Publications by authors named "Kazuya Kurokawa"
Ophthalmol Ther
June 2019
Article Synopsis
- This study investigates how the pH of brimonidine ophthalmic solutions affects its distribution in the posterior ocular tissues of pigmented rabbits after topical administration.
- The research involved analyzing tissue samples at various time points post-administration of two different pH solutions (6.4 and 7.3) to compare brimonidine concentrations.
- Results show that while both pH levels lead to significant drug bioavailability, the increase from pH 6.4 to 7.3 boosts brimonidine levels in posterior ocular tissues, suggesting similar absorption in the aqueous humor.
Article Synopsis
- The study investigates how the concentration of brimonidine, an eye drop medication, in the vitreous (the gel-like substance in the eye) relates to its free concentration in the retina/choroid (the target area for the drug).
- Researchers conducted experiments on pigmented rabbits to measure brimonidine levels after administering the drops and studied its binding to melanin in the eye tissues.
- Results showed that the concentration of brimonidine in the vitreous is closely linked to the free concentration in the retina/choroid, suggesting that vitreous concentration can serve as an indicator of drug levels in this target area.
