Publications by authors named "Kazushi Shimizu"
Article Synopsis
- Researchers designed a chimeric DNA-RNA hammerhead ribozyme targeting SARS-CoV based on a sequence from mouse hepatitis virus (MHV) to develop a specific treatment for SARS.
- The ribozyme successfully cleaved MHV and SARS-CoV RNA in laboratory tests and inhibited MHV multiplication by approximately 60% in DBT cells, showcasing its effectiveness.
- The study suggests that this synthetic ribozyme could be a potential treatment option for managing SARS infections.
