Epitaxial Ferroelectric Hexagonal Boron Nitride Grown on Graphene.

Ferroelectricity realized in van der Waals (vdW) materials with non-centrosymmetric stacking configurations holds promise for future 2D devices with nonvolatile and reconfigurable functionalities. However, the epitaxial growth of ferroelectric vdW materials often struggles to achieve an energetically unfavorable stacking configuration that enables electric polarization. This challenge is particularly evident when performing heteroepitaxy on another vdW substrate to create versatile and scalable ferroelectric building blocks designed for large-area, atomic-scale thicknesses.

Biportal Versus Uniportal Lumbar Decompression-Indications and Efficacy: A Review With Case Examples.

Minimally invasive lumbar decompression surgery offers many advantages including reduced patient morbidity and quicker return to normal life. Endoscopic lumbar spine surgery, sometimes termed "ultra" minimally invasive, further pushes the envelope on reducing operative time, blood loss, and recovery time. Endoscopy offers the additional advantage to the surgeon of placing the surgeon's eye not 50 cm away through the lens of loupes or a microscope, but right at the spine pathology in high definition.

Optimal Cutoff Values and Utility of High-Sensitivity Troponin T and NT-proBNP for the Risk Stratification of Patients with Acute Pulmonary Embolism.

Background: Guidelines recommend using high-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) to risk stratify hemodynamically stable patients with acute pulmonary embolism (PE). However, there are no evidence-based cutoff values defined for this clinical application.

Methods: We performed a single-center, retrospective cohort study of patients with imaging-confirmed PE and hsTnT and/or NT-proBNP (ElecsysTM, Roche) measured 12 h before or 24 h after PE Response Team (PERT) activation.

Quantifying the effects of the microphysical hygroscopic restructuring of soot on ensemble optical properties and satellite aerosol optical depth retrievals.

Black carbon, or soot, significantly contributes to atmospheric light absorption due to its low single scattering albedo (SSA). This study investigates the impact of soot's hygroscopic restructuring on satellite remote sensing, focusing on radiative forcing, top-of-atmosphere (TOA) reflectance, and aerosol optical depth (AOD) retrievals. We characterized soot aging using relative humidity (RH) growth factor functions and modeled fresh and aging soot aggregates using a cluster-cluster aggregation algorithm.

Changes and correlation of serum levels of interleukins 33, 15, 4, and interferon γ in children with bronchial asthma at different periods.

Aim: This work investigated the difference of serum cytokine levels in children with bronchial asthma (BA) in acute attack and clinical remission and the relationship between them.

Material And Methods: A hundred children with BA were included and enrolled into an acute attack group (AA group) and a clinical remission group (CR group) according to their medical history and clinical characteristics, with 50 children in each group. Then, another 50 healthy children in the same hospital for physical examination were randomly selected as controls.

Effect of Mg on Plasticity and Microstructure of Al-Mg-Ga-Sn-In Soluble Aluminum Alloy.

Soluble aluminum alloy materials used in underground operational tools are synthesized via a high-temperature smelting process. The microstructure and composition distribution of the alloy were analyzed using X-ray diffraction, metallographic microscopy, and scanning electron microscopy with energy-dispersive X-ray and electron backscatter diffraction techniques. The mechanical properties were evaluated using a universal testing machine and hardness tester, while solubility assessments were conducted in a constant-temperature water bath.

Atractylodin modulates ASAH3L to improve galactose metabolism and inflammation to alleviate acute lung injury.

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) has good anti-inflammatory activity and protects the integrity of the epithelial cell barrier. However, the efficacy of ATL in the treatment of ALI and its mechanism is unclear.

Network Pharmacology and in vitro Experimental Verification on Intervention of Oridonin on Non-Small Cell Lung Cancer.

Objective: To explore the key target molecules and potential mechanisms of oridonin against non-small cell lung cancer (NSCLC).

Methods: The target molecules of oridonin were retrieved from SEA, STITCH, SuperPred and TargetPred databases; target genes associated with the treatment of NSCLC were retrieved from GeneCards, DisGeNET and TTD databases. Then, the overlapping target molecules between the drug and the disease were identified.

Safety of treating acute pulmonary embolism at home: an individual patient data meta-analysis.

Background And Aims: Home treatment is considered safe in acute pulmonary embolism (PE) patients selected by a validated triage tool (e.g. simplified PE severity index score or Hestia rule), but there is uncertainty regarding the applicability in underrepresented subgroups.

Clinical Characteristics and Analysis of Risk Factors for Concomitant Liver Damage of Infectious Mononucleosis in Children: A Single-Center Retrospective Study.

Objective: To analyze the manifestations of infectious mononucleosis and its impact on liver function in children.

Methods: This retrospective study analyzed clinical data from 695 children with infectious mononucleosis (IM) who were hospitalized at the Department of Pediatrics, Chengdu First People's Hospital between January 1, 2017, and December 31, 2022. They were analyzed into two groups according to whether their ALT was greater than 40 U/L.

Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization.

Background: Helicobacter pylori (H. pylori), according to a number of recent observational studies, is connected to atherosclerosis (AS). However, the link between H.

Rhizome Polysaccharide Alleviates Immunosuppression and Intestinal Mucosal Injury in Mice Treated with Cyclophosphamide.

Plant-derived polysaccharides, such as rhizome polysaccharide (ALP), are good immune regulators. However, the immune regulatory mechanism of the ALP is unknown. This study aimed to evaluate the effects of ALP on the intestinal mucosal barrier and intestinal mucosal immunity of immunosuppressed mice.

Disparities in Primary Spinal Osseous Malignant Bone Tumor Survival by Medicaid Status: A National Population-Based Risk Analysis.

Background: The impact of Medicaid status on survival outcomes of patients with spinal primary malignant bone tumors (sPMBT) has not been investigated.

Methods: Using the SEER-Medicaid database, adults diagnosed between 2006 and 2013 with sPMBT including chordoma, osteosarcoma, chondrosarcoma, Ewing sarcoma, or malignant giant cell tumor (GCT) were studied. Five-year survival analysis was performed using the Kaplan-Meier method.

Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats.

Ethnopharmacological Relevance: Spleen Yang Deficiency Syndrome (SYDS), which is a syndrome commonly treated with Traditional Chinese Medicine (TCM), manifests as overall metabolic dysfunction caused mainly by digestive system disorders. Atractylodes lancea (Thunb.) DC.

Photoinduced Nonvolatile Resistive Switching Behavior in Oxygen-Doped MoS for a Neuromorphic Vision System.

Controlling resistance by external fields provides fascinating opportunities for the development of novel devices and circuits, such as temperature-field-induced superconductors, magnetic-field-triggered giant magnetoresistance devices, and electric-field-operated flash memories. In this work, we demonstrate a light-triggered nonvolatile resistive switching behavior in oxygen-doped MoS. The two-terminal devices exhibit stable light-modulated resistive switching characteristics and optically tunable synaptic properties with an on/off ratio of up to 10.

Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.

Liver fibrosis is one of the leading causes of hepatic sclerosis and hepatocellular carcinoma worldwide. However, the complex pathophysiological mechanisms of liver fibrosis are unknown, and no specific drugs are available to treat liver fibrosis. Atractylenolide III (ATL III) is a natural compound isolated from the plant (Thunb.

A comprehensive medical Spanish curriculum model: the Vida Medical Spanish Curriculum.

Introduction: Racial and language disparities in the United States healthcare system have long undermined the quality of care provided to minority patients. With the projected growth of the Hispanic population, there is an urgent need for medical schools to integrate high-quality medical Spanish and cultural competency content. We propose a comprehensive medical Spanish curriculum aligned with the preclinical curriculum as a solution to these issues.

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate (MVA) pathway.

Ignition control and waste heat assessment of spontaneous combustion gangue hill by gravity heat pipe group: a case study in Shanxi Province, China.

Spontaneous combustion gangue hill has attracted great attention due to serious environmental pollution and terrible geological disasters. However, the rich thermal resources inside are often ignored. In order to control the spontaneous combustion of gangue hill and utilize the internal waste heat resources, this project studied the combined treatment effect of 821 gravity heat pipes, laid 47 sets of temperature monitoring devices, evaluated the storage of waste heat resources, and proposed different waste heat utilization methods.

Embedded information of aerosol type, hygroscopicity and scattering enhancement factor revealed by the relationship between PM and aerosol optical depth.

Satellite aerosol optical depth (AOD) provides an alternative way to depict the spatial distribution of near-surface PM. In this study, a mathematical formulation of how PM is related to AOD is presented. When simplified to a linear equation, a functional dependence of the slope on the aerosol type, scattering enhancement factor f(RH), and boundary layer height is revealed, while the influence of the vertical aerosol profile is embedded in the intercept.