Publications by authors named "Ke Chang"

Background: Guidelines recommend using high-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) to risk stratify hemodynamically stable patients with acute pulmonary embolism (PE). However, there are no evidence-based cutoff values defined for this clinical application.

Methods: We performed a single-center, retrospective cohort study of patients with imaging-confirmed PE and hsTnT and/or NT-proBNP (ElecsysTM, Roche) measured 12 h before or 24 h after PE Response Team (PERT) activation.

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Black carbon, or soot, significantly contributes to atmospheric light absorption due to its low single scattering albedo (SSA). This study investigates the impact of soot's hygroscopic restructuring on satellite remote sensing, focusing on radiative forcing, top-of-atmosphere (TOA) reflectance, and aerosol optical depth (AOD) retrievals. We characterized soot aging using relative humidity (RH) growth factor functions and modeled fresh and aging soot aggregates using a cluster-cluster aggregation algorithm.

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Soluble aluminum alloy materials used in underground operational tools are synthesized via a high-temperature smelting process. The microstructure and composition distribution of the alloy were analyzed using X-ray diffraction, metallographic microscopy, and scanning electron microscopy with energy-dispersive X-ray and electron backscatter diffraction techniques. The mechanical properties were evaluated using a universal testing machine and hardness tester, while solubility assessments were conducted in a constant-temperature water bath.

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Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) has good anti-inflammatory activity and protects the integrity of the epithelial cell barrier. However, the efficacy of ATL in the treatment of ALI and its mechanism is unclear.

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Objective: To explore the key target molecules and potential mechanisms of oridonin against non-small cell lung cancer (NSCLC).

Methods: The target molecules of oridonin were retrieved from SEA, STITCH, SuperPred and TargetPred databases; target genes associated with the treatment of NSCLC were retrieved from GeneCards, DisGeNET and TTD databases. Then, the overlapping target molecules between the drug and the disease were identified.

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Article Synopsis
  • - The study focuses on a new device for intraventricular drug delivery that allows for wireless control of medication output, reducing toxicity while targeting the central nervous system directly.
  • - Six sheep were implanted with a pump and catheter to administer varying doses of methotrexate (MTX) over 12 weeks, with drug levels monitored regularly.
  • - Results showed no toxicity in sheep and confirmed that the device effectively maintained methotrexate levels in the cerebrospinal fluid through adjustable, metronomic delivery.
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Background And Aims: Home treatment is considered safe in acute pulmonary embolism (PE) patients selected by a validated triage tool (e.g. simplified PE severity index score or Hestia rule), but there is uncertainty regarding the applicability in underrepresented subgroups.

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Objective: To analyze the manifestations of infectious mononucleosis and its impact on liver function in children.

Methods: This retrospective study analyzed clinical data from 695 children with infectious mononucleosis (IM) who were hospitalized at the Department of Pediatrics, Chengdu First People's Hospital between January 1, 2017, and December 31, 2022. They were analyzed into two groups according to whether their ALT was greater than 40 U/L.

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During the unprecedented COVID-19 city lockdown, a unique opportunity arose to dissect the intricate dynamics of urban air quality, focusing on ultrafine particles (UFPs) and volatile organic compounds (VOCs). This study delves into the nuanced interplay between traffic patterns and UFP emissions in a subtropical urban setting during the spring-summer transition of 2021. Leveraging meticulous roadside measurements near a traffic nexus, our investigation unravels the intricate relationship between particle number size distribution (PNSD), VOCs mixing ratios, and detailed vehicle activity metrics.

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Article Synopsis
  • This study investigates the prevalence and genetic diversity of rotavirus group A (RVA) in the Pearl River Delta region of Guangdong, China, focusing on individuals aged 28 days to 85 years.
  • Out of 706 stool samples from patients with acute gastroenteritis, 14.59% tested positive for RVA, with co-infections noted in nearly 40% of cases, particularly affecting young children.
  • The predominant RVA genotype identified was G9P[8], and findings highlight the need for enhanced surveillance of RVA genetic changes to inform future vaccine development.
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Background: Helicobacter pylori (H. pylori), according to a number of recent observational studies, is connected to atherosclerosis (AS). However, the link between H.

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Plant-derived polysaccharides, such as rhizome polysaccharide (ALP), are good immune regulators. However, the immune regulatory mechanism of the ALP is unknown. This study aimed to evaluate the effects of ALP on the intestinal mucosal barrier and intestinal mucosal immunity of immunosuppressed mice.

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Background: The impact of Medicaid status on survival outcomes of patients with spinal primary malignant bone tumors (sPMBT) has not been investigated.

Methods: Using the SEER-Medicaid database, adults diagnosed between 2006 and 2013 with sPMBT including chordoma, osteosarcoma, chondrosarcoma, Ewing sarcoma, or malignant giant cell tumor (GCT) were studied. Five-year survival analysis was performed using the Kaplan-Meier method.

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Ethnopharmacological Relevance: Spleen Yang Deficiency Syndrome (SYDS), which is a syndrome commonly treated with Traditional Chinese Medicine (TCM), manifests as overall metabolic dysfunction caused mainly by digestive system disorders. Atractylodes lancea (Thunb.) DC.

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Controlling resistance by external fields provides fascinating opportunities for the development of novel devices and circuits, such as temperature-field-induced superconductors, magnetic-field-triggered giant magnetoresistance devices, and electric-field-operated flash memories. In this work, we demonstrate a light-triggered nonvolatile resistive switching behavior in oxygen-doped MoS. The two-terminal devices exhibit stable light-modulated resistive switching characteristics and optically tunable synaptic properties with an on/off ratio of up to 10.

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Article Synopsis
  • The use of lumbar fusion surgery has significantly risen over the past 20 years, but recent studies show no solid advantage for combining fusion with decompression surgery in patients with lumbar stenosis and degenerative spondylolisthesis.
  • A study assessed national trends from 2016 to 2019, analyzing over 121,000 adult patients undergoing these procedures, using data from the National Inpatient Sample.
  • Results indicated a decline in surgeries performed with decompression alone (from 32.6% to 9.6%) and a rise in surgeries that included fusion (from 67.4%), highlighting a shift towards more combined surgical approaches.
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Liver fibrosis is one of the leading causes of hepatic sclerosis and hepatocellular carcinoma worldwide. However, the complex pathophysiological mechanisms of liver fibrosis are unknown, and no specific drugs are available to treat liver fibrosis. Atractylenolide III (ATL III) is a natural compound isolated from the plant (Thunb.

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Introduction: Racial and language disparities in the United States healthcare system have long undermined the quality of care provided to minority patients. With the projected growth of the Hispanic population, there is an urgent need for medical schools to integrate high-quality medical Spanish and cultural competency content. We propose a comprehensive medical Spanish curriculum aligned with the preclinical curriculum as a solution to these issues.

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The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate (MVA) pathway.

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Spontaneous combustion gangue hill has attracted great attention due to serious environmental pollution and terrible geological disasters. However, the rich thermal resources inside are often ignored. In order to control the spontaneous combustion of gangue hill and utilize the internal waste heat resources, this project studied the combined treatment effect of 821 gravity heat pipes, laid 47 sets of temperature monitoring devices, evaluated the storage of waste heat resources, and proposed different waste heat utilization methods.

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Satellite aerosol optical depth (AOD) provides an alternative way to depict the spatial distribution of near-surface PM. In this study, a mathematical formulation of how PM is related to AOD is presented. When simplified to a linear equation, a functional dependence of the slope on the aerosol type, scattering enhancement factor f(RH), and boundary layer height is revealed, while the influence of the vertical aerosol profile is embedded in the intercept.

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: Liver fibrosis is a pathological outcome of a variety of liver diseases, and it can also progress into liver cirrhosis and liver cancer. Specific liver antifibrotic drugs have not been clinically approved yet. Studies have demonstrated the protective effects of Ganfule capsule (GFL) on the liver and its therapeutic potential in hepatic cancer.

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Electrocardiogram (ECG) and carotid ultrasound (CUS) are important tools for the diagnosis and prediction of cardiovascular disease (CVD). This study aimed to investigate the associations between ECG and CUS parameters and explore the feasibility of assessing carotid health with ECG. This cross-sectional cohort study enrolled 319 healthy Chinese subjects.

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