Publications by authors named "Kazutaka Shimizu"
Article Synopsis
- The study aimed to understand how the cerebellum and basal ganglia contribute to temporal integration by analyzing 39 patients with different types of spinocerebellar degeneration (SCD) and 13 control subjects.
- Patients tapped in sync with tones, and researchers measured their tapping performance through various metrics like inter-tap interval and synchronizing tapping error.
- Results indicated that while SCD patients generally showed more variability in tapping (particularly in MSA and SCA6), SCA31 patients surprisingly performed normally, highlighting the complex interaction between these brain regions in timing tasks.
Background: The cerebellum is known to play a crucial role in sensori-motor adaptation, which includes the prism adaptation. TRH has been widely used as a treatment for cerebellar ataxia in Japan, however effects of TRH on cerebellar adaptation process have not been studied. Here, we studied effects of TRH treatment on the prism adaptation task.
View Article and Find Full Text PDFObjective: Lipopolysaccharide (LPS) triggers sepsis and systemic inflammatory response syndrome, which results in multiple organ failure. Our recent reports demonstrated that hepatocyte growth factor (HGF) attenuated angiotensin II-induced oxidative stress via epithelial growth factor receptor (EGFR) degradation in vascular smooth muscle cells. Here, we examined whether HGF can protect against systemic inflammatory response syndrome induced by LPS and investigated the mechanism.
View Article and Find Full Text PDF