptides (ILPs) are important peptide hormones in insects, particularly involved in regulating physiological processes such as growth, development, and reproduction. However, the specific roles of ILPs in the reproduction of natural enemy insects remain unknown. In this study, two ILP genes, and , were cloned and their functions were analyzed in female L.

Amelioration of LPS-Induced Jejunum Injury and Mucus Barrier Damage in Mice by IgY Embedded in W/O/W Emulsion.

Chicken yolk immunoglobulin (IgY) is a natural immunologically active antibody extracted from egg yolk and can be used as a natural dietary supplement for the treatment of inflammation and damage to the intestines. In our study, IgY was embedded in a double emulsion (W/O/W; DE) to explore the therapeutic effect of the embedded IgY on Lipopolysaccharide (LPS)-induced jejunal injury in mice. The results showed that W/O/W-embedded IgY as a dietary supplement (IgY + DE) attenuated LPS-induced damage to mouse small intestinal structures and protected the integrity of the jejunal mucosal barrier.

A Pan-Cancer Analysis of the Oncogenic Role of CD276 in Human Tumors.

: B7 homolog 3 protein (B7-H3, also known as CD276) is a member of the B7 family that has been found to be associated with the growth and progression of a variety of tumors, but no pan-cancer evaluations of CD276 have been performed so far. In this study, we aimed to perform a pan-cancer analysis of the oncogenic role of CD276 in human tumors; : We used a series of databases to perform a pan-cancer analysis of CD276, including the expression level of CD276 in pan-cancer and its relationship to tumor progression, patient survival duration, the immune cell infiltration within the tumor, and the potential signaling pathways and molecular mechanisms associated with CD276; : We found that CD276 was a potential biomarker for the prognosis of most cancers. The high expression of CD276 was associated with tumor progression, leading to poor survival.

Atractylenolide Ⅲ partially alleviates tunicamycin-induced damage in porcine oocytes during in vitro maturation by reducing oxidative stress.

Assisted reproductive technology (ART) is widely used to address infertility and enhance reproductive outcomes in livestock. Among various ART techniques, in vitro maturation (IVM) is commonly used to obtain high-quality oocytes but is susceptible to oxidative stress. In traditional Chinese medicine, Rhizoma Atractylodis Macrocephalae (Bai Zhu) is used to enhance maternal and fetal health.

Systematic review and meta-analysis comparative analysis of the safety and efficacy of fenestrated pedicle screw with cement and conventional pedicle screw with cement in the treatment of osteoporotic vertebral fractures: A meta-analysis.

Purpose: Bone cement-reinforced fenestrated pedicle screws (FPSs) have been widely used in the internal fixation and repair of the spine with osteoporosis in recent years and show significant improvement in fixation strength and stability. However, compared with conventional reinforcement methods, the advantages of bone cement-reinforced FPSs remain undetermined. This article compares the effects of fenestrated and conventional pedicle screws (CPSs) combined with bone cement in the treatment of osteoporosis.

A novel method for intelligent operation and maintenance of transformers using deep visual large model DETR + X and digital twin.

To achieve real-time monitoring and intelligent maintenance of transformers, a framework based on deep vision and digital twin has been developed. An enhanced visual detection model, DETR + X, is proposed, implementing multidimensional sample data augmentation through Swin2SR and GAN networks. This model converts one-dimensional DGA data into three-dimensional feature images based on Gram angle fields, facilitating the transformation and fusion of heterogeneous modal information.

Cantilever-Enhanced Fiber-Optic Photoacoustic Spectrophone for Low-Pressure Gas Detection.

A cantilever-enhanced fiber-optic photoacoustic (PA) spectrophone is reported for trace gas detection at a low-pressure environment. A cantilever-based fiber-optic Fabry-Perot (F-P) interferometer (FPI) is utilized for simultaneous measurement of air pressure and PA pressure. Since the cantilever resonance frequency follows air pressure linearly, the fundamental frequency intensity modulation (1-IM) technique is applied to scan the frequency response of the solid PA signal from tube wall absorption for tracking the cantilever resonance frequency in real time.

Giant Photogalvanic Effect-Induced Terahertz Wave Emission in Wafer-Scale Type-II Dirac Semimetal PtTe.

Terahertz (THz) emission arising from the second-order nonlinear photocurrent effects in two-dimensional quantum materials has attracted significant attention due to its high efficiency and ease of polarization manipulation. However, in centrosymmetric quantum materials, the terahertz emission is typically suppressed, caused by the directional symmetry of the photocurrent generated under femtosecond laser excitation. In this work, we report that wafer-scale type-II Dirac semimetal PtTe with lattice centrosymmetry exhibits remarkably high THz emission efficiency (2 orders of magnitude greater than that of a ZnTe nonlinear crystal with equivalent thickness) and pronounced polarization sensitivity at room temperature.

Research hotspots and frontiers of vagus nerve stimulation in stroke: a bibliometric analysis.

Background: Vagus nerve stimulation (VNS) has emerged as a promising therapeutic approach for stroke treatment, drawing significant attention due to its potential benefits. However, despite this growing interest, a systematic bibliometric analysis of the research landscape is yet to be conducted.

Methods: We performed a comprehensive search of the Web of Science Core Collection (WoSCC) database for literature published between January 1, 2005, and August 31, 2024.

Automatic MRI-TRUS Fusion Technique for Transperineal Biopsy Guidance: From Preoperative Planning to Intraoperative Navigation.

Background: Targeted and systematic transperineal biopsy of lesions guided by magnetic resonance imaging (MRI) and transrectal ultrasonography (TRUS) fusion technique may optimize the biopsy procedure and enhance the detection of prostate cancer. We described the transperineal biopsy guided by an automatic MRI-TRUS fusion technique, and evaluated the accuracy and feasibility of this method in a prospective single-center study.

Methods: The proposed method focuses on automating the delineation of prostate contours in both the MRI and TRUS images, the registration and fusion of MRI and TRUS images, the generation and visualiztion of the systematic biopsy cores in their corresponding locations within the 2D and the 3D views, as well as the computation and visualiztion of needle trajectories from preoperative planning to intraoperative navigation.

Organic Iono-Optoelectronics: From Electrochromics to Artificial Retina.

ConspectusOrganic mixed ionic electronic conductors (OMIECs) represent an exciting and emerging class of materials that have recently revitalized the field of organic semiconductors. OMIECs are particularly attractive because they allow both ionic and electronic transport while retaining the inherent benefits of organic semiconducting materials such as mechanical conformability and biocompatibility. These combined properties make the OMIECs ideal for applications in bioelectronics, energy storage, neuromorphic computing, and electrochemical transistors for sensing.

High-throughput identification of Prunus mume freezing-tolerance genes based on yeast screening system and functional verification of PmRCI2-3 in Arabidopsis.

Prunus mume tops the ten most famous flowers of China with high ornamental value, and low temperature is the main factor limiting its northward migration. Cold resistance improvement is one of the important breeding directions of Rosaceae ornamental plants, especially the Prunus mume. Here, 29 genes from P.

Coherent-Precipitation-Stabilized Phase Formation in Over-Stoichiometric Rocksalt-Type Li Superionic Conductors.

Rationalizing synthetic pathways is crucial for material design and property optimization, especially for polymorphic and metastable phases. Over-stoichiometric rocksalt (ORX) compounds, characterized by their face-sharing configurations, are a promising group of materials with unique properties; however, their development is significantly hindered by challenges in synthesizability. Here, taking the recently identified Li superionic conductor, over-stoichiometric rocksalt Li-In-Sn-O (o-LISO) material as a prototypical ORX compound, the mechanisms of phase formation are systematically investigated.

Vagal response during radiofrequency catheter ablation initiated from right superior pulmonary vein: Incidence, risk factors, and clinical outcomes.

Background: The vagal response (VR) is unavoidable during pulmonary vein isolation (PVI) for atrial fibrillation (AF). In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of VR during PVI initiated from the right superior pulmonary vein (RSPV).

Methods: Patients with AF were consecutively enrolled.

Two-Dimensional MXenes: Innovative Materials for Efficient Thermal Management and Safety Solutions.

MXenes, a class of 2-dimensional transition metal carbides and nitrides, have garnered important attention due to their remarkable electrical and thermal conductivity, high photothermal conversion efficiency, and multifunctionality. This review explores the potential of MXene materials in various thermal applications, including thermal energy storage, heat dissipation in electronic devices, and the mitigation of electromagnetic interference in wearable technologies. Recent advancements in MXene composites, such as MXene/bacterial cellulose aerogel films and MXene/polymer composites, have demonstrated enhanced performance in phase change thermal storage and electromagnetic interference shielding, underscoring their versatility and effectiveness.

LHX3 promotes EMT in hepatoma cell through β-catenin/TCF4 pathway.

Hepatocellular carcinoma (HCC) is a highly malignant cancer and lacks effective therapeutic targets. The role of LIM/homeobox protein Lhx3 (LHX3) has been extensively studied in various tumor tissues, where it has been identified as a promoter of tumorigenesis and malignancy. However, the specific functional role and potential mechanism of LHX3 in human HCCs are not clearly clarified.

Colonization of stenotrophomonas and its associated microbiome between paired primary colorectal cancers and their lung metastatic tumors (experimental studies).

The role of gut microbiome in colorectal cancer (CRC) lung metastases is still unclear. Herein, we collected primary colorectal tumors, matched lung metastasis, and adjacent normal colon from seven patients for 16S rRNA sequencing to evaluate microbiome signature in distant site metastasis and analyze prognosis. Fecal samples from 19 non-metastases CRC patients and 11 CRC lung metastases patients were analyzed for validation.

Triboelectric Nanogenerator-Embedded Intelligent Self-Aligning Roller Bearing with the Capability of Self-Sensing, Monitoring, and Fault Diagnosis.

Monitoring the dynamic behaviors of self-aligning roller bearings (SABs) is vital to guarantee the stability of various mechanical systems. This study presents a novel self-powered, intelligent, and self-aligning roller bearing (I-SAB) with which to monitor rotational speeds and bias angles; it also has an application in fault diagnosis. The designed I-SAB is compactly embedded with a novel sweep-type triboelectric nanogenerator (TENG).

Tetramethyl Cucurbit[6]uril-Porphyrin Supramolecular Polymer Enhances Photosensitization.

Porphyrins serve as photosensitizers (PS) in the realm of cancer photodynamic therapy (PDT). Upon excitation by laser light, porphyrins are capable of converting molecular oxygen into highly cytotoxic singlet oxygen (O). However, the rigid π-conjugated structure of porphyrins frequently results in the formation of aggregates in aqueous solutions, which leads to the self-quenching of the excited state.