Publications by authors named "Kazutaka Yamaji"
Article Synopsis
- Genome-wide analysis reveals that alterations in IKZF1, CRLF2, and JAK2 are linked to poor prognosis in pediatric BCP-ALL, but their significance was not previously established for Japanese patients.
- A study of 194 BCP-ALL patients found IKZF1 deletions and CRLF2-high expression in a small percentage, with JAK2 mutations being rare.
- The presence of IKZF1 deletions and high CRLF2 expression significantly lowered the 4-year event-free survival rates in high-risk patients but not in the standard-risk group, indicating their role as prognostic factors.
Background: Pirarubicin (tetrahydropyranyl-adriamycin: THP) is a derivative of doxorubicin with reportedly less cardiotoxicity in adults. However no studies of cardiotoxicity in children treated with THP have been reported. This study was performed to assess the THP-induced cardiotoxicity for children with acute lymphoblastic leukemia (ALL).
View Article and Find Full Text PDFBackground: The majority of minimal residual disease (MRD)-positive patients with acute lymphoblastic leukemia (ALL) have poor outcomes. The ALL2000 study was performed to evaluate the efficacy of augmented chemotherapy based on MRD-restratification in childhood ALL.
Procedure: Between 2000 and 2004, 305 eligible patients with precursor B or T-cell ALL were enrolled in the ALL2000 study.