Publications by authors named "Kazushige Ihara"

Article Synopsis
  • The study explores how apathetic and depressive symptoms in older adults affect their functional capacity, which relates to daily living and social engagement activities.
  • Involving 212 participants, the study utilized established scales to measure apathy and depression, assessing their impacts on different aspects of functional capability.
  • Findings indicate that certain dimensions of apathy, particularly emotional and initiation symptoms, negatively influence life management and information practices, while depressive symptoms primarily affect social engagement.
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Age-related hearing loss (ARHL) and impaired gait both independently heighten the risk of accidental falls among older adults. However, the combined impact of these factors remains unclear. We analyzed the data of 786 community-dwelling Japanese older adults.

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Introduction: To detect early cognitive impairment in community-dwelling older adults, this study explored the viability of artificial intelligence (AI)-assisted linear acceleration and angular velocity analysis during walking.

Methods: This cross-sectional study included 879 participants without dementia (female, 60.6%; mean age, 73.

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Aim: The Japanese Society for Respiratory Care and Rehabilitation, Japanese Association on Sarcopenia and Frailty, Japanese Society of Respiratory Physical Therapy, and Japanese Association of Rehabilitation Nutrition proposed the definition and diagnosis of respiratory sarcopenia using low respiratory muscle strength and appendicular skeletal muscle mass (ASM; ASM/height) instead of respiratory muscle mass; however, these parameters have not been validated. This study aimed to confirm the validity of the respiratory sarcopenia definition proposed by these four professional organizations.

Methods: Participants of our cohort study in 2015 of 468 community-dwelling older people who were evaluated for sarcopenia and underwent spirometry were included in this analysis.

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The predictive abilities of computer-based screening devices for early cognitive decline (CD) in older adults have rarely been longitudinally examined. Therefore, this study examined the ability of CogEvo, a short-duration, computer-based cognitive screening device requiring little professional involvement, to predict CD among community-dwelling older adults. We determined whether 119 individuals aged ≥ 65 years living in Japanese rural communities who scored ≥ 24 on the Mini-Mental State Examination (MMSE) at baseline developed CD by annually administering the MMSE to them.

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Article Synopsis
  • Social isolation in older adults is linked to higher mortality rates, but some prefer solitude; understanding how to mitigate health risks in isolation is essential.
  • This study analyzed the impact of combining social isolation and regular exercise on mortality among older adults in Tokyo, with a focus on those exercising at least twice a week.
  • Results showed that isolated individuals who exercised had a 19.3% mortality rate, while those who were not isolated and exercised had the lowest rate at 6.1%, highlighting the potential protective effects of exercise against isolation-related risks.
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Background: Maintaining higher-level functional capacity is important for independent living in older age. The aging trajectory of the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) has three patterns; however, the subscale patterns are unclear.

Aims: This study aimed to clarify the aging trajectory patterns of the TMIG-IC subscales among community-dwelling older Japanese.

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Introduction: Social isolation has been recognized as a contributing factor to negative health outcomes. Although living alone is associated with health-related outcomes, existing findings are inconsistent. It is not the act of living alone that may predict poor health, but rather social isolation that can lead to increased mortality risk.

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The association between the gut microbiota and muscle strength has garnered attention in the context of mitigating muscle decline. However, many study subjects have been individuals with existing illnesses or the elderly only. This study aims to elucidate the association between the gut microbiota and muscle strength indicators using grip strength/BMI in a large-scale study of community residents.

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Social isolation among older adults affects their physical and mental health. Ego-resilience is associated with flexible adaptation to various environments and acceptable behaviors. However, its association with social isolation among older people is unclear.

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Objectives: To investigate the trajectories of social networks and interactions among older Japanese individuals during the COVID-19 pandemic.

Study Design: We used data from a cohort of community-dwelling older individuals from the Otassha study's 2019-2022 survey. Participants comprised 606 older individuals who participated in the 2019 survey and were followed up at least once.

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Exposure to environmental heavy metals is associated with telomere length (TL) alteration. Available information regarding the effect of prenatal exposure to environmental pollutants on newborn TL is controversial. The aim of this study is to systematically review and conduct a meta-analysis of the existing epidemiological studies on the associations between prenatal metal exposure and newborn TL.

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Aim: To develop a rapid and easy screening tool to detect sarcopenia.

Methods: In total, 683 community-dwelling older adults who participated in our cohort study, the "Otassha Study," in 2019, completely responded to a questionnaire, and were diagnosed with sarcopenia were included. Participants responded to a nine-item questionnaire, including candidate items for a new sarcopenia screening tool named rapid sarcopenia screening, based on items of the Strength, Assistance with walking, Rising from a chair, Climbing stairs, and Falls (SARC-F) questionnaire.

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Telomeres, repeated TTAGGG sequences at chromosomal ends, shorten with age and indicate cellular lifespan. Zinc can protect against telomere damage through its anti-oxidative effect. Meanwhile, telomere shortening was correlated with metabolic diseases of hypertension and type 2 diabetes.

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Mood and anxiety disorders are frequent in the elderly and increase the risk of frailty. This study aimed to identify novel biomarkers of major depressive disorder (MDD) and anxiety in the elderly. We examined 639 participants in the community-dwelling Otassha Study (518 individuals considered healthy control, 77 with depression, anxiety, etc.

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Article Synopsis
  • Depression is a major global health issue, and its link to gut microbiota has been under-researched, especially in the Japanese population.
  • The study analyzed health data from Iwaki between 2017 and 2019, focusing on 37 gut microbiota genera and their relationship with depression levels measured by a specific depression scale.
  • Nine genera showed significant statistical relevance, with some linked to butyrate production, suggesting that gut bacteria may play a role in influencing depression through this process.
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  • The study aimed to develop and validate a comprehensive model for assessing masticatory function, taking into account factors like muscle mass and chewing ability, particularly in older adults.
  • Involving 753 participants with an average age of 73, it categorized them into groups with multiple masticatory dysfunction (MMD) and severe MMD (S-MMD) based on specific criteria.
  • Findings revealed that S-MMD was associated with lower serum albumin levels and increased self-reported chewing difficulties, validating the model as an effective tool for identifying those at risk of masticatory issues.
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Introduction: This longitudinal study aimed to identify aging trajectory patterns of social interaction by sex and determine the association between these patterns and all-cause mortality.

Methods: Participants were 4,065 community-dwelling older adults (1849 men) in Japan, aged 65-89 years, who responded twice or more to a mail survey conducted between 2012 and 2020. Social interaction was examined through the frequency of face-to-face and non-face-to-face contact with non-resident family and friends.

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Aim: To assess the validity of self-reported articulatory oral motor skill against objectively measured repetitive articulatory rate (oral diadochokinesis [oral-DDK]) as a gold standard index for articulatory oral motor skill in community-dwelling older Japanese adults.

Methods: This cross-sectional study included 607 Japanese adults (mean age = 73.9 years).

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Aim: To evaluate the association between vitamin D status and periodontal inflammation as determined by the periodontal inflamed surface area (PISA) in community-dwelling older adults.

Materials And Methods: This cross-sectional study included 467 Japanese adults (mean age = 73.1 years) who underwent full-mouth periodontal examinations and measurements of serum levels of 25-hydroxyvitamin D (25(OH)D).

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Background: The frequency of combined declines in domains of multi-faceted frailty and their impact on adverse health outcomes have not been adequately investigated. We aimed to examine the association between combined subscale declines in higher-level functional capacity and 8-year all-cause mortality among community-dwelling older Japanese individuals and the impact of multi-faceted frailty on mortality.

Materials And Methods: We administered a questionnaire to 7015 community-dwelling older adults aged 65-85 years.

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Background: Ferritin is associated with an increased prevalence of diabetes mellitus. Moreover, the ferritin levels differ across the body compositions. Although there were studies reporting the association of ferritin and diabetes, the alteration in ferritin-diabetes association by body composition differences is rarely explained.

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