Publications by authors named "Kazuyoshi Hatsuda"
Background: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with a poor prognosis and unknown aetiology. We have recently clarified the prognostic value of the serum platelet-derived growth factor (PDGF) level in patients with IPF. Interleukin (IL)-11 is a member of the IL-6 family, and and studies have suggested that it has profibrotic effects in pulmonary fibrosis.
View Article and Find Full Text PDFBackground: Idiopathic pulmonary fibrosis is a fibrotic disease of unknown aetiology and has a poor prognosis. Some patients experience episodes of rapid deterioration known as acute exacerbations (AEs), which are often fatal. This study aimed to clarify whether serum cytokine levels can predict the outcome of idiopathic pulmonary fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- Acute exacerbation (AE) in idiopathic interstitial pneumonias (IIPs) is linked to worse outcomes, and the study builds on previous findings that corticosteroids combined with thrombomodulin may improve survival for these patients.
- The research involved 28 patients from the SETUP trial, measuring serum cytokine levels and analyzing CT patterns to assess their impact on 90-day survival after AE-IIPs treatments.
- Key findings include that higher serum levels of certain cytokines, especially RANTES, and specific CT patterns significantly predict survival chances, with an increase in IL-10 on day 8 indicating potential mortality risk.
Background: Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease characterized by the abnormal accumulation of surfactant-like material within the alveolar spaces and distal bronchioles. If high-resolution computed tomography (HRCT) indicates the presence of PAP, a definitive diagnosis of PAP is established when consistent pathological findings are obtained. Herein, we retrospectively studied the yield and safety of bronchofiberscopy in the diagnosis of PAP.
View Article and Find Full Text PDFBackground: Anti-granulocyte-macrophage colony-stimulating factor autoantibody (GMAb) has been recognized as a diagnostic biomarker for autoimmune pulmonary alveolar proteinosis (aPAP). The aims of this study were to know the incidence of increased level of serum GMAb in granulomatous lung diseases (sarcoidosis and hypersensitivity pneumonitis [HP]) and to clarify the role of GMAb. Consecutive individuals diagnosed with sarcoidosis (n = 92) and HP (n = 45) at National Hospital Organization Kinki-Chuo Chest Medical Center were retrospectively analyzed.
View Article and Find Full Text PDFIntroduction: Semi-solid nutrition with high viscosity has the advantage of reducing gastroesophageal reflux and diarrhea and shortens the duration of administration compared with liquid nutrition. This is the first report describing the administration of semi-solid nutrition with high viscosity via a nasogastric tube, which achieved a remarkable improvement in the patient's nutritional state.
Case Presentation: A 67-year-old man (mongoloid race, Japanese) with tuberculosis, a pressure ulcer and malnutrition was admitted to our hospital.